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Substance Name: Trimeprazine
RN: 84-96-8
UNII: 76H78MJJ52
InChIKey: ZZHLYYDVIOPZBE-UHFFFAOYSA-N

Note

  • A phenothiazine derivative that is used as an antipruritic.

Molecular Formula

  • C18-H22-N2-S

Molecular Weight

  • 298.4518
 

Classification Codes

  • Antipruritics
  • Dermatologic Agents
  • Drug / Therapeutic Agent
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Names and Synonyms

Results Name

  • Trimeprazine

Name of Substance

  • Alimemazine [INN:BAN]
  • Methylpromazine
  • Trimeprazine

MeSH Heading

  • Trimeprazine

Synonyms

  • (+-)-Alimemazine
  • (+-)-Trimeprazine
  • 10-(2-Methyl-3-dimethylaminopropyl)-phenothiazine
  • 10-(3-(Dimethylamino)-2-methylpropyl)phenothiazine
  • 10H-Phenothiazine-10-propanamine, N,N,beta-trimethyl-
  • Alimemazina
  • Alimemazina [INN-Spanish]
  • Alimemazine
  • Alimemazinum
  • Alimemazinum [INN-Latin]
  • Alimezine
  • Bayer 1219
  • dl-Trimeprazine
  • EINECS 201-577-3
  • HSDB 3197
  • Methylpromazine
  • N,N,beta-Trimethyl-10H-phenothiazine-10-propanamine
  • Phenothiazine, 10-(3-(dimethylamino)-2-methylpropyl)-
  • Repetin
  • RP 6549
  • Teralen
  • Trimeprazine
  • UNII-76H78MJJ52

Systematic Names

  • 10H-Phenothiazine-10-propanamine, N,N,beta-trimethyl-
  • Alimemazine
  • Phenothiazine, 10-(3-(dimethylamino)-2-methylpropyl)-

Registry Numbers

CAS Registry Number

  • 84-96-8

FDA UNII

  • 76H78MJJ52

System Generated Number

  • 0000084968

Structure Descriptors

InChI

1S/C18H22N2S/c1-14(12-19(2)3)13-20-15-8-4-6-10-17(15)21-18-11-7-5-9-16(18)20/h4-11,14H,12-13H2,1-3H3

InChIKey

ZZHLYYDVIOPZBE-UHFFFAOYSA-N

Smiles

CC(CN1c2ccccc2Sc3c1cccc3)CN(C)C

Toxicity

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
mouse LD50 intravenous 33mg/kg (33mg/kg)   Psychopharmacology Service Center, Bulletin. Vol. 2, Pg. 17, 1963.
mouse LD50 oral 300mg/kg (300mg/kg) BEHAVIORAL: ANTIPSYCHOTIC Developments in Neuroscience Vol. 7, Pg. 45, 1980.
mouse LD50 subcutaneous 300mg/kg (300mg/kg)   Gekkan Yakuji. Pharmaceuticals Monthly. Vol. 9, Pg. 759, 1967.
rat LD50 intravenous 35mg/kg (35mg/kg)   Acta Neurologia et Psychiatrica Belgica. Vol. 61, Pg. 669, 1961.
rat LD50 oral 210mg/kg (210mg/kg)   Acta Neurologia et Psychiatrica Belgica. Vol. 61, Pg. 669, 1961.

Physical Properties

Physical Property Value Units Temp (deg C) Source
Melting Point 68 deg C   EXP
pKa Dissociation Constant 9.05 (none)   EXP
log P (octanol-water) 4.71 (none)   EXP
Water Solubility 0.942 mg/L 25 EST
Vapor Pressure 5.88E-07 mm Hg 25 EST
Henry's Law Constant 6.60E-10 atm-m3/mole 25 EST
Atmospheric OH Rate Constant 2.73E-10 cm3/molecule-sec 25 EST

Physical property data is provided to ChemIDplus by SRC, Inc.