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Substance Name: Perazine
RN: 84-97-9
UNII: 8915147A2B
InChIKey: WEYVCQFUGFRXOM-UHFFFAOYSA-N

Note

  • A phenothiazine antipsychotic with actions and uses similar to those of CHLORPROMAZINE. Extrapyramidal symptoms may be more common than other side effects.

Molecular Formula

  • C20-H25-N3-S

Molecular Weight

  • 339.5045
 

Classification Codes

  • Antipsychotic Agents
  • Central Nervous System Agents
  • Central Nervous System Depressants
  • Dopamine Agents
  • Dopamine Antagonists
  • Drug / Therapeutic Agent
  • Human Data
  • Neurotransmitter Agents
  • Psychotropic Drugs
  • Tranquilizing Agents
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Names and Synonyms

Name of Substance

  • Perazine

MeSH Heading

  • Perazine

Synonyms

  • EINECS 201-578-9
  • N-(3-(4-Methyl-1-piperazinyl)propyl)phenothiazine
  • N-Methyl-piperazinyl-N'-propyl-phenothiazin
  • N-Methyl-piperazinyl-N'-propyl-phenothiazin [German]
  • P 725
  • Perazine
  • Pernazine
  • Psytomin
  • Taxilan
  • UNII-8915147A2B

Systematic Names

  • 10-(3-(4-Methyl-1-piperazinyl)propyl)-10H-phenothiazine
  • 10H-Phenothiazine, 10-(3-(4-methyl-1-piperazinyl)propyl)-
  • Phenothiazine, 10-(3-(4-methyl-1-piperazinyl)propyl)-

Registry Numbers

CAS Registry Number

  • 84-97-9

FDA UNII

  • 8915147A2B

Related Registry Numbers

  • 14516-56-4 (maleate (1:2))
  • 5317-37-3 (di-hydrochloride)
  • 6002-77-3 (maleate)

System Generated Number

  • 0000084979

Molecular Formulas

Molecular Formula

  • C20-H25-N3-S

Molecular Formula Fragment

  • C20-H25-N3-S

Structure Descriptors

InChI

1S/C20H25N3S/c1-21-13-15-22(16-14-21)11-6-12-23-17-7-2-4-9-19(17)24-20-10-5-3-8-18(20)23/h2-5,7-10H,6,11-16H2,1H3

InChIKey

WEYVCQFUGFRXOM-UHFFFAOYSA-N

Smiles

CN1CCN(CC1)CCCN2c3ccccc3Sc4c2cccc4

Toxicity

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
human TDLo unreported 270mg/kg/28D (270mg/kg) BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)

BEHAVIORAL: ATAXIA
Arzneimittel-Forschung. Drug Research. Vol. 32, Pg. 911, 1982.
mouse LD50 intraperitoneal 185mg/kg (185mg/kg)   Arzneimittel-Forschung. Drug Research. Vol. 8, Pg. 199, 1958.
mouse LD50 intravenous 75mg/kg (75mg/kg)   Arzneimittel-Forschung. Drug Research. Vol. 8, Pg. 199, 1958.
mouse LD50 oral 640mg/kg (640mg/kg)   Arzneimittel-Forschung. Drug Research. Vol. 8, Pg. 199, 1958.
mouse LD50 subcutaneous 560mg/kg (560mg/kg)   Arzneimittel-Forschung. Drug Research. Vol. 8, Pg. 199, 1958.
rabbit LD50 intravenous 25mg/kg (25mg/kg)   Arzneimittel-Forschung. Drug Research. Vol. 8, Pg. 199, 1958.
rat LD50 intraperitoneal 300mg/kg (300mg/kg)   Arzneimittel-Forschung. Drug Research. Vol. 8, Pg. 199, 1958.
rat LD50 intravenous 80mg/kg (80mg/kg)   Arzneimittel-Forschung. Drug Research. Vol. 8, Pg. 199, 1958.
rat LD50 oral 500mg/kg (500mg/kg) BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD Archives Internationales de Pharmacodynamie et de Therapie. Vol. 115, Pg. 1, 1958.

Physical Properties

Physical Property Value Units Temp (deg C) Source
Melting Point 51-53 deg C   EXP
pKa Dissociation Constant 8.05 (none)   EXP
log P (octanol-water) 4 (none)   EXP
Water Solubility 2.170 mg/L 25 EST
Vapor Pressure 1.01E-08 mm Hg 25 EST
Henry's Law Constant 1.44E-13 atm-m3/mole 25 EST
Atmospheric OH Rate Constant 3.79E-10 cm3/molecule-sec 25 EST

Physical property data is provided to ChemIDplus by SRC, Inc.