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Substance Name: Lamotrigine [USAN:USP:INN:BAN]
RN: 84057-84-1
UNII: U3H27498KS
InChIKey: PYZRQGJRPPTADH-UHFFFAOYSA-N

Note

  • Blocks voltage-gated sodium and calcium channels and inhibits release of excitatory neurotransmitters such as glutamate.

Molecular Formula

  • C9-H7-Cl2-N5

Molecular Weight

  • 256.0953
 

Classification Codes

  • Anticonvulsant
  • Anticonvulsants
  • Calcium Channel Blockers
  • Cardiovascular Agents
  • Central Nervous System Agents
  • Drug / Therapeutic Agent
  • Excitatory Amino Acid Agents
  • Excitatory Amino Acid Antagonists
  • Human Data
  • Membrane Transport Modulators
  • Neurotransmitter Agents
  • Sodium Channel Blockers
  • Voltage-Gated Sodium Channel Blockers

Names and Synonyms

Name of Substance

  • Lamotrigine
  • Lamotrigine [USAN:USP:INN:BAN]

Synonyms

  • 3,5-Diamino-6-(2,3-dichlorophenyl)-1,2,4-triazine
  • 3,5-Diamino-6-(2,3-dichlorophenyl)-as-triazine
  • 6-(2,3-Dichlorophenyl)-1,2,4-triazine-3,5-diamine
  • BW 430C
  • BW430C
  • EINECS 281-901-8
  • HSDB 7526
  • Lamictal
  • Lamictal CD
  • Lamictal Odt
  • Lamictal Xr
  • Lamitor
  • Lamotrigina
  • Lamotrigina [Spanish]
  • Lamotrigine
  • Lamotriginum
  • Lamotriginum [Latin]
  • UNII-U3H27498KS

Systematic Names

  • 1,2,4-Triazine-3,5-diamine, 6-(2,3-dichlorophenyl)-
  • Lamotrigine

Registry Numbers

CAS Registry Number

  • 84057-84-1

FDA UNII

  • U3H27498KS

System Generated Number

  • 0084057841

Structure Descriptors

InChI

1S/C9H7Cl2N5/c10-5-3-1-2-4(6(5)11)7-8(12)14-9(13)16-15-7/h1-3H,(H4,12,13,14,16)

InChIKey

PYZRQGJRPPTADH-UHFFFAOYSA-N

Smiles

Nc1nnc(c(N)n1)c2cccc(Cl)c2Cl

Toxicity

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
man TDLo oral 19mg/kg (19mg/kg) CARDIAC: EKG CHANGES NOT DIAGNOSTIC OF ABOVE

SENSE ORGANS AND SPECIAL SENSES: OTHER: EYE

BEHAVIORAL: MUSCLE CONTRACTION OR SPASTICITY)
Lancet. Vol. 342, Pg. 1552, 1993.
man TDLo oral 45mg/kg/25D-I (45mg/kg) SKIN AND APPENDAGES (SKIN): "DERMATITIS, OTHER: AFTER SYSTEMIC EXPOSURE" Journal of Clinical Psychiatry. Vol. 59, Pg. 87, 1998.
mouse LD50 oral 245mg/kg (245mg/kg)   Epilepsia Vol. 25, Pg. 655, 1984.
rat LD50 oral 205mg/kg (205mg/kg)   Epilepsia Vol. 25, Pg. 655, 1984.
women TDLo oral 2mg/kg/30H-I (2mg/kg) GASTROINTESTINAL: NAUSEA OR VOMITING

KIDNEY, URETER, AND BLADDER: "CHANGES IN TUBULES (INCLUDING ACUTE RENAL FAILURE, ACUTE TUBULAR NECROSIS)"
Pediatrics. Vol. 98, Pg. 294, 1996.