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Substance Name: Bucolome [INN:JAN]
RN: 841-73-6
UNII: 9T08RAL174
InChIKey: DVEQCIBLXRSYPH-UHFFFAOYSA-N

Note

  • Proposed anti-inflammatory agent with possible analgesic properties.

Classification Codes

  • Drug / Therapeutic Agent
  • Reproductive Effect

Molecular Formula

  • C14-H22-N2-O3

Molecular Weight

  • 266.3388
 
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Names and Synonyms

Name of Substance

  • Bucolome
  • Bucolome [INN:JAN]

Synonyms

  • 2,4,6(1H,3H,5H)-Pyrimidinetrione, 5-butyl-1-cyclohexyl-
  • 5-24-09-00132 (Beilstein Handbook Reference)
  • 5-Butyl-1-cyclohexyl-2,4,6(1H,3H,5H)-pyrimidinetrione
  • 5-Butyl-1-cyclohexylbarbituric acid
  • 5-n-Butyl-1-cyclohexyl-2,4,6-trioxoperhydropyrimidine
  • BCP
  • BRN 0755320
  • Bucolom
  • Bucolome
  • Bucolomo
  • Bucolomo [INN-Spanish]
  • Bucolomum
  • Bucolomum [INN-Latin]
  • EINECS 212-666-1
  • Paramidin
  • Paramidine
  • UNII-9T08RAL174

Systematic Names

  • 2,4,6(1H,3H,5H)-Pyrimidinetrione, 5-butyl-1-cyclohexyl-
  • 5-Butyl-1-cyclohexylbarbituric acid
  • Barbituric acid, 5-butyl-1-cyclohexyl-
  • Bucolome

Registry Numbers

CAS Registry Number

  • 841-73-6

FDA UNII

  • 9T08RAL174

System Generated Number

  • 0000841736

Structure Descriptors

InChI

1S/C14H22N2O3/c1-2-3-9-11-12(17)15-14(19)16(13(11)18)10-7-5-4-6-8-10/h10-11H,2-9H2,1H3,(H,15,17,19)

InChIKey

DVEQCIBLXRSYPH-UHFFFAOYSA-N

Smiles

CCCCC1C(=O)NC(=O)N(C2CCCCC2)C1=O

Toxicity

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
mouse LD50 intraperitoneal 550mg/kg (550mg/kg) LUNGS, THORAX, OR RESPIRATION: DYSPNEA

BEHAVIORAL: ATAXIA

BEHAVIORAL: ALTERED SLEEP TIME (INCLUDING CHANGE IN RIGHTING REFLEX)
Nippon Yakurigaku Zasshi. Japanese Journal of Pharmacology. Vol. 63, Pg. 43, 1967.
mouse LD50 intravenous 371mg/kg (371mg/kg)   Gekkan Yakuji. Pharmaceuticals Monthly. Vol. 9, Pg. 342, 1967.
mouse LD50 oral 1550mg/kg (1550mg/kg) BEHAVIORAL: ALTERED SLEEP TIME (INCLUDING CHANGE IN RIGHTING REFLEX)

LUNGS, THORAX, OR RESPIRATION: DYSPNEA

BEHAVIORAL: ATAXIA
Nippon Yakurigaku Zasshi. Japanese Journal of Pharmacology. Vol. 63, Pg. 43, 1967.
mouse LD50 subcutaneous 446mg/kg (446mg/kg)   Gekkan Yakuji. Pharmaceuticals Monthly. Vol. 9, Pg. 342, 1967.
rat LD50 intraperitoneal 455mg/kg (455mg/kg) BEHAVIORAL: ALTERED SLEEP TIME (INCLUDING CHANGE IN RIGHTING REFLEX)

LUNGS, THORAX, OR RESPIRATION: DYSPNEA

BEHAVIORAL: ATAXIA
Nippon Yakurigaku Zasshi. Japanese Journal of Pharmacology. Vol. 63, Pg. 43, 1967.
rat LD50 oral 1115mg/kg (1115mg/kg) BEHAVIORAL: ALTERED SLEEP TIME (INCLUDING CHANGE IN RIGHTING REFLEX)

LUNGS, THORAX, OR RESPIRATION: DYSPNEA

BEHAVIORAL: ATAXIA
Nippon Yakurigaku Zasshi. Japanese Journal of Pharmacology. Vol. 63, Pg. 43, 1967.

Physical Properties

Physical Property Value Units Temp (deg C) Source
Melting Point 84 deg C   EXP
log P (octanol-water) 3.120 (none)   EST
Atmospheric OH Rate Constant 2.97E-11 cm3/molecule-sec 25 EST

Physical property data is provided to ChemIDplus by SRC, Inc.