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Substance Name: Bedaquiline [USAN:INN]
RN: 843663-66-1
UNII: 78846I289Y
InChIKey: QUIJNHUBAXPXFS-XLJNKUFUSA-N

Notes

  • A diarylquinoline Antitubercular Agent.
  • A diarylquinoline Antitubercular Agent.

    Daily Med: SIRTURO is a diarylquinoline antimycobacterial drug indicated as part of combination therapy in adults (>= 18 years) with pulmonary multi-drug resistant tuberculosis (MDR-TB). Reserve SIRTURO for use when an effective treatment regimen cannot otherwise be provided. SIRTURO is not indicated for the treatment of latent, extra-pulmonary or drug-sensitive tuberculosis.

Molecular Formula

  • C32-H31-Br-N2-O2

Molecular Weight

  • 555.5129
 

Classification Codes

  • Anti-Bacterial Agents
  • Anti-Infective Agents
  • Antitubercular Agents
  • Treatment of Tuberculosis

Names and Synonyms

Results Name

  • Bedaquiline [USAN:INN]

Name of Substance

  • Bedaquiline
  • Bedaquiline [USAN:INN]

Synonyms

  • 1-(6-Bromo-2-methoxy-quinolin-3-yl)-4-dimethylamino-2-naphthalen-1-yl-1-phenyl-butan-2-ol
  • AIDS 222089
  • AIDS-222089
  • Bedaquiline
  • HSDB 8217
  • R 207910
  • R207910
  • Sirturo
  • TMC 207
  • TMC-207
  • TMC207
  • UNII-78846I289Y

Systematic Name

  • 3-Quinolineethanol, 6-bromo-alpha-(2-(dimethylamino)ethyl)-2-methoxy-alpha-1-naphthalenyl-beta-phenyl-, (alphaS,betaR)-

Registry Numbers

CAS Registry Number

  • 843663-66-1

FDA UNII

  • 78846I289Y

System Generated Number

  • 0843663661

Structure Descriptors

InChI

1S/C32H31BrN2O2/c1-35(2)19-18-32(36,28-15-9-13-22-10-7-8-14-26(22)28)30(23-11-5-4-6-12-23)27-21-24-20-25(33)16-17-29(24)34-31(27)37-3/h4-17,20-21,30,36H,18-19H2,1-3H3/t30-,32-/m1/s1

InChIKey

QUIJNHUBAXPXFS-XLJNKUFUSA-N

Smiles

CN(C)CC[C@@](c1cccc2c1cccc2)([C@H](c3ccccc3)c4cc5cc(ccc5nc4OC)Br)O