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Substance Name: Mifepristone [USAN:INN:BAN]
RN: 84371-65-3
UNII: 320T6RNW1F
InChIKey: VKHAHZOOUSRJNA-GCNJZUOMSA-N

Note

  • A progestational and glucocorticoid hormone antagonist. Its inhibition of progesterone induces bleeding during the luteal phase and in early pregnancy by releasing endogenous prostaglandins from the endometrium or decidua. As a glucocorticoid receptor antagonist, the drug has been used to treat hypercortisolism in patients with nonpituitary CUSHING SYNDROME.

Molecular Formula

  • C29-H35-N-O2

Molecular Weight

  • 429.6005
 

Classification Codes

  • Abortifacient Agents
  • Abortifacient Agents, Steroidal
  • Contraception
  • Contraceptive Agents
  • Contraceptive Agents, Female
  • Contraceptive Agents, Hormonal
  • Contraceptives, Oral
  • Contraceptives, Oral, Synthetic
  • Contraceptives, Postcoital
  • Contraceptives, Postcoital, Synthetic
  • Hormone
  • Hormone Antagonists
  • Hormones, Hormone Substitutes, and Hormone Antagonists
  • Human Data
  • Induction of Abortion
  • Luteolytic Agents
  • Menstruation-Inducing Agents
  • Reproductive Control Agents
  • Reproductive Effect
  • Treatment of Gynecological Disorders (Progesterone Antagonist)

Names and Synonyms

Name of Substance

  • Mifepristone
  • Mifepristone [USAN:INN:BAN]

MeSH Heading

  • Mifepristone

Synonyms

  • (11beta,17beta)-11-(4-(Dimethylamino)phenyl)-17-hydroxy-17-(1-propynyl)-estra-4,9-dien-3-one
  • 11beta-(4-(Dimethylamino)phenyl)-17-hydroxy-21-methyl-19-nor-17alpha-pregna-4,9-dien-20-m-3-on
  • 11beta-(4-(Dimethylamino)phenyl)-17beta-hydroxy-17-(1-propynyl)estra-4,9-dien-3-on
  • 11beta-(4-(N,N-Dimethylamino)phenyl)-17alpha-(prop-1-ynyl)-delta4,9-estradiene-17beta-ol-3-one
  • 11beta-(p-(Dimethylamino)phenyl)-17beta-hydroxy-17-(1-propynyl)estra-4,9-dien-3-one
  • 17-beta-Hydroxy-11-beta-(4-dimethylaminophenyl-1)-17-alpha-(prop-1-ynyl)oestra-4,9-dien-3-one
  • BRN 5779404
  • CCRIS 9332
  • Corlux
  • HSDB 6841
  • Korlym
  • Mifegyne
  • Mifeprex
  • Mifepristona
  • Mifepristona [Spanish]
  • Mifepristone
  • Mifepristonum
  • Mifepristonum [Latin]
  • NSC 759862
  • R 38486
  • RU 38486
  • RU 486
  • RU 486-6
  • UNII-320T6RNW1F

Systematic Names

  • 11beta-(p-(Dimethylamino)phenyl)-17beta-hydroxy-17-(1-propynyl)estra-4,9-dien-3-one
  • Estra-4,9-dien-3-one, 11-(4-(dimethylamino)phenyl)-17-hydroxy-17-(1-propynyl)-, (11-beta,17-beta)-

Registry Numbers

CAS Registry Number

  • 84371-65-3

FDA UNII

  • 320T6RNW1F

Other Registry Numbers

  • 122742-25-0
  • 83203-42-3

System Generated Number

  • 0084371653

Structure Descriptors

InChI

InChI=1S/C29H35NO2/c1-5-15-29(32)16-14-26-24-12-8-20-17-22(31)11-13-23(20)27(24)25(18-28(26,29)2)19-6-9-21(10-7-19)30(3)4/h6-7,9-10,17,24-26,32H,8,11-14,16,18H2,1-4H3/t24-,25+,26-,28-,29-/m0/s1

InChIKey

VKHAHZOOUSRJNA-GCNJZUOMSA-N

Smiles

CC#C[C@]1(O)CC[C@H]2[C@@H]3CCC4=CC(=O)CCC4=C3[C@H](C[C@]12C)c5ccc(cc5)N(C)C