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Substance Name: Irsogladine maleate [JAN]
RN: 84504-69-8
UNII: 66GVU60EPQ
InChIKey: PJLVTVAIERNDEQ-BTJKTKAUSA-N

Classification Codes

  • Drug / Therapeutic Agent
  • Reproductive Effect

Molecular Formula

  • C9-H7-Cl2-N5.C4-H4-O4

Molecular Weight

  • 372.167
 
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Names and Synonyms

Name of Substance

  • Irsogladine maleate
  • Irsogladine maleate [JAN]

Synonyms

  • 1,3,5-Triazine-2,4-diamine, 6-(2,5-dichlorophenyl)-, (Z)-2-butenedioate (1:1)
  • 2,4-Diamino-6-(2,5-dichlorophenyl)-s-triazine maleate
  • CCRIS 8107
  • Gaslon
  • Irsogladine maleate
  • MN-1695
  • UNII-66GVU60EPQ

Systematic Name

  • s-Triazine, 2,4-diamino-6-(2,5-dichlorophenyl)-, maleate

Registry Numbers

CAS Registry Number

  • 84504-69-8

FDA UNII

  • 66GVU60EPQ

Related Registry Number

  • 57381-26-7 (Parent)

System Generated Number

  • 0084504698

Molecular Formulas

Molecular Formula

  • C9-H7-Cl2-N5.C4-H4-O4

Molecular Formula Fragments

  • C4-H4-O4
  • C9-H7-Cl2-N5
  • COMPONENT

Structure Descriptors

InChI

1S/C9H7Cl2N5.C4H4O4/c10-4-1-2-6(11)5(3-4)7-14-8(12)16-9(13)15-7;5-3(6)1-2-4(7)8/h1-3H,(H4,12,13,14,15,16);1-2H,(H,5,6)(H,7,8)/b;2-1-

InChIKey

PJLVTVAIERNDEQ-BTJKTKAUSA-N

Smiles

c1(cc(c2nc(nc(N)n2)N)c(Cl)cc1)Cl.OC(\C=C/C(O)=O)=O

Toxicity

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
dog LD50 intraperitoneal 100mg/kg (100mg/kg) GASTROINTESTINAL: NAUSEA OR VOMITING

BEHAVIORAL: ATAXIA

SENSE ORGANS AND SPECIAL SENSES: LACRIMATION: EYE
Oyo Yakuri. Pharmacometrics. Vol. 32, Pg. 861, 1986.
mouse LD50 intraperitoneal 775mg/kg (775mg/kg)   Arzneimittel-Forschung. Drug Research. Vol. 34, Pg. 474, 1984.
mouse LD50 intravenous > 250mg/kg (250mg/kg)   Iyakuhin Kenkyu. Study of Medical Supplies. Vol. 20, Pg. 228, 1989.
mouse LD50 oral 5697mg/kg (5697mg/kg)   Arzneimittel-Forschung. Drug Research. Vol. 34, Pg. 474, 1984.
mouse LD50 subcutaneous 2841mg/kg (2841mg/kg)   Arzneimittel-Forschung. Drug Research. Vol. 34, Pg. 474, 1984.
rabbit LD50 oral 1gm/kg (1000mg/kg) GASTROINTESTINAL: CHANGES IN STRUCTURE OR FUNCTION OF SALIVARY GLANDS

SENSE ORGANS AND SPECIAL SENSES: LACRIMATION: EYE

BEHAVIORAL: ALTERED SLEEP TIME (INCLUDING CHANGE IN RIGHTING REFLEX)
Oyo Yakuri. Pharmacometrics. Vol. 32, Pg. 861, 1986.
rat LD50 intraperitoneal 495mg/kg (495mg/kg)   United States Patent Document. Vol. #4657907,
rat LD50 oral 2898mg/kg (2898mg/kg)   European Patent Application. Vol. #114907,
rat LD50 subcutaneous 1524mg/kg (1524mg/kg)   Arzneimittel-Forschung. Drug Research. Vol. 34, Pg. 474, 1984.