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Substance Name: Bedaquiline fumarate [USAN]
RN: 845533-86-0
UNII: P04QX2C1A5
InChIKey: ZLVSPMRFRHMMOY-WWCCMVHESA-N

Note

  • A diarylquinoline Antitubercular Agent.

    Daily Med: SIRTURO is a diarylquinoline antimycobacterial drug indicated as part of combination therapy in adults (>= 18 years) with pulmonary multi-drug resistant tuberculosis (MDR-TB). Reserve SIRTURO for use when an effective treatment regimen cannot otherwise be provided. SIRTURO is not indicated for the treatment of latent, extra-pulmonary or drug-sensitive tuberculosis.

Molecular Weight

  • 671.5845
 

Classification Codes

  • Anti-Bacterial Agents
  • Anti-Infective Agents
  • Antitubercular Agents
  • Treatment of Tuberculosis
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Names and Synonyms

Name of Substance

  • Bedaquiline fumarate [USAN]

Synonyms

  • Bedaquiline fumarate
  • R403323
  • Sirturo
  • UNII-P04QX2C1A5

Systematic Name

  • 3-Quinolineethanol, 6-bromo-alpha-(2-(dimethylamino)ethyl)-2-methoxy-alpha-1-naphthalenyl- -phenyl-, (S,R)-, (2E)-2-butenedioate (1:1) (salt)

Registry Numbers

CAS Registry Number

  • 845533-86-0

FDA UNII

  • P04QX2C1A5

System Generated Number

  • 0845533860

Structure Descriptors

InChI

1S/C32H31BrN2O2.C4H4O4/c1-35(2)19-18-32(36,28-15-9-13-22-10-7-8-14-26(22)28)30(23-11-5-4-6-12-23)27-21-24-20-25(33)16-17-29(24)34-31(27)37-3;5-3(6)1-2-4(7)8/h4-17,20-21,30,36H,18-19H2,1-3H3;1-2H,(H,5,6)(H,7,8)/b;2-1+/t30-,32-;/m1./s1

InChIKey

ZLVSPMRFRHMMOY-WWCCMVHESA-N

Smiles

COc1nc2ccc(Br)cc2cc1[C@@H](c3ccccc3)[C@@](O)(CCN(C)C)c4cccc5ccccc45.OC(=O)\C=C\C(=O)O