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Substance Name: Lorazepam [USAN:USP:INN:BAN:JAN]
RN: 846-49-1
UNII: O26FZP769L
InChIKey: DIWRORZWFLOCLC-UHFFFAOYSA-N
Note
- A benzodiazepine used as an anti-anxiety agent with few side effects. It also has hypnotic, anticonvulsant, and considerable sedative properties and has been proposed as a preanesthetic agent.
Molecular Formula
- C15-H10-Cl2-N2-O2
Molecular Weight
- 321.162
- All
- Classifications
- Links to Resources
- Names & Synonyms
- Registry Numbers
- Structure Descriptors
- Toxicity
- Physical Properties
Classification Codes
Classification Codes
- Anti-Anxiety Agents
- Anticonvulsants
- Antiemetics
- Autonomic Agents
- Central Nervous System Agents
- Central Nervous System Depressants
- Drug / Therapeutic Agent
- GABA Agents
- GABA Modulators
- Gastrointestinal Agents
- Human Data
- Hypnotics and Sedatives
- Neurotransmitter Agents
- Peripheral Nervous System Agents
- Psychotropic Drugs
- Reproductive Effect
- Tranquilizer (Minor)
- Tranquilizing Agents
Superlist Classification Code
- DEA Schedule IV
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Links to Resources
NLM Resources (File Locators)
Regulatory Agencies (Superlist Locators)
Other Resources (Internet Locators)
Search for this InChIKey on the Web
Names and Synonyms
Name of Substance
- Lorazepam
- Lorazepam [USAN:USP:INN:BAN:JAN]
MeSH Heading
- Lorazepam
Synonyms
- (+-)-7-Chloro-5-(o-chlorophenyl)-1,3-dihydro-3-hydroxy-2H-1,4-benzodiazepin-2-one
- 2H-1,4-Benzodiazepin-2-one, 7-chloro-5-(2-chlorophenyl)-1,3-dihydro-3-hydroxy-, (+-)-
- 5-25-02-00248 (Beilstein Handbook Reference)
- 7-Chloro-5-(2-chlorophenyl)-1,3-dihydro-3-hydroxy-2H-1,4-benzodiazepin-2-one
- 7-Chloro-5-(2-chlorophenyl)-3-hydroxy-1H-1,4-benzodiazepin-2(3H)-one
- 7-Chloro-5-(o-chlorophenyl)-1,3-dihydro-3-hydroxy-2H-1,4-benzodiazepin-2-one
- Almazine
- Anxiedin
- Anxira
- Anzepam
- Aplacasse
- Aplacassee
- Apo-Lorazepam
- Aripax
- Ativan
- Azurogen
- Bonatranquan
- Bonton
- BRN 0759084
- Delormetazepam
- Demethyllormetazepam
- Donix
- Duralozam
- Efasedan
- EINECS 212-687-6
- Emotion
- Emotival
- Equitam
- Idalprem
- Kalmalin
- Larpose
- Laubeel
- Lomesta
- Lopam
- Lorabenz
- Lorafen
- Loram
- Lorans
- Lorapam
- Lorat
- Lorax
- Loraz
- Lorazene
- Lorazep
- Lorazepam
- Lorazepam Fabra
- Lorazepam Genericon
- Lorazepam intensol
- Lorazepam Lannacher
- Lorazepam Medical
- Lorazepam preservative free
- Lorazepam-Efeka
- Lorazepamum
- Lorazepamum [INN-Latin]
- Lorazepan Chobet
- Lorazepan Richet
- Lorazin
- Lorazon
- Lorenin
- Loridem
- Lorivan
- Lorsedal
- Lorzem
- Lozepam
- Max Pax
- Merlit
- Nervistop L
- Nervistopl
- NIC
- Norlormetazepam
- Novhepar
- Novolorazem
- NSC 289758
- Nu Loraz
- o-Chlorooxazepam
- o-Chloroxazepam
- Orfidal
- Punktyl
- Quait
- Renaquil
- Rocosgen
- Sedatival
- Sedizepan
- Sidenar
- Silence
- Sinestron
- Stapam
- Tavor
- Temesta
- Titus
- Tolid
- Tranqipam
- Trapax
- UNII-O26FZP769L
- Upan
- Vigiten
- WY 4036
- Wy-4036
- Wypax
Systematic Names
- 2H-1,4-Benzodiazepin-2-one, 7-chloro-5-(2-chlorophenyl)-1,3-dihydro-3-hydroxy-
- Lorazepam
Superlist Names
- DEA No. 2885
- Lorazepam
Registry Numbers
CAS Registry Number
- 846-49-1
FDA UNII
- O26FZP769L
System Generated Number
- 0000846491
Structure Descriptors
InChI
InChI=1S/C15H10Cl2N2O2/c16-8-5-6-12-10(7-8)13(19-15(21)14(20)18-12)9-3-1-2-4-11(9)17/h1-7,15,21H,(H,18,20)InChIKey
DIWRORZWFLOCLC-UHFFFAOYSA-NSmiles
OC1N=C(c2ccccc2Cl)Toxicity
Organism | Test Type | Route | Reported Dose (Normalized Dose) | Effect | Source |
---|---|---|---|---|---|
child | TDLo | oral | 71ug/kg (0.071mg/kg) | BEHAVIORAL: ATAXIA BEHAVIORAL: GENERAL ANESTHETIC BEHAVIORAL: "HALLUCINATIONS, DISTORTED PERCEPTIONS" | Toxicology Letters. Vol. 2, Pg. 109, 1978. |
child | TDLo | oral | 1208ug/kg (1.208mg/kg) | BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY) VASCULAR: BP LOWERING NOT CHARACTERIZED IN AUTONOMIC SECTION LUNGS, THORAX, OR RESPIRATION: PLEURAL THICKENING | Pediatric Emergency Care. Vol. 11, Pg. 32, 1995. |
dog | LD50 | intramuscular | > 25mg/kg (25mg/kg) | BEHAVIORAL: ATAXIA GASTROINTESTINAL: NAUSEA OR VOMITING BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY) | Arzneimittel-Forschung. Drug Research. Vol. 21, Pg. 1065, 1971. |
dog | LD50 | oral | > 2gm/kg (2000mg/kg) | GASTROINTESTINAL: NAUSEA OR VOMITING BEHAVIORAL: ATAXIA | Arzneimittel-Forschung. Drug Research. Vol. 21, Pg. 1065, 1971. |
human | TDLo | oral | 21ug/kg (0.021mg/kg) | BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY) BEHAVIORAL: ALTERATION OF CLASSICAL CONDITIONING | Clinical Pharmacology and Therapeutics Vol. 39, Pg. 526, 1986. |
human | TDLo | oral | 28ug/kg (0.028mg/kg) | BEHAVIORAL: CHANGES IN PSYCHOPHYSIOLOGICAL TESTS | Journal of Clinical Psychiatry. Vol. 46, Pg. 137, 1985. |
mouse | LD50 | intramuscular | 70mg/kg (70mg/kg) | BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY) | Arzneimittel-Forschung. Drug Research. Vol. 21, Pg. 1065, 1971. |
mouse | LD50 | intraperitoneal | 1810mg/kg (1810mg/kg) | Jitchuken Zenrinsho Kenkyuho. Central Institute for Experimental Animals, Research Reports. Vol. 1, Pg. 5, 1974. | |
mouse | LD50 | oral | 1850mg/kg (1850mg/kg) | Iyakuhin Kenkyu. Study of Medical Supplies. Vol. 8, Pg. 680, 1977. | |
mouse | LD50 | subcutaneous | > 10gm/kg (10000mg/kg) | Jitchuken Zenrinsho Kenkyuho. Central Institute for Experimental Animals, Research Reports. Vol. 1(1), Pg. 5, 1974. | |
rat | LD50 | intramuscular | 59mg/kg (59mg/kg) | BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY) | Arzneimittel-Forschung. Drug Research. Vol. 21, Pg. 1065, 1971. |
rat | LD50 | intraperitoneal | 870mg/kg (870mg/kg) | Pharmacology: International Journal of Experimental and Clinical Pharmacology. Vol. 10, Pg. 345, 1973. | |
rat | LD50 | oral | 4500mg/kg (4500mg/kg) | Iyakuhin Kenkyu. Study of Medical Supplies. Vol. 8, Pg. 680, 1977. | |
rat | LD50 | subcutaneous | > 10gm/kg (10000mg/kg) | Yakkyoku. Pharmacy. Vol. 28, Pg. 1475, 1977. | |
women | TDLo | oral | 380ug/kg/19D- (0.38mg/kg) | BLOOD: CHANGES IN BONE MARROW NOT INCLUDED ABOVE BLOOD: APLASTIC ANEMIA | British Medical Journal. Vol. 296, Pg. 1332, 1988. |
Physical Properties
Physical Property | Value | Units | Temp (deg C) | Source |
---|---|---|---|---|
Melting Point | 167 | deg C | EXP | |
pKa Dissociation Constant | 13 | (none) | EXP | |
log P (octanol-water) | 2.39 | (none) | EXP | |
Water Solubility | 80 | mg/L | EXP | |
Vapor Pressure | 7.95E-13 | mm Hg | 25 | EST |
Henry's Law Constant | 4.10E-10 | atm-m3/mole | 25 | EST |
Atmospheric OH Rate Constant | 1.12E-11 | cm3/molecule-sec | 25 | EST |
Physical property data is provided to ChemIDplus by SRC, Inc.