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Substance Name: Temazepam [USAN:USP:INN:BAN]
RN: 846-50-4
UNII: CHB1QD2QSS
InChIKey: SEQDDYPDSLOBDC-UHFFFAOYSA-N
Note
- A benzodiazepine that acts as a GAMMA-AMINOBUTYRIC ACID modulator and anti-anxiety agent.
Molecular Formula
- C16-H13-Cl-N2-O2
Molecular Weight
- 300.7437
- All
- Classifications
- Links to Resources
- Names & Synonyms
- Registry Numbers
- Structure Descriptors
- Toxicity
- Physical Properties
Classification Codes
Classification Codes
- Anti-Anxiety Agents
- Central Nervous System Agents
- Central Nervous System Depressants
- Drug / Therapeutic Agent
- GABA Agents
- GABA Modulators
- Human Data
- Hypnotics and Sedatives
- Neurotransmitter Agents
- Psychotropic Drugs
- Tranquilizer (Minor)
- Tranquilizing Agents
- Tumor Data
Superlist Classification Codes
- DEA Schedule IV
- Overall Carcinogenic Evaluation: Group 3
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Links to Resources
NLM Resources (File Locators)
Regulatory Agencies (Superlist Locators)
Other Resources (Internet Locators)
Search for this InChIKey on the Web
Names and Synonyms
Name of Substance
- Temazepam
- Temazepam [USAN:USP:INN:BAN]
MeSH Heading
- Temazepam
Synonyms
- 1,3-Dihydro-7-chloro-3-hydroxy-1-methyl-5-phenyl-2H-1,4-benzodiazepin-2-one
- 3-Hydroxydiazepam
- 5-25-02-00242 (Beilstein Handbook Reference)
- 7-Chloro-1,3-dihydro-3-hydroxy-1-methyl-5-phenyl-2H-1,4-benzodiazepin-2-one
- BRN 0759300
- CCRIS 1954
- Cerepax
- Crisonar
- Dasuen
- EINECS 212-688-1
- ER 115
- Euhypnos
- Euipnos
- Hydroxydiazepam
- K-3917
- K3917
- Lenal
- Levanxene
- Levanxol
- Mabertin
- Methyloxazepam
- N-Methyloxazepam
- Neodorm SP
- Nocturne
- Nomapam
- Norkotral Tema
- Normison
- Normitab
- Nortem
- NSC 246303
- Oxydiazepam
- Planum
- Pronervon T
- Remestan
- Restoril
- Ro 5-5345
- Signopam
- Strazepam
- Temador
- Temaz
- temazep von ct
- Temazepam
- Temazepamum
- Temazepamum [INN-Latin]
- Temtabs
- Tenox
- UNII-CHB1QD2QSS
- Uvamin Retard
- WY 3917
- Wy-3917
Systematic Names
- 2H-1,4-Benzodiazepin-2-one, 7-chloro-1,3-dihydro-3-hydroxy-1-methyl-5-phenyl-
- Temazepam
Superlist Names
- DEA No. 2925
- Temazepam
Registry Numbers
CAS Registry Number
- 846-50-4
FDA UNII
- CHB1QD2QSS
System Generated Number
- 0000846504
Structure Descriptors
InChI
InChI=1S/C16H13ClN2O2/c1-19-13-8-7-11(17)9-12(13)14(18-15(20)16(19)21)10-5-3-2-4-6-10/h2-9,15,20H,1H3InChIKey
SEQDDYPDSLOBDC-UHFFFAOYSA-NSmiles
CN1C(=O)Toxicity
Organism | Test Type | Route | Reported Dose (Normalized Dose) | Effect | Source |
---|---|---|---|---|---|
dog | LD50 | oral | 3620mg/kg (3620mg/kg) | Drugs. International Journal of Current Therapeutics and Applied Pharmacology Reviews. Vol. 21, Pg. 321, 1981. | |
human | TDLo | oral | 600ug/kg (0.6mg/kg) | BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY) | Human Psychopharmacology. Vol. 10, Pg. 449, 1995. |
human | TDLo | oral | 15430ug/kg/12 (15.43mg/kg) | GASTROINTESTINAL: CHANGES IN STRUCTURE OR FUNCTION OF SALIVARY GLANDS BEHAVIORAL: MUSCLE WEAKNESS | Arzneimittel-Forschung. Drug Research. Vol. 22, Pg. 93, 1972. |
man | TDLo | oral | 429ug/kg (0.429mg/kg) | BEHAVIORAL: EXCITEMENT BEHAVIORAL: REGIDITY | Journal of Clinical Psychiatry. Vol. 46, Pg. 280, 1985. |
mouse | LD50 | intraperitoneal | 85mg/kg (85mg/kg) | Archives Internationales de Pharmacodynamie et de Therapie. Vol. 185, Pg. 135, 1970. | |
mouse | LD50 | oral | 370mg/kg (370mg/kg) | BEHAVIORAL: ANTICONVULSANT | European Journal of Pharmacology. Vol. 4, Pg. 467, 1968. |
rat | LD50 | intraperitoneal | 600mg/kg (600mg/kg) | Drugs. International Journal of Current Therapeutics and Applied Pharmacology Reviews. Vol. 21, Pg. 321, 1981. | |
rat | LD50 | oral | 2gm/kg (2000mg/kg) | Drugs. International Journal of Current Therapeutics and Applied Pharmacology Reviews. Vol. 21, Pg. 321, 1981. | |
women | TDLo | oral | 600ug/kg (0.6mg/kg) | BEHAVIORAL: EXCITEMENT | Journal of Clinical Psychiatry. Vol. 46, Pg. 280, 1985. |
Physical Properties
Physical Property | Value | Units | Temp (deg C) | Source |
---|---|---|---|---|
Melting Point | 119-121 | deg C | EXP | |
log P (octanol-water) | 2.19 | (none) | EXP | |
Water Solubility | 164 | mg/L | 25 | EST |
Vapor Pressure | 2.14E-11 | mm Hg | 25 | EST |
Henry's Law Constant | 1.13E-08 | atm-m3/mole | 25 | EST |
Atmospheric OH Rate Constant | 1.44E-11 | cm3/molecule-sec | 25 | EST |
Physical property data is provided to ChemIDplus by SRC, Inc.