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Substance Name: Temazepam [USAN:USP:INN:BAN]
RN: 846-50-4
UNII: CHB1QD2QSS
InChIKey: SEQDDYPDSLOBDC-UHFFFAOYSA-N

Note

  • A benzodiazepine that acts as a GAMMA-AMINOBUTYRIC ACID modulator and anti-anxiety agent.

Molecular Formula

  • C16-H13-Cl-N2-O2

Molecular Weight

  • 300.7437
 

Classification Codes

Classification Codes

  • Anti-Anxiety Agents
  • Central Nervous System Agents
  • Central Nervous System Depressants
  • Drug / Therapeutic Agent
  • GABA Agents
  • GABA Modulators
  • Human Data
  • Hypnotics and Sedatives
  • Neurotransmitter Agents
  • Psychotropic Drugs
  • Tranquilizer (Minor)
  • Tranquilizing Agents
  • Tumor Data

Superlist Classification Codes

  • DEA Schedule IV
  • Overall Carcinogenic Evaluation: Group 3

Names and Synonyms

Name of Substance

  • Temazepam
  • Temazepam [USAN:USP:INN:BAN]

MeSH Heading

  • Temazepam

Synonyms

  • 1,3-Dihydro-7-chloro-3-hydroxy-1-methyl-5-phenyl-2H-1,4-benzodiazepin-2-one
  • 3-Hydroxydiazepam
  • 5-25-02-00242 (Beilstein Handbook Reference)
  • 7-Chloro-1,3-dihydro-3-hydroxy-1-methyl-5-phenyl-2H-1,4-benzodiazepin-2-one
  • BRN 0759300
  • CCRIS 1954
  • Cerepax
  • Crisonar
  • Dasuen
  • EINECS 212-688-1
  • ER 115
  • Euhypnos
  • Euipnos
  • Hydroxydiazepam
  • K-3917
  • K3917
  • Lenal
  • Levanxene
  • Levanxol
  • Mabertin
  • Methyloxazepam
  • N-Methyloxazepam
  • Neodorm SP
  • Nocturne
  • Nomapam
  • Norkotral Tema
  • Normison
  • Normitab
  • Nortem
  • NSC 246303
  • Oxydiazepam
  • Planum
  • Pronervon T
  • Remestan
  • Restoril
  • Ro 5-5345
  • Signopam
  • Strazepam
  • Temador
  • Temaz
  • temazep von ct
  • Temazepam
  • Temazepamum
  • Temazepamum [INN-Latin]
  • Temtabs
  • Tenox
  • UNII-CHB1QD2QSS
  • Uvamin Retard
  • WY 3917
  • Wy-3917

Systematic Names

  • 2H-1,4-Benzodiazepin-2-one, 7-chloro-1,3-dihydro-3-hydroxy-1-methyl-5-phenyl-
  • Temazepam

Superlist Names

  • DEA No. 2925
  • Temazepam

Registry Numbers

CAS Registry Number

  • 846-50-4

FDA UNII

  • CHB1QD2QSS

System Generated Number

  • 0000846504

Structure Descriptors

InChI

1S/C16H13ClN2O2/c1-19-13-8-7-11(17)9-12(13)14(18-15(20)16(19)21)10-5-3-2-4-6-10/h2-9,15,20H,1H3

InChIKey

SEQDDYPDSLOBDC-UHFFFAOYSA-N

Smiles

c12C(=NC(C(=O)N(c1ccc(c2)Cl)C)O)c1ccccc1

Toxicity

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
dog LD50 oral 3620mg/kg (3620mg/kg)   Drugs. International Journal of Current Therapeutics and Applied Pharmacology Reviews. Vol. 21, Pg. 321, 1981.
human TDLo oral 600ug/kg (0.6mg/kg) BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY) Human Psychopharmacology. Vol. 10, Pg. 449, 1995.
human TDLo oral 15430ug/kg/12 (15.43mg/kg) GASTROINTESTINAL: CHANGES IN STRUCTURE OR FUNCTION OF SALIVARY GLANDS

BEHAVIORAL: MUSCLE WEAKNESS
Arzneimittel-Forschung. Drug Research. Vol. 22, Pg. 93, 1972.
man TDLo oral 429ug/kg (0.429mg/kg) BEHAVIORAL: EXCITEMENT

BEHAVIORAL: REGIDITY
Journal of Clinical Psychiatry. Vol. 46, Pg. 280, 1985.
mouse LD50 intraperitoneal 85mg/kg (85mg/kg)   Archives Internationales de Pharmacodynamie et de Therapie. Vol. 185, Pg. 135, 1970.
mouse LD50 oral 370mg/kg (370mg/kg) BEHAVIORAL: ANTICONVULSANT European Journal of Pharmacology. Vol. 4, Pg. 467, 1968.
rat LD50 intraperitoneal 600mg/kg (600mg/kg)   Drugs. International Journal of Current Therapeutics and Applied Pharmacology Reviews. Vol. 21, Pg. 321, 1981.
rat LD50 oral 2gm/kg (2000mg/kg)   Drugs. International Journal of Current Therapeutics and Applied Pharmacology Reviews. Vol. 21, Pg. 321, 1981.
women TDLo oral 600ug/kg (0.6mg/kg) BEHAVIORAL: EXCITEMENT Journal of Clinical Psychiatry. Vol. 46, Pg. 280, 1985.

Physical Properties

Physical Property Value Units Temp (deg C) Source
Melting Point 119-121 deg C   EXP
log P (octanol-water) 2.19 (none)   EXP
Water Solubility 164 mg/L 25 EST
Vapor Pressure 2.14E-11 mm Hg 25 EST
Henry's Law Constant 1.13E-08 atm-m3/mole 25 EST
Atmospheric OH Rate Constant 1.44E-11 cm3/molecule-sec 25 EST

Physical property data is provided to ChemIDplus by SRC, Inc.