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Substance Name: Dotarizine [INN]
RN: 84625-59-2
UNII: IO7663S6D3
InChIKey: LRMJAFKKJLRDLE-UHFFFAOYSA-N

Note

  • 5-HT2 receptor antagonist; active metabolite, FI 6020, detected by gas chromatography.

Molecular Formula

  • C29-H34-N2-O2

Molecular Weight

  • 442.5996
 

Classification Codes

  • Calcium Channel Blockers
  • Cardiovascular Agents
  • Drug / Therapeutic Agent
  • Membrane Transport Modulators
  • Neurotransmitter Agents
  • Serotonin Agents
  • Serotonin Antagonists
  • Vasodilator Agents
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Names and Synonyms

Name of Substance

  • Dotarizine
  • Dotarizine [INN]

Synonyms

  • 1-(Diphenylmethyl)-4-(3-(2-phenyl-1,3-dioxolan-2-yl)propyl)piperazine
  • Dotarizina
  • Dotarizina [Spanish]
  • Dotarizine
  • Dotarizinum
  • Dotarizinum [Latin]
  • UNII-IO7663S6D3

Systematic Names

  • 1-(Diphenylmethyl)-4-(3-(2-phenyl-1,3-dioxolan-2-yl)propyl)piperazine
  • Piperazine, 1-(diphenylmethyl)-4-(3-(2-phenyl-1,3-dioxolan-2-yl)propyl)-

Registry Numbers

CAS Registry Number

  • 84625-59-2

FDA UNII

  • IO7663S6D3

System Generated Number

  • 0084625592

Structure Descriptors

InChI

1S/C29H34N2O2/c1-4-11-25(12-5-1)28(26-13-6-2-7-14-26)31-21-19-30(20-22-31)18-10-17-29(32-23-24-33-29)27-15-8-3-9-16-27/h1-9,11-16,28H,10,17-24H2

InChIKey

LRMJAFKKJLRDLE-UHFFFAOYSA-N

Smiles

c1ccc(cc1)C(c2ccccc2)N3CCN(CC3)CCCC4(OCCO4)c5ccccc5

Toxicity

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
mouse LD50 intravenous 42500ug/kg (42.5mg/kg)   Arzneimittel-Forschung. Drug Research. Vol. 37, Pg. 1103, 1987.
mouse LD50 oral > 8gm/kg (8000mg/kg)   Arzneimittel-Forschung. Drug Research. Vol. 37, Pg. 1103, 1987.