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Substance Name: Lormetazepam [USAN:INN:BAN:JAN]
RN: 848-75-9
UNII: GU56C842ZA
InChIKey: FJIKWRGCXUCUIG-UHFFFAOYSA-N

Molecular Formula

  • C16-H12-Cl2-N2-O2

Molecular Weight

  • 335.1888
 

Classification Codes

Classification Codes

  • Central Nervous System Agents
  • Central Nervous System Depressants
  • Hypnotics and Sedatives
  • Reproductive Effect
  • Sedative-Hypnotic

Superlist Classification Code

  • DEA Schedule IV
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Names and Synonyms

Name of Substance

  • Lormetazepam
  • Lormetazepam [USAN:INN:BAN:JAN]

Synonyms

  • 2H-1,4-Benzodiazepin-2-one, 7-chloro-5-(2-chlorophenyl)-1,3-dihydro-3-hydroxy-1-methyl-
  • 5-25-02-00251 (Beilstein Handbook Reference)
  • 7-Chloro-5-(2-chlorophenyl)-3-hydroxy-1-methyl-2,3-dihydro-1H-1,4-benzodiazepin-2-one
  • 7-Chloro-5-(o-chlorophenyl)-1,3-dihydro-3-hydroxy-1-methyl-2H-1,4-benzodiazepin-2-one
  • BRN 0759821
  • EINECS 212-700-5
  • Lormetazepam
  • Lormetazepamum
  • Lormetazepamum [INN-Latin]
  • Methyllorazepam
  • N-Methyllorazepam
  • Ro 5-5516
  • UNII-GU56C842ZA
  • WY 4082
  • WY-4082

Systematic Names

  • 2H-1,4-Benzodiazepin-2-one, 1,3-dihydro-7-chloro-5-(o-chlorophenyl)-3-hydroxy-1-methyl-
  • 2H-1,4-Benzodiazepin-2-one, 7-chloro-5-(2-chlorophenyl)-1,3-dihydro-3-hydroxy-1-methyl-
  • 7-Chloro-5-(2-chlorophenyl)-1,3-dihydro-3-hydroxy-1-methyl-2H-1,4-benzodiazepin-2-one
  • Lormetazepam

Superlist Names

  • DEA No. 2774
  • Lormetazepam
  • Noctamid

Registry Numbers

CAS Registry Number

  • 848-75-9

FDA UNII

  • GU56C842ZA

System Generated Number

  • 0000848759

Structure Descriptors

InChI

1S/C16H12Cl2N2O2/c1-20-13-7-6-9(17)8-11(13)14(19-15(21)16(20)22)10-4-2-3-5-12(10)18/h2-8,15,21H,1H3

InChIKey

FJIKWRGCXUCUIG-UHFFFAOYSA-N

Smiles

c12C(c3c(cccc3)Cl)=N[C@@H](O)C(N(c1ccc(c2)Cl)C)=O

Toxicity

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
mouse LD50 intraperitoneal 780mg/kg (780mg/kg) BEHAVIORAL: SLEEP

LUNGS, THORAX, OR RESPIRATION: RESPIRATORY DEPRESSION

KIDNEY, URETER, AND BLADDER: URINE VOLUME INCREASED
Yakuri to Chiryo. Pharmacology and Therapeutics. Vol. 13(Suppl,
mouse LD50 oral 1790mg/kg (1790mg/kg) KIDNEY, URETER, AND BLADDER: URINE VOLUME INCREASED

BEHAVIORAL: SLEEP

LUNGS, THORAX, OR RESPIRATION: RESPIRATORY DEPRESSION
Yakuri to Chiryo. Pharmacology and Therapeutics. Vol. 13(Suppl,
mouse LD50 subcutaneous > 10gm/kg (10000mg/kg) LUNGS, THORAX, OR RESPIRATION: DYSPNEA Yakuri to Chiryo. Pharmacology and Therapeutics. Vol. 13(Suppl,
rat LD50 intraperitoneal 6250mg/kg (6250mg/kg) KIDNEY, URETER, AND BLADDER: URINE VOLUME INCREASED

BEHAVIORAL: SLEEP

LUNGS, THORAX, OR RESPIRATION: RESPIRATORY DEPRESSION
Yakuri to Chiryo. Pharmacology and Therapeutics. Vol. 13(Suppl,
rat LD50 oral > 10gm/kg (10000mg/kg) SKIN AND APPENDAGES (SKIN): HAIR: OTHER

SENSE ORGANS AND SPECIAL SENSES: MIOSIS (PUPILLARY CONSTRICTION): EYE

BEHAVIORAL: SLEEP
Yakuri to Chiryo. Pharmacology and Therapeutics. Vol. 13(Suppl,
rat LD50 subcutaneous > 10gm/kg (10000mg/kg) BEHAVIORAL: SLEEP

SENSE ORGANS AND SPECIAL SENSES: MIOSIS (PUPILLARY CONSTRICTION): EYE

SKIN AND APPENDAGES (SKIN): HAIR: OTHER
Yakuri to Chiryo. Pharmacology and Therapeutics. Vol. 13(Suppl,

Physical Properties

Physical Property Value Units Temp (deg C) Source
Melting Point 206 deg C   EXP
log P (octanol-water) 2.230 (none)   EST
Atmospheric OH Rate Constant 1.18E-11 cm3/molecule-sec 25 EST

Physical property data is provided to ChemIDplus by SRC, Inc.