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Substance Name: Ritipenem [INN]
RN: 84845-57-8
UNII: D4SL77931L
InChIKey: IKQNRQOUOZJHTR-UWBRJAPDSA-N

Note

  • Carbapenem antibiotic.

Classification Code

  • Drug / Therapeutic Agent

Molecular Formula

  • C10-H12-N2-O6-S

Molecular Weight

  • 288.2788
 
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Names and Synonyms

Name of Substance

  • Ritipenem
  • Ritipenem [INN]

Synonyms

  • (5R,6S)-6-((1R)-1-Hydroxyethyl)-3-(hydroxymethyl)-7-oxo-4-thia-1-azabicyclo(3.2.0)hept-2-ene-2-carboxylic acid, 3-carbamate
  • Ritipenem
  • UNII-D4SL77931L

Systematic Names

  • (5R,6S)-6-((1R)-1-Hydroxyethyl)-3-(hydroxymethyl)-7-oxo-4-thia-1-azabicyclo(3.2.0)hept-2-ene-2-carboxylic acid, 3-carbamate
  • 4-Thia-1-azabicyclo(3.2.0)hept-2-ene-2-carboxylic acid, 3-(((aminocarbonyl)oxy)methyl)-6-(1-hydroxyethyl)-7-oxo-, (5R-(5alpha,6alpha(R*)))-

Registry Numbers

CAS Registry Number

  • 84845-57-8

FDA UNII

  • D4SL77931L

Related Registry Number

  • 84845-58-9 (Parent)

System Generated Number

  • 0084845578

Structure Descriptors

InChI

1S/C10H12N2O6S/c1-3(13)5-7(14)12-6(9(15)16)4(19-8(5)12)2-18-10(11)17/h3,5,8,13H,2H2,1H3,(H2,11,17)(H,15,16)/t3-,5+,8-/m1/s1

InChIKey

IKQNRQOUOZJHTR-UWBRJAPDSA-N

Smiles

C[C@H]([C@@H]1[C@@H]2N(C1=O)C(=C(S2)COC(=O)N)C(=O)O)O

Toxicity

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
rabbit LD intravenous > 1gm/kg (1000mg/kg) KIDNEY, URETER, AND BLADDER: "CHANGES IN TUBULES (INCLUDING ACUTE RENAL FAILURE, ACUTE TUBULAR NECROSIS)"

BLOOD: "CHANGES IN SERUM COMPOSITION (E.G., TP, BILIRUBIN, CHOLESTEROL)"
Kiso to Rinsho. Clinical Report. Vol. 29, Pg. 3475, 1995.