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Substance Name: Niperotidine [INN]
RN: 84845-75-0
UNII: 12JBD7U72K
InChIKey: HXRSXEDVVARPHP-UHFFFAOYSA-N

Classification Codes

  • Drug / Therapeutic Agent
  • Human Data

Molecular Formula

  • C20-H26-N4-O5-S

Molecular Weight

  • 434.5144
 
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Names and Synonyms

Name of Substance

  • Niperotidine
  • Niperotidine [INN]

Synonyms

  • EINECS 284-304-0
  • N-(2-((5-((Dimethylamino)methyl)furfuryl)thio)ethyl)-2-nitro-N'-piperonyl-1,1-ethenediamine
  • Niperotidina
  • Niperotidina [Spanish]
  • Niperotidine
  • Niperotidinum
  • Niperotidinum [Latin]
  • Piperonyl-ranitidine
  • UNII-12JBD7U72K

Systematic Names

  • 1,1-Ethenediamine, N-(1,3-benzodioxol-5-ylmethyl)-N'-(2-(((5-((dimethylamino)methyl)-2-furanyl)methyl)thio)ethyl)-2-nitro-
  • N-(1,3-Benzodioxol-5-ylmethyl)-N'-(2-((5-((dimethylamino)methyl)furfuryl)thio)ethyl)-2-nitrovinylidenediamine
  • N-(2-((5-((Dimethylamino)methyl)furfuryl)thio)ethyl)-2-nitro-N'-piperonyl-1,1-ethenediamine

Registry Numbers

CAS Registry Number

  • 84845-75-0

FDA UNII

  • 12JBD7U72K

System Generated Number

  • 0084845750

Structure Descriptors

InChI

1S/C20H26N4O5S/c1-23(2)11-16-4-5-17(29-16)13-30-8-7-21-20(12-24(25)26)22-10-15-3-6-18-19(9-15)28-14-27-18/h3-6,9,12,21-22H,7-8,10-11,13-14H2,1-2H3

InChIKey

HXRSXEDVVARPHP-UHFFFAOYSA-N

Smiles

CN(C)Cc1oc(CSCCNC(=C[N+](=O)[O-])NCc2ccc3OCOc3c2)cc1

Toxicity

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
man TDLo oral 230mg/kg/60D- (230mg/kg) LIVER: "JAUNDICE, CHOLESTATIC"

LIVER: LIVER FUNCTION TESTS IMPAIRED
Journal of Hepathology. Vol. 27, Pg. 583, 1997.
women TDLo oral 138mg/kg/15D- (138mg/kg) LIVER: "HEPATITIS (HEPATOCELLULAR NECROSIS), ZONAL"

LIVER: "JAUNDICE, CHOLESTATIC"

LIVER: LIVER FUNCTION TESTS IMPAIRED
Journal of Hepathology. Vol. 27, Pg. 583, 1997.
women TDLo oral 317mg/kg/69D- (317mg/kg) LIVER: "HEPATITIS (HEPATOCELLULAR NECROSIS), ZONAL"

LIVER: LIVER FUNCTION TESTS IMPAIRED
Journal of Hepathology. Vol. 27, Pg. 583, 1997.