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Substance Name: Cabozantinib [USAN:INN]
RN: 849217-68-1
UNII: 1C39JW444G
InChIKey: ONIQOQHATWINJY-UHFFFAOYSA-N

Notes

  • A multikinase inhibitor.
  • A multikinase inhibitor.

    NCI: An orally bioavailable, small molecule receptor tyrosine kinase (RTK) inhibitor with potential antineoplastic activity. Cabozantinib strongly binds to and inhibits several tyrosine receptor kinases. Specifically, cabozantinib appears to have a strong affinity for the hepatocyte growth factor receptor (Met) and vascular endothelial growth factor receptor 2 (VEGFR2), which may result in inhibition of tumor growth and angiogenesis, and tumor regression. This agent has also been shown to inhibit mast/stem cell growth factor (KIT), FMS-like tyrosine kinase 3 (Flt3) and tyrosine-protein kinase receptor (Tie-2). (NCI Thesaurus)

Molecular Formula

  • C28-H24-F-N3-O5

Molecular Weight

  • 501.5116
 

Classification Code

  • Antineoplastic

Names and Synonyms

Name of Substance

  • Cabozantinib
  • Cabozantinib [USAN:INN]

Synonyms

  • BMS 907351
  • BMS-907351
  • Cabozantinib
  • Cometriq
  • UNII-1C39JW444G
  • XL 184
  • XL-184
  • XL184

Systematic Name

  • 1,1-Cyclopropanedicarboxamide, N'-(4-((6,7-dimethoxy-4-quinolinyl)oxy]phenyl]-N-(4- fluorophenyl)-

Registry Numbers

CAS Registry Number

  • 849217-68-1

FDA UNII

  • 1C39JW444G

System Generated Number

  • 0849217681

Structure Descriptors

InChI

1S/C28H24FN3O5/c1-35-24-15-21-22(16-25(24)36-2)30-14-11-23(21)37-20-9-7-19(8-10-20)32-27(34)28(12-13-28)26(33)31-18-5-3-17(29)4-6-18/h3-11,14-16H,12-13H2,1-2H3,(H,31,33)(H,32,34)

InChIKey

ONIQOQHATWINJY-UHFFFAOYSA-N

Smiles

COc1cc2c(ccnc2cc1OC)Oc3ccc(cc3)NC(=O)C4(CC4)C(=O)Nc5ccc(cc5)F