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Substance Name: (-)-Gusperimus trihydrochloride
RN: 84937-45-1
UNII: S0D7V00ZRX
InChIKey: AXSPHUWXYSZPBG-OKUPDQQSSA-N

Note

  • Synthesized by chemical modification of spergualin; in combination with cyclosporin A prevents diabetes in predisposed NOD mice.

Molecular Formula

  • C17-H37-N7-O3.3Cl-H

Molecular Weight

  • 496.908
 

Classification Codes

  • Antibiotics, Antineoplastic
  • Antineoplastic Agents
  • Drug / Therapeutic Agent
  • Hypoglycemic Agents
  • Immunologic Factors
  • Immunosuppressive Agents
  • Protective Agents
  • Radiation-Protective Agents
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Names and Synonyms

Results Name

  • (-)-Gusperimus trihydrochloride

Name of Substance

  • Gusperimus
  • Gusperimus (-)-form trihydrochloride
  • Gusperimus hydrochloride

Synonyms

  • (-)-(15S)-1-Amino-19-guanidino-11,15-dihydroxy-4,9,12-triazanonadecane-10,13-dione 3HCl
  • (-)-15-Deoxyspergualin trihydrochloride
  • (-)-Gusperimus trihydrochloride
  • Deoxyspergualin trihydrochloride
  • Gusperimus (-)-form trihydrochloride
  • Gusperimus HCl
  • UNII-S0D7V00ZRX

Systematic Names

  • Heptanamide, 7-((aminoiminomethyl)amino)-N-((1S)-2-((4-((3-aminopropyl)amino)butyl)amino)-1-hydroxy-2-oxoethyl)-, trihydrochloride
  • Heptanamide, 7-((aminoiminomethyl)amino)-N-(2-((4-((3-aminopropyl)amino)butyl)amino)-1-hydroxy-2-oxoethyl)-, trihydrochloride, (-)-
  • Heptanamide, 7-((aminoiminomethyl)amino)-N-(2-((4-((3-aminopropyl)amino)butyl)amino)-1-hydroxy-2-oxoethyl)-, trihydrochloride, (S)-

Registry Numbers

CAS Registry Number

  • 84937-45-1

FDA UNII

  • S0D7V00ZRX

Related Registry Number

  • 85468-01-5 (3HCl)

System Generated Number

  • 0084937451

Molecular Formulas

Molecular Formula

  • C17-H37-N7-O3.3Cl-H

Molecular Formula Fragments

  • C17-H37-N7-O3
  • Cl-H
  • COMPONENT

Structure Descriptors

InChI

1S/C17H37N7O3.3ClH/c18-9-7-11-21-10-5-6-12-22-15(26)16(27)24-14(25)8-3-1-2-4-13-23-17(19)20;;;/h16,21,27H,1-13,18H2,(H,22,26)(H,24,25)(H4,19,20,23);3*1H/t16-;;;/m0.../s1

InChIKey

AXSPHUWXYSZPBG-OKUPDQQSSA-N

Smiles

C(CCCNC(=N)N)CCC(=O)N[C@H](C(=O)NCCCCNCCCN)O.Cl.Cl.Cl

Toxicity

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
mouse LD50 intraperitoneal 35mg/kg (35mg/kg)   Journal of Antibiotics. Vol. 35, Pg. 1665, 1982.
mouse LD50 intravenous 35mg/kg (35mg/kg)   Journal of Antibiotics. Vol. 35, Pg. 1665, 1982.