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Substance Name: Brovincamine fumarate [JAN]
RN: 84964-12-5
UNII: Y3SNC78UTU
InChIKey: CKCVTPQYFOMHFD-HPJCWFBOSA-N

Classification Codes

  • Drug / Therapeutic Agent
  • Reproductive Effect

Molecular Formula

  • C21-H25-Br-N2-O3.C4-H4-O4

Molecular Weight

  • 549.415
 
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Names and Synonyms

Name of Substance

  • Brovincamine fumarate [JAN]
  • Brovincamine hydogen fumurate

Synonyms

  • 11-Bromovincamine fumarate
  • Brovincamine fumarate
  • UNII-Y3SNC78UTU

Systematic Name

  • Eburnamenine-14-carboxylic acid, 14,15-dihydro-11-bromo-14-hydroxy-, methyl ester, (3-alpha,14-beta,16-alpha)-, (E)-2-butenedioate (1:1) (salt)

Registry Numbers

CAS Registry Number

  • 84964-12-5

FDA UNII

  • Y3SNC78UTU

Related Registry Number

  • 57475-17-9 (Parent)

System Generated Number

  • 0084964125

Molecular Formulas

Molecular Formula

  • C21-H25-Br-N2-O3.C4-H4-O4

Molecular Formula Fragments

  • C21-H25-Br-N2-O3
  • C4-H4-O4
  • COMPONENT

Structure Descriptors

InChI

1S/C21H25BrN2O3.C4H4O4/c1-3-20-8-4-9-23-10-7-15-14-6-5-13(22)11-16(14)24(17(15)18(20)23)21(26,12-20)19(25)27-2;5-3(6)1-2-4(7)8/h5-6,11,18,26H,3-4,7-10,12H2,1-2H3;1-2H,(H,5,6)(H,7,8)/b;2-1+/t18-,20+,21+;/m1./s1

InChIKey

CKCVTPQYFOMHFD-HPJCWFBOSA-N

Smiles

c12c3c4[C@@H]5[C@](CCC[N@@]5CC3)(CC)C[C@](O)(C(OC)=O)n4c1cc(Br)cc2.C(=C\C(O)=O)\C(O)=O

Toxicity

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
mouse LD50 intravenous 75400ug/kg (75.4mg/kg) LUNGS, THORAX, OR RESPIRATION: CYANOSIS

LUNGS, THORAX, OR RESPIRATION: DYSPNEA

BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD
Kiso to Rinsho. Clinical Report. Vol. 17, Pg. 951, 1983.
mouse LD50 oral 2553mg/kg (2553mg/kg) LUNGS, THORAX, OR RESPIRATION: CYANOSIS

BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD

LUNGS, THORAX, OR RESPIRATION: DYSPNEA
Kiso to Rinsho. Clinical Report. Vol. 17, Pg. 951, 1983.
mouse LD50 subcutaneous > 1gm/kg (1000mg/kg) SENSE ORGANS AND SPECIAL SENSES: LACRIMATION: EYE

SKIN AND APPENDAGES (SKIN): "DERMATITIS, OTHER: AFTER SYSTEMIC EXPOSURE"
Kiso to Rinsho. Clinical Report. Vol. 17, Pg. 951, 1983.
rabbit LD50 intravenous 28600ug/kg (28.6mg/kg)   Iyakuhin Kenkyu. Study of Medical Supplies. Vol. 17, Pg. 365, 1986.
rabbit LD50 oral 461mg/kg (461mg/kg)   Iyakuhin Kenkyu. Study of Medical Supplies. Vol. 17, Pg. 365, 1986.
rat LD50 intravenous 45100ug/kg (45.1mg/kg) LUNGS, THORAX, OR RESPIRATION: DYSPNEA

BEHAVIORAL: ATAXIA

LUNGS, THORAX, OR RESPIRATION: CYANOSIS
Kiso to Rinsho. Clinical Report. Vol. 17, Pg. 951, 1983.
rat LD50 oral 1743mg/kg (1743mg/kg) BEHAVIORAL: ATAXIA

BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD

SENSE ORGANS AND SPECIAL SENSES: MYDRIASIS (PUPILLARY DILATION): EYE
Kiso to Rinsho. Clinical Report. Vol. 17, Pg. 951, 1983.
rat LD50 subcutaneous > 1gm/kg (1000mg/kg) SKIN AND APPENDAGES (SKIN): "DERMATITIS, OTHER: AFTER SYSTEMIC EXPOSURE"

SENSE ORGANS AND SPECIAL SENSES: LACRIMATION: EYE
Kiso to Rinsho. Clinical Report. Vol. 17, Pg. 951, 1983.