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Substance Name: Phthalylsulfathiazole [USP:INN:BAN]
RN: 85-73-4
UNII: 6875L5852V
InChIKey: PBMSWVPMRUJMPE-UHFFFAOYSA-N

Classification Code

  • Drug / Therapeutic Agent

Molecular Formula

  • C17-H13-N3-O5-S2

Molecular Weight

  • 403.4377
 
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Names and Synonyms

Name of Substance

  • Phthalylsulfathiazole
  • Phthalylsulfathiazole [USP:INN:BAN]

Synonyms

  • (o-Carboxybenzoyl)-p-aminophenylsulfonamidothiazole
  • 2-(N(sup 4)-Phthalyaminobenzenesulfonamide)thiazole
  • 2-(N(sup 4)-Phthalyaminobenzenesulfonamido)thiazole
  • 2-(N(sup 4)-Phthalylsulfanilamido)thiazole
  • 2-(N(sup4)-Phthalylsulfanilamido)thiazole
  • 2-(N4-Phthalylaminobenzenesulfonamide)thiazole
  • 2-(p-N-Phthalylsulfanilyl)aminothiazole
  • 2-(p-Phthalylaminobenzenesulfamido)thiazole
  • 4'-(2-Thiazolylsulfamoyl)phthalanilic acid
  • 4'-(2-Thiazolylsulfamyl)phthalanilic acid
  • AFI-Ftalyl
  • AI3-18632
  • Benzoic acid, 2-(((4-((2-thiazolylamino)sulfonyl)phenyl)amino)carbonyl)-
  • Cremothalidine
  • EC 201-627-4
  • EINECS 201-627-4
  • Enteramida
  • Entero-sulfina
  • Entexidin
  • Entexidina
  • Ftalazol
  • Ftalil-Esteve
  • Ftalil-Septol
  • Ftalilsofatiazolo
  • Ftalilsofatiazolo [DCIT]
  • Ftalilsulfatiazol
  • Ftalilsulfatiazol [INN-Spanish]
  • Ftalylsulfathiazol
  • Ftalylsulfathiazol [Czech]
  • Ftalysept
  • Intestiazol
  • NSC 66454
  • NSC 683525
  • Phtalazol
  • Phtalylsulfathiazol
  • Phtalylsulfathiazol [INN-French]
  • Phthalazol
  • Phthalazole
  • Phthalazolum
  • Phthalidin
  • Phthaloylsulfathiazole
  • Phthalylnorsulfazole
  • Phthalylsulfathiazole
  • Phthalylsulfathiazolum
  • Phthalylsulfathiazolum [INN-Latin]
  • Phthalylsulfonazole
  • Phthalylsulphathiazole
  • Sulfacetil
  • Sulfanilamide, N(sup 4)-(o-carboxybenzoyl)-N'-2-thiazolyl-
  • Sulfaphthalazole
  • Sulfathalidine
  • Sulftalyl
  • Sulphaphthalyl
  • Taleudron
  • Talidine
  • Taloudron
  • Thalazole
  • Thalinil
  • Thalistanin
  • Thalistatyl
  • Ultratiazol
  • UNII-6875L5852V

Systematic Names

  • Benzoic acid, 2-(((4-((2-thiazolylamino)sulfonyl)phenyl)amino)carbonyl)-
  • Phthalanilic acid, 4'-(2-thiazolylsulfamoyl)-
  • Phthalylsulfathiazole

Registry Numbers

CAS Registry Number

  • 85-73-4

FDA UNII

  • 6875L5852V

Related Registry Number

  • 63868-70-2 (mono-hydrochloride salt)

System Generated Number

  • 0000085734

Structure Descriptors

InChI

1S/C17H13N3O5S2/c21-15(13-3-1-2-4-14(13)16(22)23)19-11-5-7-12(8-6-11)27(24,25)20-17-18-9-10-26-17/h1-10H,(H,18,20)(H,19,21)(H,22,23)

InChIKey

PBMSWVPMRUJMPE-UHFFFAOYSA-N

Smiles

c1(c(cccc1)C(=O)O)C(=O)Nc1ccc(cc1)S(=O)(=O)Nc1nccs1

Toxicity

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
mouse LD oral > 10gm/kg (10000mg/kg)   Journal of Pharmacology and Experimental Therapeutics. Vol. 81, Pg. 116, 1944.
mouse LD50 intraperitoneal 920mg/kg (920mg/kg)   Journal of Pharmacology and Experimental Therapeutics. Vol. 81, Pg. 116, 1944.
rat LD unreported > 10gm/kg (10000mg/kg)   Gigiena i Sanitariya. For English translation, see HYSAAV. Vol. 58(12), Pg. 9, 1993.

Physical Properties

Physical Property Value Units Temp (deg C) Source
Melting Point 273 deg C   EXP
log P (octanol-water) 0.880 (none)   EST
Water Solubility 590 mg/L 37 EXP
Atmospheric OH Rate Constant 1.02E-10 cm3/molecule-sec 25 EST

Physical property data is provided to ChemIDplus by SRC, Inc.