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Substance Name: Fluprofylline [INN]
RN: 85118-43-0
UNII: 6Y42K4JRBJ
InChIKey: IPSYNNODBHPDFB-UHFFFAOYSA-N

Note

  • Has blood pressure lowering, serotonin & histamine antagonistic & broncholytic activity.

Classification Code

  • Drug / Therapeutic Agent

Molecular Formula

  • C22-H26-F-N5-O3

Molecular Weight

  • 427.4774
 
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Names and Synonyms

Name of Substance

  • Fluprofylline [INN]
  • Fluprophylline

Synonyms

  • 1H-Purine-2,6-dione, 7-(3-(4-(4-fluorobenzoyl)-1-piperidinyl)propyl)-3,7-dihydro-1,3-dimethyl-
  • 7-(3-(4-(p-Fluorobenzoyl)piperidino)propyl)theophylline
  • Fluprofilina
  • Fluprofilina [Spanish]
  • Fluprofylline
  • Fluprofyllinum
  • Fluprofyllinum [Latin]
  • Sgd 144 80
  • UNII-6Y42K4JRBJ

Systematic Names

  • 1H-Purine-2,6-dione, 7-(3-(4-(4-fluorobenzoyl)-1-piperidinyl)propyl)-3,7-dihydro-1,3-dimethyl-
  • 7-(3-(4-(p-Fluorobenzoyl)piperidino)propyl)theophylline
  • Theophylline, 7-(3-(4-(p-fluorobenzoyl)piperidino)propyl)-

Registry Numbers

CAS Registry Number

  • 85118-43-0

FDA UNII

  • 6Y42K4JRBJ

System Generated Number

  • 0085118430

Structure Descriptors

InChI

1S/C22H26FN5O3/c1-25-20-18(21(30)26(2)22(25)31)28(14-24-20)11-3-10-27-12-8-16(9-13-27)19(29)15-4-6-17(23)7-5-15/h4-7,14,16H,3,8-13H2,1-2H3

InChIKey

IPSYNNODBHPDFB-UHFFFAOYSA-N

Smiles

Cn1c2c(c(=O)n(c1=O)C)n(cn2)CCCN3CCC(CC3)C(=O)c4ccc(cc4)F

Toxicity

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
mouse LD50 intravenous 51mg/kg (51mg/kg) BEHAVIORAL: ALTERED SLEEP TIME (INCLUDING CHANGE IN RIGHTING REFLEX)

SENSE ORGANS AND SPECIAL SENSES: PTOSIS: EYE

BEHAVIORAL: ATAXIA
Arzneimittel-Forschung. Drug Research. Vol. 34, Pg. 1, 1984.
mouse LD50 oral 790mg/kg (790mg/kg) BEHAVIORAL: ALTERED SLEEP TIME (INCLUDING CHANGE IN RIGHTING REFLEX)

SENSE ORGANS AND SPECIAL SENSES: PTOSIS: EYE

BEHAVIORAL: ATAXIA
Arzneimittel-Forschung. Drug Research. Vol. 34, Pg. 1, 1984.