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Substance Name: Cefpimizole sodium [USAN:JAN]
RN: 85287-61-2
UNII: X4628IMC52
InChIKey: JLUNZNNMKVKUOH-TZVBBFNXSA-M

Note

  • Semisynthetic cephalosporin.

Classification Codes

  • Antibacterial
  • Drug / Therapeutic Agent

Molecular Formula

  • C28-H26-N6-O10-S2.Na

Molecular Weight

  • 692.6595
 
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Names and Synonyms

Name of Substance

  • AC 1370
  • Cefpimizole monosodium salt
  • Cefpimizole sodium [USAN:JAN]

Synonyms

  • 1-(((6R,7R)-2-Carboxy-7-((R)-2-(5-carboxyimidazole-4-carboxamido)-2-phenylacetamido)-8-oxo-5-thia-1-azabicyclo(4.2.0)oct-2-en-3-yl)methyl)-4-(2-sulfoethyl)pyridinium hydroxide, inner salt, monosodium salt
  • AC 1370
  • AC 1370 sodium
  • Ajicef
  • Cefpimizole sodium
  • Pyridinium, 1-((2-carboxy-7-(((((5-carboxy-1H-imidazol-4-yl)carbonyl)amino)phenylacetyl)amino)-8-oxo-5-thia-1-azabicyclo(4.2.0)oct-2-en-3-yl)methyl)-4-(2-sulfoethyl)-, hydroxide, inner salt, monosodium salt, (6R-(6alpha,7beta(R*)))-
  • Renilan
  • U 63196E
  • U-63,196E
  • UNII-X4628IMC52

Systematic Name

  • Pyridinium, 1-((2-carboxy-7-(((((5-carboxy-1H-imidazol-4-yl)carbonyl)amino)phenylacetyl)amino)-8-oxo-5-thia-1-azabicyclo(4.2.0)oct-2-en-3-yl)methyl)-4-(2-sulfoethyl)-, hydroxide, inner salt, monosodium salt, (6R-(6alpha,7beta(R*)))-

Registry Numbers

CAS Registry Number

  • 85287-61-2

FDA UNII

  • X4628IMC52

System Generated Number

  • 0085287612

Molecular Formulas

Molecular Formula

  • C28-H26-N6-O10-S2.Na

Molecular Formula Fragments

  • C28-H26-N6-O10-S2
  • COMPONENT
  • Na

Structure Descriptors

InChI

1S/C28H26N6O10S2.Na/c35-23(18(16-4-2-1-3-5-16)31-24(36)19-20(27(38)39)30-14-29-19)32-21-25(37)34-22(28(40)41)17(13-45-26(21)34)12-33-9-6-15(7-10-33)8-11-46(42,43)44;/h1-7,9-10,14,18,21,26H,8,11-13H2,(H5-,29,30,31,32,35,36,38,39,40,41,42,43,44);/q;+1/p-1/t18-,21+,26+;/m0./s1

InChIKey

JLUNZNNMKVKUOH-TZVBBFNXSA-M

Smiles

c1ccc(cc1)[C@@H](C(=O)N[C@H]2[C@@H]3N(C2=O)C(=C(CS3)C[n+]4ccc(cc4)CCS(=O)(=O)[O-])C(=O)[O-])NC(=O)c5c([nH]cn5)C(=O)O.[Na+]

Toxicity

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
mouse LD50 intramuscular > 1200mg/kg (1200mg/kg)   Toxicology Letters. Vol. 23, Pg. 135, 1984.
mouse LD50 intravenous 2700mg/kg (2700mg/kg) LUNGS, THORAX, OR RESPIRATION: CYANOSIS

LUNGS, THORAX, OR RESPIRATION: DYSPNEA
Toxicology Letters. Vol. 23, Pg. 135, 1984.
mouse LD50 oral > 15gm/kg (15000mg/kg)   Toxicology Letters. Vol. 23, Pg. 135, 1984.
mouse LD50 subcutaneous 6800mg/kg (6800mg/kg) BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY) Toxicology Letters. Vol. 23, Pg. 135, 1984.
rat LD50 intramuscular > 1200mg/kg (1200mg/kg)   Toxicology Letters. Vol. 23, Pg. 135, 1984.
rat LD50 intravenous 3500mg/kg (3500mg/kg) LUNGS, THORAX, OR RESPIRATION: DYSPNEA

LUNGS, THORAX, OR RESPIRATION: CYANOSIS
Toxicology Letters. Vol. 23, Pg. 135, 1984.
rat LD50 oral > 15gm/kg (15000mg/kg)   Toxicology Letters. Vol. 23, Pg. 135, 1984.
rat LD50 subcutaneous 11500mg/kg (11500mg/kg) BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY) Toxicology Letters. Vol. 23, Pg. 135, 1984.