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Substance Name: Naftidrofuryl citrate
RN: 85293-34-1
UNII: 1BB8I7MT98
InChIKey: LKLQMEYKQKAQCX-UHFFFAOYSA-N

Note

  • A drug used in the management of peripheral and cerebral vascular disorders. It is claimed to enhance cellular oxidative capacity and to be a spasmolytic. (From Martindale, The Extra Pharmacopoeia, 30th ed, p1310) It may also be an antagonist at 5HT-2 serotonin receptors.

Molecular Formula

  • C24-H33-N-O3.C6-H8-O7

Molecular Weight

  • 575.651
 

Classification Code

  • Drug / Therapeutic Agent
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Names and Synonyms

Results Name

  • Naftidrofuryl citrate

Name of Substance

  • Nafronyl citrate

Synonyms

  • EINECS 286-639-8
  • Naftidrofuryl citrate
  • UNII-1BB8I7MT98

Systematic Names

  • 2-Furanpropanoic acid, tetrahydro-alpha-(1-naphthalenylmethyl)-, 2-(diethylamino)ethyl ester,2-hydroxy-1,2,3-propanetricarboxylate (1:1)
  • Diethyl(2-(3-(2-furyl)-2-(2-naphthylmethyl)propionyloxy)ethyl)ammonium dihydrogen citrate

Registry Numbers

CAS Registry Number

  • 85293-34-1

FDA UNII

  • 1BB8I7MT98

System Generated Number

  • 0085293341

Molecular Formulas

Molecular Formula

  • C24-H33-N-O3.C6-H8-O7

Molecular Formula Fragments

  • C24-H33-N-O3
  • C6-H8-O7
  • COMPONENT

Structure Descriptors

InChI

1S/C24H33NO3.C6H8O7/c1-3-25(4-2)14-16-28-24(26)21(18-22-12-8-15-27-22)17-20-11-7-10-19-9-5-6-13-23(19)20;7-3(8)1-6(13,5(11)12)2-4(9)10/h5-7,9-11,13,21-22H,3-4,8,12,14-18H2,1-2H3;13H,1-2H2,(H,7,8)(H,9,10)(H,11,12)

InChIKey

LKLQMEYKQKAQCX-UHFFFAOYSA-N

Smiles

O1[C@@H](CCC1)C[C@@H](Cc1cccc2ccccc12)C(=O)OCCN(CC)CC.C(C(CC(=O)O)(C(=O)O)O)C(=O)O

Toxicity

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
mouse LD50 intravenous 22280ug/kg (22.28mg/kg)   United States Patent Document. Vol. #4439442,
mouse LD50 oral 1225mg/kg (1225mg/kg)   United States Patent Document. Vol. #4439442,
rat LD50 intravenous 13560ug/kg (13.56mg/kg)   United States Patent Document. Vol. #4439442,
rat LD50 oral 3394mg/kg (3394mg/kg)   United States Patent Document. Vol. #4439442,