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Substance Name: Blinatumomab [USAN:INN]
RN: 853426-35-4
UNII: 4FR53SIF3A

Notes

  • A single-chain bispecific recombinant antibody from Micromet's BiTE (bispecific T-cell engager) product platform that binds both the CD19 antigen and the T-cell receptor (CD3), for the potential treatment of B-cell lymphoma.
  • A single-chain bispecific recombinant antibody from Micromets BiTE (bispecific T-cell engager) product platform that binds both the CD19 antigen and the T-cell receptor (CD3), for the potential treatment of B-cell lymphoma.

    NCI: A recombinant, single-chain, anti-CD19/anti-CD3 bispecific monoclonal antibody with potential immunostimulating and antineoplastic activities. Blinatumomab posesses two antigen-recognition sites, one for the CD3 complex, a group of T cell surface glycoproteins that complex with the T cell receptor (TCR), and one for CD19, a tumor-associated antigen (TAA) overexpressed on the surface of B cells. This bispecific monoclonal antibody brings CD19-expressing tumor B-cells and cytotoxic T lymphocytes (CTLs) and helper T lymphocytes (HTLs) together, which may result in the CTL- and HTL-mediated cell death of CD19-expressing B-lymphocytes.(NCI Thesaurus)

Molecular Formula

  • C2367-H3577-N649-O772-S19
 

Classification Codes

  • Antineoplastic Agents
  • Treatment of Cancer

Names and Synonyms

Name of Substance

  • Blinatumomab
  • Blinatumomab [USAN:INN]

Synonyms

  • Antibody MT-103
  • Blinatumomab
  • Blincyto
  • Immunoglobulin, anti-(human B-lymphocyte antigen CD19 (Leu-12)) mouse monoclonal scFv fragment (IGKV-IGKJ-tetraglycyl-L-seryltetraglycyl-L-seryltetraglycyl-L-seryl-IGHV-IGHJ) fusion protein with tetraglycyl-L-serine fusion protein with immunoglobulin, anti-(human T-cell surface glycoprotein CD3 epsilon chain (Leu-4)) mouse monoclonal scFv fragment (IGHV-IGHJ-L-valyl-L-glutamyltetrakis(diglycyl-L-seryl)diglycyl-L-valyl-L-aspartyl-IGKV-IGKJ) fusion protein with hexa-L-histamine
  • MEDI-538
  • MT-103
  • MT-103 antibody
  • MT103
  • UNII-4FR53SIF3A

Systematic Names

  • Immunoglobulin, anti-(human B-lymphocyte antigen CD19 (Leu-12)) mouse monoclonal scFv fragment (IGKV-IGKJ-tetraglycyl-L-seryltetraglycyl-L-seryltetraglycyl- L-seryl-IGHV-IGHJ) fusion protein with tetraglycyl-L-serine fusion protein with immunoglobulin, anti-(human T-cell surface glycoprotein CD3 epsilon chain (Leu-4)) mouse monoclonal scFv fragment (IGHV-IGHJ-L-valyl-L-glutamyltetrakis(diglycyl-L- seryl)diglycyl-L-valyl-L-aspartyl-IGKV-IGKJ) fusion protein with hexa-L-histamine
  • Immunoglobulin, anti-(human CD19 (antigen)) (single-chain) fusion protein with immunoglobulin, anti-(human CD3 (antigen)) (clone 1 single-chain)

Registry Numbers

CAS Registry Number

  • 853426-35-4

FDA UNII

  • 4FR53SIF3A

System Generated Number

  • 0853426354