Substance Name: Blinatumomab [USAN:INN]
RN: 853426-35-4
UNII: 4FR53SIF3A

Notes

A single-chain bispecific recombinant antibody from Micromet's BiTE (bispecific T-cell engager) product platform that binds both the CD19 antigen and the T-cell receptor (CD3), for the potential treatment of B-cell lymphoma.
A single-chain bispecific recombinant antibody from Micromets BiTE (bispecific T-cell engager) product platform that binds both the CD19 antigen and the T-cell receptor (CD3), for the potential treatment of B-cell lymphoma.

NCI: A recombinant, single-chain, anti-CD19/anti-CD3 bispecific monoclonal antibody with potential immunostimulating and antineoplastic activities. Blinatumomab posesses two antigen-recognition sites, one for the CD3 complex, a group of T cell surface glycoproteins that complex with the T cell receptor (TCR), and one for CD19, a tumor-associated antigen (TAA) overexpressed on the surface of B cells. This bispecific monoclonal antibody brings CD19-expressing tumor B-cells and cytotoxic T lymphocytes (CTLs) and helper T lymphocytes (HTLs) together, which may result in the CTL- and HTL-mediated cell death of CD19-expressing B-lymphocytes.(NCI Thesaurus)

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Immunoglobulin, anti-(human B-lymphocyte antigen CD19 (Leu-12)) mouse monoclonal scFv fragment (IGKV-IGKJ-tetraglycyl-L-seryltetraglycyl-L-seryltetraglycyl-L-seryl-IGHV-IGHJ) fusion protein with tetraglycyl-L-serine fusion protein with immunoglobulin, anti-(human T-cell surface glycoprotein CD3 epsilon chain (Leu-4)) mouse monoclonal scFv fragment (IGHV-IGHJ-L-valyl-L-glutamyltetrakis(diglycyl-L-seryl)diglycyl-L-valyl-L-aspartyl-IGKV-IGKJ) fusion protein with hexa-L-histamine
MEDI-538

Immunoglobulin, anti-(human B-lymphocyte antigen CD19 (Leu-12)) mouse monoclonal scFv fragment {IGKV-IGKJ-tetraglycyl-L-seryltetraglycyl-L-seryltetraglycyl- L-seryl-IGHV-IGHJ} fusion protein with tetraglycyl-L-serine fusion protein with immunoglobulin, anti-(human T-cell surface glycoprotein CD3 ? chain (Leu-4)) mouse monoclonal scFv fragment {IGHV-IGHJ-L-valyl-L-glutamyltetrakis[diglycyl-L- seryl]diglycyl-L-valyl-L-aspartyl-IGKV-IGKJ} fusion protein with hexa-L-histamine

Immunoglobulin, anti-(human CD19 (antigen)) (single-chain) fusion protein with immunoglobulin, anti-(human CD3 (antigen)) (clone 1 single-chain)