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Substance Name: Naloxegol [USAN:INN]
RN: 854601-70-0
UNII: 44T7335BKE
InChIKey: XNKCCCKFOQNXKV-ZRSCBOBOSA-N

Notes

  • A mu-opioid receptor antagonist.
  • A peripherally acting opioid receptor antagonist specific for mu-opioid receptors. Used to decrease the constipating effects of opioids.
  • Treatment of opioid-induced constipation

Molecular Formula

  • C34-H53-N-O11

Molecular Weight

  • 651.7887
 

Classification Codes

  • Central Nervous System Agents
  • Narcotic Antagonists
  • Peripheral Nervous System Agents
  • Sensory System Agents

Names and Synonyms

Name of Substance

  • Naloxegol [USAN:INN]

Synonyms

  • AZ13337019
  • HSDB 8338
  • Movantik
  • Naloxegol
  • NKTR 118
  • NKTR-118
  • NKTR118
  • UNII-44T7335BKE

Systematic Name

  • Morphinan-3,14-diol, 4,5-epoxy-6-(3,6,9,12,15,18,21-heptaoxadocos-1-yloxy)- 17-(2-propenyl)-, (5alpha,6alpha)-

Registry Numbers

CAS Registry Number

  • 854601-70-0

FDA UNII

  • 44T7335BKE

System Generated Number

  • 0854601700

Structure Descriptors

InChI

1S/C34H53NO11/c1-3-9-35-10-8-33-30-26-4-5-27(36)31(30)46-32(33)28(6-7-34(33,37)29(35)25-26)45-24-23-44-22-21-43-20-19-42-18-17-41-16-15-40-14-13-39-12-11-38-2/h3-5,28-29,32,36-37H,1,6-25H2,2H3/t28-,29+,32-,33-,34+/m0/s1

InChIKey

XNKCCCKFOQNXKV-ZRSCBOBOSA-N

Smiles

COCCOCCOCCOCCOCCOCCOCCO[C@H]1CC[C@@]2(O)[C@H]3Cc4ccc(O)c5O[C@@H]1[C@]2(CCN3CC=C)c45