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Substance Name: Temozolomide [USAN:INN:BAN]
RN: 85622-93-1
UNII: YF1K15M17Y
InChIKey: BPEGJWRSRHCHSN-UHFFFAOYSA-N

Classification Codes

  • Alkylating Agents
  • Antineoplastic Agents
  • Antineoplastic Agents, Alkylating
  • Drug / Therapeutic Agent
  • Mutation Data
  • Noxae
  • Treatment of Recurrent High-Grade Gliomas and Advanced Metastatic Melanoma (Alkylating Agent)

Molecular Formula

  • C6-H6-N6-O2

Molecular Weight

  • 194.1534
 

Names and Synonyms

Name of Substance

  • Temozolomide
  • Temozolomide [USAN:INN:BAN]

Synonyms

  • 3,4-Dihydro-3-methyl-4-oxoimidazo(5,1-d)-1,2,3,5-tetrazine-8-carboxamide
  • 3,4-Dihydro-3-methyl-4-oxoimidazo(5,1-d)-as-tetrazine-8-carboxamide
  • 3-Methyl-4-oxo-3,4-dihydroimidazo(5,1-d)(1,2,3,5)tetrazine-8-carboxamide
  • 8-Carbamoyl-3-methylimidazo(5,1-d)-1,2,3,5-tetrazin-4(3H)-one
  • BRN 5547136
  • CCRG 81045
  • CCRG-81045
  • CCRIS 8996
  • M & B 39831
  • M&B 39831
  • MB 39831
  • Methazolastone
  • NSC 362856
  • Sch 52365
  • Temodal
  • Temodar
  • Temozolodida
  • Temozolodida [Spanish]
  • Temozolomide
  • Temozolomidum
  • Temozolomidum [Latin]
  • UNII-YF1K15M17Y

Systematic Names

  • 3,4-Dihydro-3-methyl-4-oxoimidazo(5,1-d)-as-tetrazine-8-carboxamide
  • Imidazo(5,1-d)(1,2,3,5)tetrazine-8-carboxamide, 3,4-dihydro-3-methyl-4-oxo-

Registry Numbers

CAS Registry Number

  • 85622-93-1

FDA UNII

  • YF1K15M17Y

System Generated Number

  • 0085622931

Structure Descriptors

InChI

1S/C6H6N6O2/c1-11-6(14)12-2-8-3(4(7)13)5(12)9-10-11/h2H,1H3,(H2,7,13)

InChIKey

BPEGJWRSRHCHSN-UHFFFAOYSA-N

Smiles

n1(nnc2n(c1=O)cnc2C(=O)N)C

Toxicity

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
mouse LDLo intraperitoneal 125mg/kg (125mg/kg)   Cancer Research. Vol. 47, Pg. 5846, 1987.