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Substance Name: Mirtazapine [USAN:USP:INN:BAN]
RN: 85650-52-8
UNII: A051Q2099Q
InChIKey: RONZAEMNMFQXRA-UHFFFAOYSA-N

Notes

  • Esmirtazapine is the maleate salt of the (S(+))-isomer.
  • NCI: A synthetic tetracyclic derivative of the piperazino-azepines with antidepressant activity. Although its mechanism of action is unknown, mirtazapine enhances central adrenergic and serotonergic transmission, possibly by acting as an antagonist at central presynaptic alpha 2 adrenergic inhibitory autoreceptors and heteroreceptors. This agent is a potent antagonist of 5-hydroxytryptamine type 2 (5-HT2), 5-HT3, and histamine 1 (H1) receptors, and a moderate anatgonist of peripheral alpha 1 adrenergic and muscarinic receptors.(NCI Thesaurus)

Molecular Formula

  • C17-H19-N3

Molecular Weight

  • 265.3581
 

Classification Codes

  • Adrenergic Agents
  • Adrenergic alpha-Antagonists
  • Adrenergic Antagonists
  • Antidepressant
  • Antidepressive Agents
  • Antidepressive Agents, Tricyclic
  • Central Nervous System Agents
  • Histamine Agents
  • Histamine Antagonists
  • Histamine H1 Antagonists
  • Neurotransmitter Agents
  • Psychotropic Drugs

Names and Synonyms

Name of Substance

  • Mirtazapine
  • Mirtazapine [USAN:USP:INN:BAN]

Synonyms

  • Avanza
  • EINECS 288-060-6
  • Mepirzapin
  • Mepirzepine
  • Mirtazapina
  • Mirtazapina [INN-Spanish]
  • Mirtazapine
  • Mirtazapinum
  • Mirtazapinum [INN-Latin]
  • Mirtazipine
  • Norset
  • Org 3770
  • Promyrtil
  • Remergil
  • Remergon
  • Remeron
  • Remeron SolTab
  • Rexer
  • Smilon
  • UNII-A051Q2099Q
  • Zispin

Systematic Names

  • (1)-1,2,3,4,10,14b-Hexahydro-2-methylpyrazino(2,1-a)pyrido(2,3-c)(2)benzazepine
  • Pyrazino(2,1-a)pyrido(2,3-c)(2)benzazepine, 1,2,3,4,10,14b-hexahydro-2-methyl-

Registry Numbers

CAS Registry Number

  • 85650-52-8

FDA UNII

  • A051Q2099Q

Other Registry Numbers

  • 61337-67-5
  • 82601-27-2

System Generated Number

  • 0085650528

Structure Descriptors

InChI

1S/C17H19N3/c1-19-9-10-20-16(12-19)15-7-3-2-5-13(15)11-14-6-4-8-18-17(14)20/h2-8,16H,9-12H2,1H3

InChIKey

RONZAEMNMFQXRA-UHFFFAOYSA-N

Smiles

CN1CCN2c3c(cccn3)Cc4ccccc4C2C1

Toxicity

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
man TDLo oral 1071ug/kg/I (1.071mg/kg) BEHAVIORAL: "HALLUCINATIONS, DISTORTED PERCEPTIONS"

BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)
Journal of Clinical Psychiatry. Vol. 59, Pg. 233, 1998.