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Substance Name: Cediranib maleate [USAN:JAN]
RN: 857036-77-2
UNII: 68AYS9A614
InChIKey: JRMGHBVACUJCRP-BTJKTKAUSA-N

Note

  • Indole-ether quinazoline; highly potent, orally bioavailable, vascular endothelial growth factor receptor-2 tyrosine kinase inhibitor for the treatment of cancer.

    NCI: The maleate salt of an indole ether quinazoline derivative with antineoplastic activities. Competing with adenosine triphosphate, cediranib binds to and inhibits all three vascular endothelial growth factor receptor (VEGFR-1,-2,-3) tyrosine kinases, thereby blocking VEGF-signaling, angiogenesis, and tumor cell growth. (NCI Thesaurus)

Molecular Formula

  • C25-H27-F-N4-O3.C4-H4-O4

Molecular Weight

  • 566.5829
 

Classification Codes

  • Antineoplastic Agents
  • Enzyme Inhibitors
  • Protein Kinase Inhibitors
  • Treatment of Cancer
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Names and Synonyms

Name of Substance

  • Cediranib maleate [USAN:JAN]

Synonyms

  • 4-((4-Fluoro-2-methyl-1H-indol-5-yl)oxy)-6-methoxy-7-(3-(pyrrolidin-1-yl)propoxy)quinazoline (2Z)-but-2-enedioate
  • AZD2171 maleate
  • Cediranib maleate
  • Recentin
  • UNII-68AYS9A614

Systematic Name

  • Quinazoline, 4-((4-fluoro-2-methyl-1H-indol-5-yl)oxy)-6-methoxy-7-(3-(1-pyrrolidinyl)propoxy)-, (2Z)-2-butenedioate (1:1)

Registry Numbers

CAS Registry Number

  • 857036-77-2

FDA UNII

  • 68AYS9A614

System Generated Number

  • 0857036772

Structure Descriptors

InChI

1S/C25H27FN4O3.C4H4O4/c1-16-12-17-19(29-16)6-7-21(24(17)26)33-25-18-13-22(31-2)23(14-20(18)27-15-28-25)32-11-5-10-30-8-3-4-9-30;5-3(6)1-2-4(7)8/h6-7,12-15,29H,3-5,8-11H2,1-2H3;1-2H,(H,5,6)(H,7,8)/b;2-1-

InChIKey

JRMGHBVACUJCRP-BTJKTKAUSA-N

Smiles

Cc1cc2c([nH]1)ccc(c2F)Oc3c4cc(c(cc4ncn3)OCCCN5CCCC5)OC.C(=C\C(=O)O)\C(=O)O