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Substance Name: Lenvatinib mesylate [USAN]
RN: 857890-39-2
UNII: 3J78384F61
InChIKey: HWLFIUUAYLEFCT-UHFFFAOYSA-N
Note
- A protein kinase inhibitor.
NCI: A synthetic, orally available inhibitor of vascular endothelial growth factor receptor 2 (VEGFR2, also known as KDR/FLK-1) tyrosine kinase with potential antineoplastic activity. Lenvatinib mesylate blocks VEGFR2 activation by VEGF, resulting in inhibition of the VEGF receptor signal transduction pathway, decreased vascular endothelial cell migration and proliferation, and vascular endothelial cell apoptosis. Check for active clinical trials or closed clinical trials using this agent. (NCI Thesaurus)
Molecular Formula
- C21-H19-Cl-N4-O4.C-H4-O3-S
Molecular Weight
- 522.9637
Classification Codes
- Antineoplastic
- Antineoplastic Agents
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Names and Synonyms
Name of Substance
- Lenvatinib mesylate [USAN]
Synonyms
- E7080
- Lenvatinib mesylate
- Lenvima
- N-(4-((6-Carbamoyl-7-methoxyquinolin-4-yl)oxy)-2-chlorophenyl)-N'-cyclopropylurea monomethanesulfonate
- UNII-3J78384F61
Systematic Name
- 6-Quinolinecarboxamide, 4-(3-chloro-4-(((cyclopropylamino)carbonyl)amino)phenoxy)- 7-methoxy-, methanesulfonate (1:1)
Registry Numbers
CAS Registry Number
- 857890-39-2
FDA UNII
- 3J78384F61
System Generated Number
- 0857890392