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Substance Name: Lenvatinib mesylate [USAN]
RN: 857890-39-2
UNII: 3J78384F61
InChIKey: HWLFIUUAYLEFCT-UHFFFAOYSA-N

Note

  • A protein kinase inhibitor.

    NCI: A synthetic, orally available inhibitor of vascular endothelial growth factor receptor 2 (VEGFR2, also known as KDR/FLK-1) tyrosine kinase with potential antineoplastic activity. Lenvatinib mesylate blocks VEGFR2 activation by VEGF, resulting in inhibition of the VEGF receptor signal transduction pathway, decreased vascular endothelial cell migration and proliferation, and vascular endothelial cell apoptosis. Check for active clinical trials or closed clinical trials using this agent. (NCI Thesaurus)

Molecular Formula

  • C21-H19-Cl-N4-O4.C-H4-O3-S

Molecular Weight

  • 522.9637
 

Classification Codes

  • Antineoplastic
  • Antineoplastic Agents
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Names and Synonyms

Name of Substance

  • Lenvatinib mesylate [USAN]

Synonyms

  • E7080
  • Lenvatinib mesylate
  • Lenvima
  • N-(4-((6-Carbamoyl-7-methoxyquinolin-4-yl)oxy)-2-chlorophenyl)-N'-cyclopropylurea monomethanesulfonate
  • UNII-3J78384F61

Systematic Name

  • 6-Quinolinecarboxamide, 4-(3-chloro-4-(((cyclopropylamino)carbonyl)amino)phenoxy)- 7-methoxy-, methanesulfonate (1:1)

Registry Numbers

CAS Registry Number

  • 857890-39-2

FDA UNII

  • 3J78384F61

System Generated Number

  • 0857890392

Structure Descriptors

InChI

InChI=1S/C21H19ClN4O4.CH4O3S/c1-29-19-10-17-13(9-14(19)20(23)27)18(6-7-24-17)30-12-4-5-16(15(22)8-12)26-21(28)25-11-2-3-11;1-5(2,3)4/h4-11H,2-3H2,1H3,(H2,23,27)(H2,25,26,28);1H3,(H,2,3,4)

InChIKey

HWLFIUUAYLEFCT-UHFFFAOYSA-N

Smiles

COc1cc2nccc(Oc3ccc(NC(=O)NC4CC4)c(Cl)c3)c2cc1C(=O)N.CS(=O)(=O)O