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Substance Name: Indometacin farnesil [JAN]
RN: 85801-02-1
UNII: MB2386WGG8
InChIKey: CFIGYZZVJNJVDQ-LMJOQDENSA-N

Classification Codes

  • Anti-Inflammatory Agents
  • Drug / Therapeutic Agent
  • Reproductive Effect

Molecular Formula

  • C34-H40-Cl-N-O4

Molecular Weight

  • 562.146
 
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Names and Synonyms

Name of Substance

  • Indometacin farnesil [JAN]
  • Indomethacin farnesil

Synonyms

  • 3,7,11-Trimethyl-2,6,10-dodecatrienyl 1-(4-chlorobenzoyl)-5-methoxy-2-methyl-1H-indole-3-acetate
  • E 0710
  • IMF
  • Indometacin farnesil
  • Indomethacin farnesil
  • Infree
  • UNII-MB2386WGG8

Systematic Name

  • 1H-Indole-3-acetic acid, 1-(4-chlorobenzoyl)-5-methoxy-2-methyl-, 3,7,11-trimethyl-2,6,10-dodecatrienyl ester

Registry Numbers

CAS Registry Number

  • 85801-02-1

FDA UNII

  • MB2386WGG8

System Generated Number

  • 0085801021

Structure Descriptors

InChI

1S/C34H40ClNO4/c1-23(2)9-7-10-24(3)11-8-12-25(4)19-20-40-33(37)22-30-26(5)36(32-18-17-29(39-6)21-31(30)32)34(38)27-13-15-28(35)16-14-27/h9,11,13-19,21H,7-8,10,12,20,22H2,1-6H3/b24-11+,25-19+

InChIKey

CFIGYZZVJNJVDQ-LMJOQDENSA-N

Smiles

Cc1c(c2cc(ccc2n1C(=O)c3ccc(cc3)Cl)OC)CC(=O)OC/C=C(\C)/CC/C=C(\C)/CCC=C(C)C

Toxicity

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
dog LD50 oral > 3gm/kg (3000mg/kg) GASTROINTESTINAL: "HYPERMOTILITY, DIARRHEA"

GASTROINTESTINAL: NAUSEA OR VOMITING
Yakuri to Chiryo. Pharmacology and Therapeutics. Vol. 17, Pg. 9, 1989.
mouse LD50 intramuscular > 4gm/kg (4000mg/kg)   Yakuri to Chiryo. Pharmacology and Therapeutics. Vol. 17, Pg. 9, 1989.
mouse LD50 intraperitoneal 1305mg/kg (1305mg/kg) BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)

SKIN AND APPENDAGES (SKIN): HAIR: OTHER
Yakuri to Chiryo. Pharmacology and Therapeutics. Vol. 17, Pg. 9, 1989.
mouse LD50 oral 6800mg/kg (6800mg/kg) SKIN AND APPENDAGES (SKIN): HAIR: OTHER

BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)
Yakuri to Chiryo. Pharmacology and Therapeutics. Vol. 17, Pg. 9, 1989.
mouse LD50 subcutaneous > 8gm/kg (8000mg/kg) BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)

SKIN AND APPENDAGES (SKIN): HAIR: OTHER
Yakuri to Chiryo. Pharmacology and Therapeutics. Vol. 17, Pg. 9, 1989.
rat LD50 intramuscular 2gm/kg (2000mg/kg) GASTROINTESTINAL: "HYPERMOTILITY, DIARRHEA" Yakuri to Chiryo. Pharmacology and Therapeutics. Vol. 17, Pg. 9, 1989.
rat LD50 intraperitoneal 3800mg/kg (3800mg/kg) GASTROINTESTINAL: "HYPERMOTILITY, DIARRHEA" Yakuri to Chiryo. Pharmacology and Therapeutics. Vol. 17, Pg. 9, 1989.
rat LD50 oral 1680mg/kg (1680mg/kg) GASTROINTESTINAL: "HYPERMOTILITY, DIARRHEA" Yakuri to Chiryo. Pharmacology and Therapeutics. Vol. 17, Pg. 9, 1989.
rat LD50 subcutaneous 2400mg/kg (2400mg/kg) GASTROINTESTINAL: "HYPERMOTILITY, DIARRHEA" Yakuri to Chiryo. Pharmacology and Therapeutics. Vol. 17, Pg. 9, 1989.