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Substance Name: Cilastatin sodium mixture with Imipenem
RN: 85960-17-4
InChIKey: VEVHCKVFLWYWCN-KJWPAVRRSA-M

Classification Code

  • Drug / Therapeutic Agent

Molecular Formula

  • C16-H25-N2-O5-S.C12-H17-N3-O4-S.Na

Molecular Weight

  • 679.7878
 
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Names and Synonyms

Results Name

  • Cilastatin sodium mixture with Imipenem

Name of Substance

  • Imipenem combination with cilastatin sodium

Synonyms

  • Cilastatin sodium mixture with Imipenem
  • Imipenem-cilastatin sodium mixt.
  • MK-0787 / MK-0791 (1:1)
  • Tienam
  • Zienam

Systematic Name

  • 1-Azabicyclo(3.2.0)hept-2-ene-2-carboxylic acid, 6-(1-hydroxyethyl)-3-((2-((iminomethyl)amino)ethyl)amino)-7-oxo-, (5R-(5-alpha,6-alpha(R*)))-, mixt. with (R-(R*,S*-(Z)))-7-((2-amino-2-carboxyethyl)thio)-2-(((2,2-dimethylcyclopropyl)carbonyl)amino)-2-heptenoic acid monosodium salt

Registry Numbers

CAS Registry Number

  • 85960-17-4

Related Registry Number

  • 92309-29-0 (Parent)

System Generated Number

  • 0085960174

Molecular Formulas

Molecular Formula

  • C16-H25-N2-O5-S.C12-H17-N3-O4-S.Na

Molecular Formula Fragments

  • C12-H17-N3-O4-S
  • C16-H25-N2-O5-S
  • COMPONENT
  • Na

Structure Descriptors

InChI

1S/C16H26N2O5S.C12H17N3O4S.Na/c1-16(2)8-10(16)13(19)18-12(15(22)23)6-4-3-5-7-24-9-11(17)14(20)21;1-6(16)9-7-4-8(20-3-2-14-5-13)10(12(18)19)15(7)11(9)17;/h6,10-11H,3-5,7-9,17H2,1-2H3,(H,18,19)(H,20,21)(H,22,23);5-7,9,16H,2-4H2,1H3,(H2,13,14)(H,18,19);/q;;+1/p-1/b12-6-;;/t10-,11+;6-,7-,9-;/m11./s1

InChIKey

VEVHCKVFLWYWCN-KJWPAVRRSA-M

Smiles

[Na+].C[C@@H](O)[C@@H]1[C@H]2CC(=C(N2C1=O)C(=O)O)SCCNC=N.CC3(C)C[C@@H]3C(=O)N\C(=C/CCCCSC[C@H](N)C(=O)O)\C(=O)[O-]

Toxicity

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
mouse LD50 intravenous 1068mg/kg (1068mg/kg)   Drugs in Japan Vol. -, Pg. 134, 1990.
mouse LD50 oral > 5gm/kg (5000mg/kg)   Drugs in Japan Vol. -, Pg. 134, 1990.
mouse LD50 subcutaneous 1922mg/kg (1922mg/kg)   Drugs in Japan Vol. -, Pg. 134, 1990.
rat LD50 intravenous > 1316mg/kg (1316mg/kg)   Drugs in Japan Vol. -, Pg. 134, 1990.
rat LD50 oral > 5gm/kg (5000mg/kg)   Drugs in Japan Vol. -, Pg. 134, 1990.
rat LD50 subcutaneous 2gm/kg (2000mg/kg)   Drugs in Japan Vol. -, Pg. 134, 1990.