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Substance Name: Benzatropine [INN:BAN]
RN: 86-13-5
UNII: 1NHL2J4X8K
InChIKey: GIJXKZJWITVLHI-PMOLBWCYSA-N

Note

  • A centrally active muscarinic antagonist that has been used in the symptomatic treatment of PARKINSON DISEASE. Benztropine also inhibits the uptake of dopamine.

Molecular Formula

  • C21-H25-N-O

Molecular Weight

  • 307.4345
 

Classification Codes

  • Anti-Dyskinesia Agents
  • Antiparkinson Agents
  • Autonomic Agents
  • Central Nervous System Agents
  • Cholinergic Agents
  • Cholinergic Antagonists
  • Dopamine Agents
  • Dopamine Uptake Inhibitors
  • Drug / Therapeutic Agent
  • Membrane Transport Modulators
  • Muscarinic Antagonists
  • Neurotransmitter Agents
  • Neurotransmitter Uptake Inhibitors
  • Parasympatholytics
  • Peripheral Nervous System Agents

Names and Synonyms

Results Name

  • Benzatropine [INN:BAN]

Name of Substance

  • Benzatropine [INN:BAN]
  • Benztropine

MeSH Heading

  • Benztropine

Synonyms

  • 1alphaH,5alphaH-tropane, 3alpha-(diphenylmethoxy)-
  • 8-Azabicyclo(3.2.1)octane, 3-(diphenylmethoxy)-8-methyl-, endo-
  • Akitan
  • Benzatropina
  • Benzatropina [INN-Spanish]
  • Benzatropine
  • Benzatropinum
  • Benzatropinum [INN-Latin]
  • Benztropine
  • Benztropinum
  • Cobrentin
  • Cogentine
  • Cogentinol
  • HSDB 3014
  • NK 02
  • Tropine benzohydryl ether
  • UNII-1NHL2J4X8K

Systematic Names

  • 1-alpha-H,5-alpha-H-Tropane, 3-alpha-(diphenylmethoxy)-
  • 8-Azabicyclo(3.2.1)octane, 3-(diphenylmethoxy)-8-methyl-, endo- (9CI)

Registry Numbers

CAS Registry Number

  • 86-13-5

FDA UNII

  • 1NHL2J4X8K

System Generated Number

  • 0000086135

Structure Descriptors

InChI

1S/C21H25NO/c1-22-18-12-13-19(22)15-20(14-18)23-21(16-8-4-2-5-9-16)17-10-6-3-7-11-17/h2-11,18-21H,12-15H2,1H3/t18-,19+,20+

InChIKey

GIJXKZJWITVLHI-PMOLBWCYSA-N

Smiles

CN1[C@@H]2CC[C@H]1C[C@H](C2)OC(c3ccccc3)c4ccccc4

Toxicity

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
mouse LD50 intravenous 25mg/kg (25mg/kg) BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD

SENSE ORGANS AND SPECIAL SENSES: MYDRIASIS (PUPILLARY DILATION): EYE

LUNGS, THORAX, OR RESPIRATION: OTHER CHANGES
Journal of Medicinal and Pharmaceutical Chemistry. Vol. 4, Pg. 215, 1961.
mouse LD50 subcutaneous 60mg/kg (60mg/kg) BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD

SENSE ORGANS AND SPECIAL SENSES: MYDRIASIS (PUPILLARY DILATION): EYE

LUNGS, THORAX, OR RESPIRATION: OTHER CHANGES
Journal of Medicinal and Pharmaceutical Chemistry. Vol. 4, Pg. 215, 1961.