Skip Navigation
ChemIDplus A TOXNET DATABASE LiteBrowseAdvanced

Substance Name: Hydralazine [INN:BAN]
RN: 86-54-4
UNII: 26NAK24LS8
InChIKey: RPTUSVTUFVMDQK-UHFFFAOYSA-N

Note

  • A direct-acting vasodilator that is used as an antihypertensive agent.

Molecular Formula

  • C8-H8-N4

Molecular Weight

  • 160.179
 

Classification Codes

Classification Codes

  • Antihypertensive Agents
  • Cardiovascular Agents
  • Drug / Therapeutic Agent
  • Human Data
  • Mutation Data
  • Reproductive Effect
  • Tumor Data
  • Vasodilator Agents

Superlist Classification Code

  • Overall Carcinogenic Evaluation: Group 3

Names and Synonyms

Results Name

  • Hydralazine [INN:BAN]

Name of Substance

  • Hydralazine
  • Hydralazine [INN:BAN]

MeSH Heading

  • Hydralazine

Synonyms

  • 1(2H)-Phthalazinone hydrazone
  • 1-Hydrazinophthalazine
  • 1-Phthalazinylhydrazine
  • 5-25-17-00412 (Beilstein Handbook Reference)
  • 6-Hydralazine
  • Apresolin
  • Apressin
  • Apressin (pharmaceutical)
  • Aprezolin
  • BA 5968
  • BRN 0132615
  • C 5968
  • C-5968
  • CCRIS 5385
  • Ciba 5968
  • EINECS 201-680-3
  • Hidralazin
  • Hidralazina
  • Hidralazina [INN-Spanish]
  • Hidralazina [Spanish]
  • Hipoftalin
  • Hydralazin
  • Hydralazine
  • Hydralazinum
  • Hydralazinum [INN-Latin]
  • Hydrazinophthalazine
  • Hydrazone 1(2H)-phthalazinone
  • Hypophthalin
  • Idralazina
  • Idralazina [DCIT]
  • Idralazina [Italian]
  • NSC 126699
  • Praparat 5968
  • UNII-26NAK24LS8

Systematic Names

  • 1(2H)-Phthalazinone, hydrazone
  • Hydralazine
  • Phthalazine, 1-hydrazino-

Superlist Name

  • Hydralazine

Registry Numbers

CAS Registry Number

  • 86-54-4

FDA UNII

  • 26NAK24LS8

Related Registry Number

  • 304-20-1 (mono-hydrochloride)

System Generated Number

  • 0000086544

Structure Descriptors

InChI

1S/C8H8N4/c9-11-8-7-4-2-1-3-6(7)5-10-12-8/h1-5H,9H2,(H,11,12)

InChIKey

RPTUSVTUFVMDQK-UHFFFAOYSA-N

Smiles

c\12c(cn[nH]c1=N/N)cccc2

Toxicity

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
dog LD50 intravenous 50mg/kg (50mg/kg)   Arzneimittel-Forschung. Drug Research. Vol. 35, Pg. 818, 1985.
dog LD50 oral 100mg/kg (100mg/kg)   Arzneimittel-Forschung. Drug Research. Vol. 23, Pg. 1591, 1973.
guinea pig LD50 oral 250mg/kg (250mg/kg)   Bollettino Chimico Farmaceutico. Vol. 111, Pg. 480, 1972.
man TDLo intramuscular 89ug/kg (0.089mg/kg) CARDIAC: CARDIOMYOPATHY INCLUDING INFARCTION

CARDIAC: CHANGES IN CORONARY ARTERIES
European Journal of Pediatrics. Vol. 145, Pg. 318, 1986.
man TDLo oral 2086mg/kg/2Y- (2086mg/kg) SKIN AND APPENDAGES (SKIN): "DERMATITIS, ALLERGIC: AFTER SYSTEMIC EXPOSURE" British Medical Journal. Vol. 289, Pg. 410, 1984.
mouse LD50 intraperitoneal 80mg/kg (80mg/kg)   Pharmaceutical Chemistry Journal Vol. 30, Pg. 22, 1996.
mouse LD50 intravenous 52mg/kg (52mg/kg)   Medicamentos de Actualidad. Vol. 12, Pg. 468, 1976.
mouse LD50 oral 122mg/kg (122mg/kg)   Pharmacological Research Communications. Vol. 8, Pg. 295, 1976.
mouse LD50 subcutaneous 150mg/kg (150mg/kg)   Russian Pharmacology and Toxicology Vol. 31, Pg. 53, 1968.
rabbit LD50 oral 300mg/kg (300mg/kg)   Arzneimittel-Forschung. Drug Research. Vol. 23, Pg. 1591, 1973.
rat LD50 intraperitoneal 25mg/kg (25mg/kg)   Journal of Pharmacology and Experimental Therapeutics. Vol. 143, Pg. 7, 1964.
rat LD50 intravenous 34mg/kg (34mg/kg) BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)

GASTROINTESTINAL: NAUSEA OR VOMITING

CARDIAC: CHANGE IN RATE
Journal of the American Pharmaceutical Association, Scientific Edition. Vol. 40, Pg. 559, 1951.
rat LD50 oral 90mg/kg (90mg/kg) CARDIAC: PULSE RATE INCREASE WITHOUT FALL IN BP

VASCULAR: BP LOWERING NOT CHARACTERIZED IN AUTONOMIC SECTION
Pharmacological Research Communications. Vol. 8, Pg. 295, 1976.
women TDLo oral 730mg/kg/2Y-I (730mg/kg) SKIN AND APPENDAGES (SKIN): "DERMATITIS, ALLERGIC: AFTER SYSTEMIC EXPOSURE" British Medical Journal. Vol. 289, Pg. 410, 1984.

Physical Properties

Physical Property Value Units Temp (deg C) Source
Melting Point 172-173 deg C   EXP
log P (octanol-water) 1 (none)   EXP
Water Solubility 9560 mg/L 25 EST
Vapor Pressure 7.47E-06 mm Hg 25 EST
Henry's Law Constant 4.14E-13 atm-m3/mole 25 EST
Atmospheric OH Rate Constant 4.38E-11 cm3/molecule-sec 25 EST

Physical property data is provided to ChemIDplus by SRC, Inc.