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Substance Name: Hydralazine [INN:BAN]
RN: 86-54-4
UNII: 26NAK24LS8
InChIKey: RPTUSVTUFVMDQK-UHFFFAOYSA-N
Note
- A direct-acting vasodilator that is used as an antihypertensive agent.
Molecular Formula
- C8-H8-N4
Molecular Weight
- 160.179
- All
- Classifications
- Links to Resources
- Names & Synonyms
- Registry Numbers
- Structure Descriptors
- Toxicity
- Physical Properties
Classification Codes
Classification Codes
- Antihypertensive Agents
- Cardiovascular Agents
- Drug / Therapeutic Agent
- Human Data
- Mutation Data
- Reproductive Effect
- Tumor Data
- Vasodilator Agents
Superlist Classification Code
- Overall Carcinogenic Evaluation: Group 3
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Names and Synonyms
Results Name
- Hydralazine [INN:BAN]
Name of Substance
- Hydralazine
- Hydralazine [INN:BAN]
MeSH Heading
- Hydralazine
Synonyms
- 1(2H)-Phthalazinone hydrazone
- 1-Hydrazinophthalazine
- 1-Phthalazinylhydrazine
- 5-25-17-00412 (Beilstein Handbook Reference)
- 6-Hydralazine
- Apresolin
- Apressin
- Apressin (pharmaceutical)
- Aprezolin
- BA 5968
- BRN 0132615
- C 5968
- C-5968
- CCRIS 5385
- Ciba 5968
- EINECS 201-680-3
- Hidralazin
- Hidralazina
- Hidralazina [INN-Spanish]
- Hidralazina [Spanish]
- Hipoftalin
- Hydralazin
- Hydralazine
- Hydralazinum
- Hydralazinum [INN-Latin]
- Hydrazinophthalazine
- Hydrazone 1(2H)-phthalazinone
- Hypophthalin
- Idralazina
- Idralazina [DCIT]
- Idralazina [Italian]
- NSC 126699
- Praparat 5968
- UNII-26NAK24LS8
Systematic Names
- 1(2H)-Phthalazinone, hydrazone
- Hydralazine
- Phthalazine, 1-hydrazino-
Superlist Name
- Hydralazine
Registry Numbers
CAS Registry Number
- 86-54-4
FDA UNII
- 26NAK24LS8
Related Registry Number
- 304-20-1 (mono-hydrochloride)
System Generated Number
- 0000086544
Structure Descriptors
InChI
1S/C8H8N4/c9-11-8-7-4-2-1-3-6(7)5-10-12-8/h1-5H,9H2,(H,11,12)InChIKey
RPTUSVTUFVMDQK-UHFFFAOYSA-NSmiles
c\12c(cn[nH]c1=N/N)Toxicity
| Organism | Test Type | Route | Reported Dose (Normalized Dose) | Effect | Source |
|---|---|---|---|---|---|
| dog | LD50 | intravenous | 50mg/kg (50mg/kg) | Arzneimittel-Forschung. Drug Research. Vol. 35, Pg. 818, 1985. | |
| dog | LD50 | oral | 100mg/kg (100mg/kg) | Arzneimittel-Forschung. Drug Research. Vol. 23, Pg. 1591, 1973. | |
| guinea pig | LD50 | oral | 250mg/kg (250mg/kg) | Bollettino Chimico Farmaceutico. Vol. 111, Pg. 480, 1972. | |
| man | TDLo | intramuscular | 89ug/kg (0.089mg/kg) | CARDIAC: CARDIOMYOPATHY INCLUDING INFARCTION CARDIAC: CHANGES IN CORONARY ARTERIES | European Journal of Pediatrics. Vol. 145, Pg. 318, 1986. |
| man | TDLo | oral | 2086mg/kg/2Y- (2086mg/kg) | SKIN AND APPENDAGES (SKIN): "DERMATITIS, ALLERGIC: AFTER SYSTEMIC EXPOSURE" | British Medical Journal. Vol. 289, Pg. 410, 1984. |
| mouse | LD50 | intraperitoneal | 80mg/kg (80mg/kg) | Pharmaceutical Chemistry Journal Vol. 30, Pg. 22, 1996. | |
| mouse | LD50 | intravenous | 52mg/kg (52mg/kg) | Medicamentos de Actualidad. Vol. 12, Pg. 468, 1976. | |
| mouse | LD50 | oral | 122mg/kg (122mg/kg) | Pharmacological Research Communications. Vol. 8, Pg. 295, 1976. | |
| mouse | LD50 | subcutaneous | 150mg/kg (150mg/kg) | Russian Pharmacology and Toxicology Vol. 31, Pg. 53, 1968. | |
| rabbit | LD50 | oral | 300mg/kg (300mg/kg) | Arzneimittel-Forschung. Drug Research. Vol. 23, Pg. 1591, 1973. | |
| rat | LD50 | intraperitoneal | 25mg/kg (25mg/kg) | Journal of Pharmacology and Experimental Therapeutics. Vol. 143, Pg. 7, 1964. | |
| rat | LD50 | intravenous | 34mg/kg (34mg/kg) | BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY) CARDIAC: CHANGE IN RATE GASTROINTESTINAL: NAUSEA OR VOMITING | Journal of the American Pharmaceutical Association, Scientific Edition. Vol. 40, Pg. 559, 1951. |
| rat | LD50 | oral | 90mg/kg (90mg/kg) | CARDIAC: PULSE RATE INCREASE WITHOUT FALL IN BP VASCULAR: BP LOWERING NOT CHARACTERIZED IN AUTONOMIC SECTION | Pharmacological Research Communications. Vol. 8, Pg. 295, 1976. |
| women | TDLo | oral | 730mg/kg/2Y-I (730mg/kg) | SKIN AND APPENDAGES (SKIN): "DERMATITIS, ALLERGIC: AFTER SYSTEMIC EXPOSURE" | British Medical Journal. Vol. 289, Pg. 410, 1984. |
Physical Properties
| Physical Property | Value | Units | Temp (deg C) | Source |
|---|---|---|---|---|
| Melting Point | 172-173 | deg C | EXP | |
| log P (octanol-water) | 1 | (none) | EXP | |
| Water Solubility | 9560 | mg/L | 25 | EST |
| Vapor Pressure | 7.47E-06 | mm Hg | 25 | EST |
| Henry's Law Constant | 4.14E-13 | atm-m3/mole | 25 | EST |
| Atmospheric OH Rate Constant | 4.38E-11 | cm3/molecule-sec | 25 | EST |
Physical property data is provided to ChemIDplus by SRC, Inc.