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Substance Name: Gadopentetate dimeglumine [USAN:USP]
RN: 86050-77-3
UNII: RH248G8V27
InChIKey: LGMLJQFQKXPRGA-VPVMAENOSA-K

Note

  • A complex of gadolinium with a chelating agent, diethylenetriamine penta-acetic acid (DTPA see PENTETIC ACID), that is given to enhance the image in cranial and spinal MRIs. (From Martindale, The Extra Pharmacopoeia, 30th ed, p706)

Molecular Formula

  • C14-H20-Gd-N3-O10.2C7-H17-N-O5

Molecular Weight

  • 941.0233
 

Classification Code

  • Diagnostic Aid

Names and Synonyms

Name of Substance

  • Gadolinium DTPA
  • Gadopentetate dimeglumine [USAN:USP]

MeSH Heading

  • Gadolinium DTPA

Synonyms

  • BAY 86-4882
  • BAY86-4882
  • Diethylenetriaminepentaacetic acid dimeglumine salt gadolinium chelate
  • Dihydrogen (N,N-bis(2-(bis(carboxymethyl)amino)ethyl)glycinato(5-))gadolinate(2-), compound with 1-deoxy-1-(methylamino)-D-glucitol (1:2)
  • Dimeglumine-gadolinium-dtpa
  • Gadolinate(2-), (N,N-bis(2-(bis(carboxymethyl)amino)ethyl)glycinato(5-))-, dihydrogen, compd. with 1-deoxy-1-(methylamino)-D-glucitol (1:2)
  • Gadolinium-DTPA-dimeglumine
  • Gadopentetate dimeglumine
  • Gadopentetate meglumine
  • Gadopentetic acid dimeglumine salt
  • Gd-DTPA
  • HSDB 7548
  • Magnevist
  • Meglumine gadopentetate
  • SH L 451 A
  • SHL 451A
  • UNII-RH248G8V27
  • ZK 93035

Systematic Name

  • Gadolinate(2-), (N,N-bis(2-(bis(carboxymethyl)amino)ethyl)glycinato(5-))-, dihydrogen, compd. with 1-deoxy-1-(methylamino)-D-glucitol (1:2)

Registry Numbers

CAS Registry Number

  • 86050-77-3

FDA UNII

  • RH248G8V27

Related Registry Number

  • 80529-93-7 (Parent)

System Generated Number

  • 0086050773

Molecular Formulas

Molecular Formula

  • C14-H20-Gd-N3-O10.2C7-H17-N-O5

Molecular Formula Fragments

  • C14-H20-Gd-N3-O10
  • C7-H17-N-O5
  • COMPONENT

Structure Descriptors

InChI

1S/C14H23N3O10.2C7H17NO5.Gd/c18-10(19)5-15(1-3-16(6-11(20)21)7-12(22)23)2-4-17(8-13(24)25)9-14(26)27;2*1-8-2-4(10)6(12)7(13)5(11)3-9;/h1-9H2,(H,18,19)(H,20,21)(H,22,23)(H,24,25)(H,26,27);2*4-13H,2-3H2,1H3;/q;;;+3/p-3/t;2*4-,5+,6+,7+;/m.00./s1

InChIKey

LGMLJQFQKXPRGA-VPVMAENOSA-K

Smiles

[H+].[H+].CNC[C@@H]([C@H]([C@@H]([C@@H](CO)O)O)O)O.CNC[C@@H]([C@H]([C@@H]([C@@H](CO)O)O)O)O.C1CN23CC(=O)[O-][Gd+3]24567(N1(CCN4(CC(=O)[O-]5)CC(=O)[O-]6)CC(=O)[O-]7)[O-]C(=O)C3

Toxicity

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
mouse LDLo intravenous 4291mg/kg (4291mg/kg) BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD Toxicology Letters. Vol. (Suppl), Pg. 254, 1992.
rat LD50 intravenous 9411mg/kg (9411mg/kg)   AJR, American Journal of Roentgenology. Vol. 142, Pg. 619, 1984.
rat LD50 parenteral 612gm/kg (612000mg/kg)   AJR, American Journal of Roentgenology. Vol. 142, Pg. 619, 1984.