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Substance Name: Angiostatin
RN: 86090-08-6

Notes

  • A 38-kDa-fragment of plasminogen
  • Circulating 38-kDa proteins that are internal peptide fragments of PLASMINOGEN. The name derives from the fact that they are potent ANGIOGENESIS INHIBITORS. Angiostatins contain four KRINGLE DOMAINS which are associated with their potent angiostatic activity.

Molecular Formula

  • Unspecified
 

Classification Codes

  • Angiogenesis Inhibitors
  • Angiogenesis Modulating Agents
  • Antineoplastic Agents
  • Drug / Therapeutic Agent
  • Growth Inhibitors
  • Growth Substances
  • Hypotensive Agent
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Names and Synonyms

MeSH Heading

  • Angiostatins

Systematic Name

  • Angiostatin

Registry Numbers

CAS Registry Number

  • 86090-08-6

System Generated Number

  • 0086090086

Toxicity

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
mouse LD intravenous > 1gm/kg (1000mg/kg)   Japanese Kokai Tokyo Koho Patents. Vol. #83-36391,