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Substance Name: Tolufazepam [INN]
RN: 86273-92-9
UNII: 98SR74X50D
InChIKey: FFZOBTGTWSRRMB-UHFFFAOYSA-N

Classification Code

  • Drug / Therapeutic Agent

Molecular Formula

  • C24-H20-Cl2-N2-O3-S

Molecular Weight

  • 487.405
 
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Names and Synonyms

Name of Substance

  • Tolufazepam [INN]

Synonyms

  • 1-(4'-Methylphenylsulfonyl)ethyl-5-(2-chlorophenyl)-7-chloro-2H-1,4-benzodiazepin-2-one
  • 7-Chloro-5-(o-chlorophenyl)-1,3-dihydro-1-(2-(p-tolylsulfonyl)ethyl)-2H-1,4-benzodiazepin-2-one
  • Inn Tolufazepam
  • Tolufazepam
  • Tolufazepamum
  • Tolufazepamum [Latin]
  • UNII-98SR74X50D

Systematic Names

  • 2H-1,4-Benzodiazepin-2-one, 1,3-dihydro-7-chloro-5-(2-chlorophenyl)-1-(2-((4-methylphenyl)sulfonyl)ethyl)-
  • 7-Chloro-5-(o-chlorophenyl)-1,3-dihydro-1-(2-(p-tolylsulfonyl)ethyl)-2H-1,4-benzodiazepin-2-one

Registry Numbers

CAS Registry Number

  • 86273-92-9

FDA UNII

  • 98SR74X50D

System Generated Number

  • 0086273929

Structure Descriptors

InChI

1S/C24H20Cl2N2O3S/c1-16-6-9-18(10-7-16)32(30,31)13-12-28-22-11-8-17(25)14-20(22)24(27-15-23(28)29)19-4-2-3-5-21(19)26/h2-11,14H,12-13,15H2,1H3

InChIKey

FFZOBTGTWSRRMB-UHFFFAOYSA-N

Smiles

Cc1ccc(cc1)S(=O)(=O)CCN2c3ccc(cc3C(=NCC2=O)c4ccccc4Cl)Cl

Toxicity

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
mouse LD50 oral 1350mg/kg (1350mg/kg) SENSE ORGANS AND SPECIAL SENSES: OTHER: EYE

BEHAVIORAL: CHANGES IN MOTOR ACTIVITY (SPECIFIC ASSAY)
Archives Internationales de Pharmacodynamie et de Therapie. Vol. 293, Pg. 57, 1988.