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Substance Name: Methylprednisolone aceponate [INN]
RN: 86401-95-8
UNII: ET54W9J4U2
InChIKey: DALKLAYLIPSCQL-YPYQNWSCSA-N

Classification Codes

  • Anti-Inflammatory Agents
  • Drug / Therapeutic Agent
  • Reproductive Effect
  • Skin / Eye Irritant

Molecular Formula

  • C27-H36-O7

Molecular Weight

  • 472.5744
 
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Names and Synonyms

Name of Substance

  • Methylprednisolone aceponate
  • Methylprednisolone aceponate [INN]

Synonyms

  • Aceponate de methylprednisolone
  • Aceponate de methylprednisolone [French]
  • Aceponato de metilprednisolona
  • Aceponato de metilprednisolona [Spanish]
  • Advantan
  • BRN 5663614
  • Methylprednisolone aceponate
  • Methylprednisoloni aceponas
  • Methylprednisoloni aceponas [Latin]
  • SH-440
  • UNII-ET54W9J4U2
  • ZK91588

Systematic Names

  • 11beta,17,21-Trihydroxy-6alpha-methylpregna-1,4-diene-3,20-dione, 21-acetate 17-propionate
  • Pregna-1,4-diene-3,20-dione, 21-(acetyloxy)-11-hydroxy-6-methyl-17-(1-oxopropoxy)-, (6-alpha,11-beta)-

Registry Numbers

CAS Registry Number

  • 86401-95-8

FDA UNII

  • ET54W9J4U2

System Generated Number

  • 0086401958

Structure Descriptors

InChI

1S/C27H36O7/c1-6-23(32)34-27(22(31)14-33-16(3)28)10-8-19-18-11-15(2)20-12-17(29)7-9-25(20,4)24(18)21(30)13-26(19,27)5/h7,9,12,15,18-19,21,24,30H,6,8,10-11,13-14H2,1-5H3/t15-,18-,19-,21-,24+,25-,26-,27-/m0/s1

InChIKey

DALKLAYLIPSCQL-YPYQNWSCSA-N

Smiles

CCC(=O)O[C@@]1(CC[C@H]2[C@@H]3C[C@H](C)C4=CC(=O)C=C[C@]4(C)[C@H]3[C@@H](O)C[C@]12C)C(=O)COC(=O)C

Toxicity

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
rat LD50 oral > 2gm/kg (2000mg/kg) GASTROINTESTINAL: "HYPERMOTILITY, DIARRHEA"

KIDNEY, URETER, AND BLADDER: INCONTINENCE
Yakuri to Chiryo. Pharmacology and Therapeutics. Vol. 19, Pg. 3015, 1991.
rat LD50 subcutaneous > 3gm/kg (3000mg/kg) ENDOCRINE: OTHER CHANGES Yakuri to Chiryo. Pharmacology and Therapeutics. Vol. 19, Pg. 3015, 1991.