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Substance Name: Clavulanic acid mixture with ticarcillin
RN: 86482-18-0
InChIKey: XWMVMWTVLSLJGY-FAJPTIRJSA-N

Note

  • Combination of ticarcillin and clavulanic acid; used against gram-negative rods.

Classification Codes

  • Anti-Bacterial Agents
  • Anti-Infective Agents
  • beta-Lactamase Inhibitors
  • Drug / Therapeutic Agent
  • Enzyme Inhibitors

Molecular Formula

  • C15-H16-N2-O6-S2.C8-H9-N-O5

Molecular Weight

  • 583.5925
 
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Names and Synonyms

Results Name

  • Clavulanic acid mixture with Ticarcillin

Name of Substance

  • Ticarcillin-clavulanic acid

Synonyms

  • BRL 28500
  • Clavulanic acid - ticarcillin mixt.
  • Clavulanic acid mixture with Ticarcillin
  • Ticarcillin - clavulanic acid mixt.
  • Ticarcillin disodium and clavulanate potassium
  • Ticarcillin-clavulanic acid
  • Ticarcillin-clavulanic acid mixt.
  • Timentin
  • Timentin in plastic container

Systematic Names

  • 4-Oxa-1-azabicyclo(3.2.0)heptane-2-carboxylic acid, 3-(2-hydroxyethylidene)-7-oxo-, (2R,3Z,5R)-, mixt. with (2S,5R,6R)-6-(((2R)-carboxy-3-thienylacetyl)amino)-3,3-dimethyl-7-oxo-4-thia-1-azabicyclo(3.2.0)heptane-2-carboxylic acid
  • 4-Oxa-1-azabicyclo(3.2.0)heptane-2-carboxylic acid, 3-(2-hydroxyethylidene)-7-oxo-, (2R-(2-alpha,3Z,5-alpha))-, mixt. with (2S-(2-alpha,5-alpha,6-beta(S*)))-6-((carboxy-3-thienylacetyl)amino)-3,3-dimethyl-7-oxo-4-thia-1-azabicyclo(3.2.0)heptane-2-carboxylic acid

Registry Numbers

CAS Registry Number

  • 86482-18-0

System Generated Number

  • 0086482180

Molecular Formulas

Molecular Formula

  • C15-H16-N2-O6-S2.C8-H9-N-O5

Molecular Formula Fragments

  • C15-H16-N2-O6-S2
  • C8-H9-N-O5
  • COMPONENT

Structure Descriptors

InChI

1S/C15H16N2O6S2.C8H9NO5/c1-15(2)9(14(22)23)17-11(19)8(12(17)25-15)16-10(18)7(13(20)21)6-3-4-24-5-6;10-2-1-4-7(8(12)13)9-5(11)3-6(9)14-4/h3-5,7-9,12H,1-2H3,(H,16,18)(H,20,21)(H,22,23);1,6-7,10H,2-3H2,(H,12,13)/b;4-1-/t7-,8-,9+,12-;6-,7-/m11/s1

InChIKey

XWMVMWTVLSLJGY-FAJPTIRJSA-N

Smiles

CC1([C@@H](N2[C@H](S1)[C@@H](C2=O)NC(=O)[C@@H](c3ccsc3)C(=O)O)C(=O)O)C.C1[C@@H]2N(C1=O)[C@H](/C(=C/CO)/O2)C(=O)O

Toxicity

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
mouse LD50 intramuscular > 2gm/kg (2000mg/kg) SKIN AND APPENDAGES (SKIN): "DERMATITIS, OTHER: AFTER SYSTEMIC EXPOSURE" Chemotherapy Vol. 34(Suppl,
mouse LD50 intravenous 3792mg/kg (3792mg/kg)   Chemotherapy Vol. 34(Suppl,
mouse LD50 intravenous 3792mg/kg (3792mg/kg) LUNGS, THORAX, OR RESPIRATION: DYSPNEA

BEHAVIORAL: ATAXIA
Chemotherapy Vol. 34(Suppl,
mouse LD50 oral 12635mg/kg (12635mg/kg)   Chemotherapy Vol. 34(Suppl,
mouse LD50 subcutaneous 7118mg/kg (7118mg/kg) SKIN AND APPENDAGES (SKIN): HAIR: OTHER Chemotherapy Vol. 34(Suppl,
rat LD50 intramuscular > 2gm/kg (2000mg/kg) SKIN AND APPENDAGES (SKIN): "DERMATITIS, OTHER: AFTER SYSTEMIC EXPOSURE" Chemotherapy Vol. 34(Suppl,
rat LD50 intravenous 4968mg/kg (4968mg/kg) LUNGS, THORAX, OR RESPIRATION: DYSPNEA

BEHAVIORAL: ATAXIA
Chemotherapy Vol. 34(Suppl,
rat LD50 oral 12990mg/kg (12990mg/kg) GASTROINTESTINAL: "HYPERMOTILITY, DIARRHEA" Chemotherapy Vol. 34(Suppl,
rat LD50 subcutaneous 7295mg/kg (7295mg/kg) SKIN AND APPENDAGES (SKIN): HAIR: OTHER Chemotherapy Vol. 34(Suppl,