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Substance Name: Methoserpidine [INN:BAN:DCF]
RN: 865-04-3
UNII: 8F8C1JQH53
InChIKey: ULBNWNUHGJLQHO-VKMIBBQISA-N

Classification Codes

  • Drug / Therapeutic Agent
  • Human Data
  • Tumor Data

Molecular Formula

  • C33-H40-N2-O9

Molecular Weight

  • 608.684
 
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Names and Synonyms

Name of Substance

  • Methoserpidine [INN:BAN:DCF]

Synonyms

  • 10-Methoxy-11-desmethoxyreserpine
  • 10-Methoxydeserpidine
  • Canescine 10-methoxyderivative
  • Decaserpil
  • Decaserpyl
  • Decaserpyl plus
  • Deserpidine, 10-methoxy-
  • EINECS 212-733-5
  • Methoserpidine
  • Methoserpidinum
  • Methoserpidinum [INN-Latin]
  • Metoserpidina
  • Metoserpidina [INN-Spanish]
  • Minoran
  • Neoserpin
  • NSC 169423
  • R 694
  • Resertene
  • Tenserpina
  • UNII-8F8C1JQH53

Systematic Names

  • 10-Methoxydeserpidine
  • 3-beta,20-alpha-Yohimban-16-beta-carboxylic acid, 18-beta-hydroxy-10,17-alpha-dimethoxy-, methyl ester, 3,4,5-trimethoxybenzoate (ester)
  • 3beta,20alpha-Yohimban-16beta-carboxylic acid, 18beta-hydroxy-10,17alpha-dimethoxy-, methyl ester, 3,4,5-trimethoxybenzoate (ester) (8CI)
  • Methoserpidine
  • Yohimban-16-carboxylic acid, 10,17-dimethoxy-18-((3,4,5-trimethoxybenzoyl)oxy)-, methyl ester, (3beta,16beta,17alpha,18beta,20alpha)- (9CI)

Registry Numbers

CAS Registry Number

  • 865-04-3

FDA UNII

  • 8F8C1JQH53

Other Registry Number

  • 794517-86-5

System Generated Number

  • 0000865043

Structure Descriptors

InChI

1S/C33H40N2O9/c1-38-19-7-8-23-22(14-19)20-9-10-35-16-18-13-27(44-32(36)17-11-25(39-2)30(41-4)26(12-17)40-3)31(42-5)28(33(37)43-6)21(18)15-24(35)29(20)34-23/h7-8,11-12,14,18,21,24,27-28,31,34H,9-10,13,15-16H2,1-6H3/t18-,21+,24-,27-,28+,31+/m1/s1

InChIKey

ULBNWNUHGJLQHO-VKMIBBQISA-N

Smiles

COc1ccc2c(c1)c3c([nH]2)[C@H]4C[C@H]5[C@H](C[C@H]([C@@H]([C@H]5C(=O)OC)OC)OC(=O)c6cc(c(c(c6)OC)OC)OC)CN4CC3

Toxicity

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
guinea pig LDLo intravenous 52mg/kg (52mg/kg)   Therapie. Vol. 15, Pg. 663, 1960.
mouse LD oral > 2gm/kg (2000mg/kg)   Archives Internationales de Pharmacodynamie et de Therapie. Vol. 124, Pg. 237, 1960.
mouse LD50 intraperitoneal 82mg/kg (82mg/kg)   Journal of Pharmacy and Pharmacology. Vol. 12, Pg. 677, 1960.
mouse LD50 intravenous 8750ug/kg (8.75mg/kg) GASTROINTESTINAL: "HYPERMOTILITY, DIARRHEA"

BEHAVIORAL: FOOD INTAKE (ANIMAL)

BEHAVIORAL: ALTERED SLEEP TIME (INCLUDING CHANGE IN RIGHTING REFLEX)
Arzneimittel-Forschung. Drug Research. Vol. 14, Pg. 1040, 1964.