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Substance Name: Vinblastine [INN:BAN]
RN: 865-21-4
UNII: 5V9KLZ54CY
InChIKey: JXLYSJRDGCGARV-CFWMRBGOSA-N
Note
- Antitumor alkaloid isolated from Vinca rosea. (Merck, 11th ed.)
Molecular Formula
- C46-H58-N4-O9
Molecular Weight
- 810.9832
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- Classifications
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- Names & Synonyms
- Registry Numbers
- Structure Descriptors
- Toxicity
- Physical Properties
Classification Codes
- Antimitotic Agents
- Antineoplastic Agents
- Antineoplastic Agents, Phytogenic
- Drug / Therapeutic Agent
- Human Data
- Mitosis Modulators
- Mutation Data
- Natural Product
- Reproductive Effect
- Tubulin Modulators
- Tumor Data
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Names and Synonyms
Name of Substance
- Vinblastine
- Vinblastine [INN:BAN]
MeSH Heading
- Vinblastine
Synonyms
- (3aR-(3aalpha,4beta,5beta,5abeta,9(3R*,5S*,7R*,9S*),10bR*,13aalpha))-methyl 4-(acetyloxy)-3a-ethyl-9-(5-ethyl-1,4,5,6,7,8,9,10-octahydro-5-hydroxy-9-(methoxycarbonyl)-2H-3,7-methanoazacycloundecino(5,4-b)indol-9-yl)-3a,4,5,5a,6,11,12,13a-octahydro-5-hydroxy-8-methoxy-6-methyl-1H-indolizino(8,1-cd)carbazole-5-carboxylate
- 1H-Indolizino(8,1-cd)carbazole-5-carboxylic acid, 4-(acetyloxy)-3a-ethyl-9-(5-ethyl-1,4,5,6,7,8,9,10-octahydro-5-hydroxy-9-(methoxycarbonyl)-2H-3,7-methanoazacycloundecino(5,4-b)indol-9-yl)-3a,4,5,5a,6,11,12,13a-octahydro-5-hydroxy-8-methoxy-6-methyl-, methyl ester, (3aR-(3aalpha,4beta,5beta,5abeta,9(3R*,5S*,7R*,9S*),10bR*,13aalpha))-
- 29060-LE
- CCRIS 9002
- EINECS 212-734-0
- HSDB 3263
- NCI-C04842
- NDC 0002-1452-01
- Nincaluicolflastine
- NSC 47842
- NSC 49842
- Rozevin
- UNII-5V9KLZ54CY
- Vinblastin
- Vinblastina
- Vinblastina [DCIT]
- Vinblastine
- Vinblastinum
- Vinblastinum [INN-Latin]
- Vincaleucoblastin
- Vincaleucoblastine
- Vincaleukoblastine
- Vincoblastine
- VLB
- VR-8
Systematic Names
- Vinblastine
- Vincaleukoblastine
Registry Numbers
CAS Registry Number
- 865-21-4
FDA UNII
- 5V9KLZ54CY
System Generated Number
- 0000865214
Structure Descriptors
InChI
1S/C46H58N4O9/c1-8-42(54)23-28-24-45(40(52)57-6,36-30(15-19-49(25-28)26-42)29-13-10-11-14-33(29)47-36)32-21-31-34(22-35(32)56-5)48(4)38-44(31)17-20-50-18-12-16-43(9-2,37(44)50)39(59-27(3)51)46(38,55)41(53)58-7/h10-14,16,21-22,28,37-39,47,54-55H,8-9,15,17-20,23-26H2,1-7H3/t28-,37-,38+,39+,42-,43+,44+,45-,46-/m0/s1InChIKey
JXLYSJRDGCGARV-CFWMRBGOSA-NSmiles
CC[C@@]1(C[C@H]2C[C@@](c3c(c4ccccc4[nH]3)Toxicity
| Organism | Test Type | Route | Reported Dose (Normalized Dose) | Effect | Source |
|---|---|---|---|---|---|
| human | TDLo | ocular | 14ug/kg (0.014mg/kg) | SENSE ORGANS AND SPECIAL SENSES: VISUAL FIELD CHANGES: EYE SENSE ORGANS AND SPECIAL SENSES: CONJUNCTIVE IRRITATION: EYE SENSE ORGANS AND SPECIAL SENSES: OTHER: EYE | British Journal of Ophthalmology. Vol. 62, Pg. 97, 1978. |
| man | LDLo | intravenous | 2319ug/kg/38W (2.319mg/kg) | CARDIAC: CARDIOMYOPATHY INCLUDING INFARCTION | Lancet. Vol. 2, Pg. 692, 1980. |
| man | TDLo | unreported | 80ug/kg (0.08mg/kg) | BLOOD: CHANGES IN BONE MARROW NOT INCLUDED ABOVE | Cancer Chemotherapy Reports. Vol. 50, Pg. 219, 1966. |
| mouse | LD10 | subcutaneous | 20mg/kg (20mg/kg) | European Journal of Cancer. Vol. 10, Pg. 667, 1974. | |
| mouse | LD50 | intraperitoneal | 3120ug/kg (3.12mg/kg) | BLOOD: CHANGES IN BONE MARROW NOT INCLUDED ABOVE IMMUNOLOGICAL INCLUDING ALLERGIC: DECREASED IMMUNE RESPONSE | Cancer Treatment Reports. Vol. 61, Pg. 103, 1977. |
| mouse | LD50 | intravenous | 15mg/kg (15mg/kg) | United States Patent Document. Vol. #4279915, | |
| rat | LD50 | intravenous | 2mg/kg (2mg/kg) | Arzneimittel-Forschung. Drug Research. Vol. 20, Pg. 1467, 1970. |
Physical Properties
| Physical Property | Value | Units | Temp (deg C) | Source |
|---|---|---|---|---|
| log P (octanol-water) | 3.7 | (none) | EXP | |
| Atmospheric OH Rate Constant | 6.44E-10 | cm3/molecule-sec | 25 | EST |
Physical property data is provided to ChemIDplus by SRC, Inc.