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Substance Name: Belinostat [USAN:INN]
RN: 866323-14-0
UNII: F4H96P17NZ
InChIKey: NCNRHFGMJRPRSK-MDZDMXLPSA-N

Notes

  • A hydroxamate-type inhibitor of histone deacetylase.
  • A hydroxamate-type inhibitor of histone deacetylase.

    NCI: A novel hydroxamic acid-type histone deacetylase (HDAC) inhibitor with antineoplastic activity. Belinostat targets HDAC enzymes, thereby inhibiting tumor cell proliferation, inducing apoptosis, promoting cellular differentiation, and inhibiting angiogenesis. This agent may sensitize drug-resistant tumor cells to other antineoplastic agents, possibly through a mechanism involving the down-regulation of thymidylate synthase. (NCI Thesaurus)

Molecular Formula

  • C15-H14-N2-O4-S

Molecular Weight

  • 318.3516
 

Classification Codes

  • Antineoplastic Agents
  • Enzyme Inhibitors
  • Histone Deacetylase Inhibitors
  • Treatment of Cancer

Names and Synonyms

Name of Substance

  • Belinostat [USAN:INN]

Synonyms

  • Beleodaq
  • Belinostat
  • E-Belinostat
  • PX 105684
  • PXD 101
  • UNII-F4H96P17NZ

Systematic Name

  • 2-Propenamide, N-hydroxy-3-(3-((phenylamino)sulfonyl)phenyl)-, (2E)-

Registry Numbers

CAS Registry Number

  • 866323-14-0

FDA UNII

  • F4H96P17NZ

System Generated Number

  • 0866323140

Structure Descriptors

InChI

1S/C15H14N2O4S/c18-15(16-19)10-9-12-5-4-8-14(11-12)22(20,21)17-13-6-2-1-3-7-13/h1-11,17,19H,(H,16,18)/b10-9+

InChIKey

NCNRHFGMJRPRSK-MDZDMXLPSA-N

Smiles

c1ccc(cc1)NS(=O)(=O)c2cccc(c2)/C=C/C(=O)NO