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Substance Name: Dulanermin [USAN:INN]
RN: 867153-61-5
UNII: L65E7T81M5

Note

  • Dulanermin is the recombinant protein; DATR is a recombinant soluble mutant; RefSeq NM_003810.

Classification Code

  • Treatment of Metastatic Non-Small Cell Lung Cancer

Molecular Formula

  • C871-H1329-N243-O260-S4

Molecular Weight

  • 19492.7851
 
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Links to Resources

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Names and Synonyms

Name of Substance

  • Dulanermin [USAN:INN]

Synonyms

  • AMG 951
  • Apo2L/TRAIL
  • Dulanermin
  • Human tumor necrosis factor ligand superfamily member 10 (TNF-related apoptosis-inducing ligand or Apo-2 ligand or CD253 antigen)-(114-281)-peptide (C-terminal part of the extracellular domain), noncovalent homotrimer
  • RG 3639
  • rhApo2L/TRAIL
  • UNII-L65E7T81M5

Systematic Name

  • 114-281-Protein TRAIL (tumor necrosis factor-related apoptosis-inducing ligand) (synthetic human)

Registry Numbers

CAS Registry Number

  • 867153-61-5

FDA UNII

  • L65E7T81M5

System Generated Number

  • 0867153615

Structure Descriptors

Smiles

CC[C@H](C)[C@H](NC(=O)CNC(=O)CNC(=O)[C@H](CCC(=O)N)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](NC(=O)[C@H](CO)NC(=O)[C@H](Cc2ccc(O)cc2)NC(=O)[C@H](CC(C)C)NC(=O)CNC(=O)[C@H](Cc3ccc(O)cc3)NC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](C)NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CO)NC(=O)[C@H](Cc4c[nH]c5ccccc45)NC(=O)[C@H](CS)NC(=O)[C@H](CO)NC(=O)[C@H](CC(=O)N)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](C)NC(=O)[C@H](CO)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCSC)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](NC(=O)[C@@H]6CCCN6C(=O)[C@H](CC(=O)O)NC(=O)[C@@H]7CCCN7C(=O)[C@H](Cc8ccc(O)cc8)NC(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)[C@H](Cc9ccc(O)cc9)NC(=O)[C@H](CCCCN)NC(=O)[C@H](Cc%10ccc(O)cc%10)NC(=O)[C@@H](NC(=O)[C@H](Cc%11ccc(O)cc%11)NC(=O)[C@H](CCC(=O)N)NC(=O)[C@@H](NC(=O)[C@H](CCSC)NC(=O)[C@H](CCC(=O)N)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](CC(=O)N)NC(=O)[C@H](CCCCN)NC(=O)[C@@H](NC(=O)[C@H](CC(=O)N)NC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](CCCCN)NC(=O)[C@@H](NC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](CCC(=O)N)NC(=O)[C@H](Cc%12ccccc%12)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](Cc%13ccccc%13)NC(=O)[C@H](Cc%14ccc(O)cc%14)NC(=O)[C@@H](NC(=O)[C@H](CCC(=O)N)NC(=O)[C@H](CO)NC(=O)[C@H](Cc%15ccc(O)cc%15)NC(=O)[C@@H](NC(=O)[C@H](Cc%16ccc(O)cc%16)NC(=O)[C@H](Cc%17ccc(O)cc%17)NC(=O)[C@H](Cc%18ccccc%18)NC(=O)CNC(=O)[C@H](CCCCN)NC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](Cc%19cnc[nH]%19)NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCC(=O)O)NC(=O)CNC(=O)[C@H](CC(=O)N)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc%20cnc[nH]%20)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(=O)N)NC(=O)[C@H](CO)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc%21ccccc%21)NC(=O)[C@H](CO)NC(=O)[C@H](Cc%22cnc[nH]%22)NC(=O)CNC(=O)[C@H](CO)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](CO)NC(=O)[C@H](CO)NC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](Cc%23c[nH]c%24ccccc%23%24)NC(=O)[C@H](CO)NC(=O)[C@H](CC(=O)N)NC(=O)[C@@H](NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCCNC(=N)N)NC(=O)CNC(=O)[C@H](CC(C)C)NC(=O)[C@H](C)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](CC(=O)N)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CO)NC(=O)[C@H](CC(=O)N)NC(=O)[C@@H]%25CCCN%25C(=O)[C@H](CO)NC(=O)[C@H](CO)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](NC(=O)[C@H](CC(=O)N)NC(=O)[C@H](CO)NC(=O)[C@H](CCCNC(=N)N)NC(=O)CNC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](NC(=O)CNC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@H](Cc%26cnc[nH]%26)NC(=O)[C@H](C)NC(=O)[C@H](C)NC(=O)[C@@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](CCC(=O)N)NC(=O)[C@@H]%27CCCN%27C(=O)CNC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](N)C(C)C)C(C)C)[C@@H](C)CC)[C@@H](C)O)[C@@H](C)O)[C@@H](C)O)[C@@H](C)CC)C(C)C)[C@@H](C)CC)[C@@H](C)CC)[C@@H](C)O)[C@@H](C)CC)[C@@H](C)O)C(C)C)[C@@H](C)CC)[C@@H](C)O)[C@@H](C)CC)[C@@H](C)CC)C(=O)N[C@@H](Cc%28ccccc%28)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](CC(=O)N)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](Cc%29ccccc%29)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CO)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CC(=O)N)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](Cc%30cnc[nH]%30)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](CCSC)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc%31cnc[nH]%31)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](C)C(=O)N[C@@H](CO)C(=O)N[C@@H](Cc%32ccccc%32)C(=O)N[C@@H](Cc%33ccccc%33)C(=O)NCC(=O)N[C@@H](C)C(=O)N[C@@H](Cc%34ccccc%34)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](C(C)C)C(=O)NCC(=O)O