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Substance Name: Linsitinib [USAN:INN]
RN: 867160-71-2
UNII: 15A52GPT8T
InChIKey: PKCDDUHJAFVJJB-VLZXCDOPSA-N

Note

  • An insulin-like growth factor I receptor (IGFIR) tyrosine kinase inhibitor

    NCI: An orally bioavailable small molecule inhibitor of the insulin-like growth factor 1 receptor (IGF-1R) with potential antineoplastic activity. Linsitinib selectively inhibits IGF-1R, which may result in the inhibition of tumor cell proliferation and the induction of tumor cell apoptosis. Overexpressed in a variety of human cancers, IGFR-1 stimulates cell proliferation, enables oncogenic transformation, and suppresses apoptosis.(NCI Thesaurus)

Molecular Formula

  • C26-H23-N5-O

Molecular Weight

  • 421.5017
 

Classification Code

  • Treatment of Solid Tumors
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Names and Synonyms

Name of Substance

  • Linsitinib [USAN:INN]

Synonyms

  • Linsitinib
  • OSI 906
  • OSI-906
  • OSI-906AA
  • OSI906
  • UNII-15A52GPT8T

Registry Numbers

CAS Registry Number

  • 867160-71-2

FDA UNII

  • 15A52GPT8T

System Generated Number

  • 0867160712

Structure Descriptors

InChI

1S/C26H23N5O/c1-26(32)14-19(15-26)25-30-22(23-24(27)28-11-12-31(23)25)18-8-7-17-9-10-20(29-21(17)13-18)16-5-3-2-4-6-16/h2-13,19,32H,14-15H2,1H3,(H2,27,28)/t19-,26+

InChIKey

PKCDDUHJAFVJJB-VLZXCDOPSA-N

Smiles

C[C@@]1(O)C[C@@H](C1)c2nc(c3ccc4ccc(nc4c3)c5ccccc5)c6c(N)nccn26