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Substance Name: Aranidipine [INN]
RN: 86780-90-7
UNII: 4Y7UR6X2PO
InChIKey: NCUCGYYHUFIYNU-UHFFFAOYSA-N

Classification Codes

  • Drug / Therapeutic Agent
  • Reproductive Effect

Molecular Formula

  • C19-H20-N2-O7

Molecular Weight

  • 388.374
 
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Names and Synonyms

Name of Substance

  • Aranidipine
  • Aranidipine [INN]

Synonyms

  • Aranidipine
  • CCRIS 6724
  • MPC 1304
  • UNII-4Y7UR6X2PO

Systematic Names

  • (+-)-Acetonyl methyl 1,4-dihydro-2,6-dimethyl-4-(o-nitrophenyl)-3,5-pyridinedicarboxylate
  • 3,5-Pyridinedicarboxylic acid, 1,4-dihydro-2,6-dimethyl-4-(2-nitrophenyl)-, methyl 2-oxopropyl ester
  • Mpc-1304

Registry Numbers

CAS Registry Number

  • 86780-90-7

FDA UNII

  • 4Y7UR6X2PO

System Generated Number

  • 0086780907

Structure Descriptors

InChI

1S/C19H20N2O7/c1-10(22)9-28-19(24)16-12(3)20-11(2)15(18(23)27-4)17(16)13-7-5-6-8-14(13)21(25)26/h5-8,17,20H,9H2,1-4H3

InChIKey

NCUCGYYHUFIYNU-UHFFFAOYSA-N

Smiles

COC(=O)C1=C(C)NC(=C(C1c2ccccc2[N+](=O)[O-])C(=O)OCC(=O)C)C

Toxicity

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
dog LD50 oral 3333mg/kg (3333mg/kg) BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD

CARDIAC: CHANGE IN RATE

LUNGS, THORAX, OR RESPIRATION: CYANOSIS
Yakuri to Chiryo. Pharmacology and Therapeutics. Vol. 21(Suppl,
mouse LD50 intraperitoneal 7300ug/kg (7.3mg/kg) LUNGS, THORAX, OR RESPIRATION: RESPIRATORY DEPRESSION

BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD

BLOOD: NORMOCYTIC ANEMIA
Yakuri to Chiryo. Pharmacology and Therapeutics. Vol. 21(Suppl,
mouse LD50 oral 143mg/kg (143mg/kg) LUNGS, THORAX, OR RESPIRATION: RESPIRATORY DEPRESSION

BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD

BLOOD: NORMOCYTIC ANEMIA
Yakuri to Chiryo. Pharmacology and Therapeutics. Vol. 21(Suppl,
rat LD50 oral 1459mg/kg (1459mg/kg) BLOOD: NORMOCYTIC ANEMIA

BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD
Yakuri to Chiryo. Pharmacology and Therapeutics. Vol. 21(Suppl,