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Substance Name: Carumonam sodium [USAN:JAN]
RN: 86832-68-0
UNII: B4J4M4939D
InChIKey: BGGXRVPCJUKHTQ-AHCAJXDVSA-L

Classification Codes

  • Antibacterial
  • Drug / Therapeutic Agent
  • Mutation Data
  • Reproductive Effect

Molecular Formula

  • C12-H14-N6-O10-S2.2Na

Molecular Weight

  • 510.371
 
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Names and Synonyms

Name of Substance

  • Carumonam disodium salt
  • Carumonam sodium [USAN:JAN]

Synonyms

  • (Z)-((((2-Amino-4-thiazolyl)(((2S,3S)-2-(hydroxymethyl)-4-oxo-1-sulfo-3-azetidinyl)carbamoyl)methylene)amino)oxy)acetic acid, carbamate (ester), disodium salt
  • Acetic acid, (((2-((2-(((aminocarbonyl)oxy)methyl)-4-oxo-1-sulfo-3-azetidinyl)amino)-1-(2-amino-4-thiazolyl)-2-oxoethylidene)amino)oxy)-, disodium salt, (2S-(2alpha,3alpha(Z)))-
  • AMA 1080
  • AMA 1080(2Na)
  • Carumonam sodium
  • Ro 17-2301/006
  • UNII-B4J4M4939D

Systematic Names

  • Acetic acid, (((2-((2-(((aminocarbonyl)oxy)methyl)-4-oxo-1-sulfo-3-azetidinyl)amino)-1-(2-amino-4-thiazolyl)-2-oxoethylidene)amino)oxy)-, disodium salt, (2S-(2-alpha,3-alpha(Z)))-
  • Acetic acid, (((2-((2-(((aminocarbonyl)oxy)methyl)-4-oxo-1-sulfo-3-azotidinyl)amino)-1-(2-amino-4-thiazolyl)-2-oxoethylidene)amino)oxy)-, disodium salt, (2S-(2-alpha,3-alpha(Z)))-

Registry Numbers

CAS Registry Number

  • 86832-68-0

FDA UNII

  • B4J4M4939D

System Generated Number

  • 0086832680

Molecular Formulas

Molecular Formula

  • C12-H14-N6-O10-S2.2Na

Molecular Formula Fragments

  • C12-H14-N6-O10-S2
  • COMPONENT
  • Na

Structure Descriptors

InChI

1S/C12H14N6O10S2.2Na/c13-11-15-4(3-29-11)7(17-28-2-6(19)20)9(21)16-8-5(1-27-12(14)23)18(10(8)22)30(24,25)26;;/h3,5,8H,1-2H2,(H2,13,15)(H2,14,23)(H,16,21)(H,19,20)(H,24,25,26);;/q;2*+1/p-2/b17-7-;;/t5-,8+;;/m1../s1

InChIKey

BGGXRVPCJUKHTQ-AHCAJXDVSA-L

Smiles

C1([C@H]([C@H](N1S(=O)(=O)[O-])COC(N)=O)NC(\C(c1nc(N)sc1)=N/OCC(=O)[O-])=O)=O.[Na+].[Na+]

Toxicity

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
dog LD50 intravenous > 1gm/kg (1000mg/kg)   Gekkan Yakuji. Pharmaceuticals Monthly. Vol. 30, Pg. 792, 1988.
mouse LD50 intraperitoneal 8870mg/kg (8870mg/kg)   Iyakuhin Kenkyu. Study of Medical Supplies. Vol. 19, Pg. 164, 1988.
mouse LD50 intravenous 7740mg/kg (7740mg/kg) LUNGS, THORAX, OR RESPIRATION: DYSPNEA

SENSE ORGANS AND SPECIAL SENSES: OTHER: EYE
Yakuri to Chiryo. Pharmacology and Therapeutics. Vol. 14, Pg. 3675, 1986.
mouse LD50 oral > 10gm/kg (10000mg/kg) GASTROINTESTINAL: "HYPERMOTILITY, DIARRHEA" Yakuri to Chiryo. Pharmacology and Therapeutics. Vol. 14, Pg. 3675, 1986.
mouse LD50 subcutaneous 8870mg/kg (8870mg/kg) BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)

BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD
Yakuri to Chiryo. Pharmacology and Therapeutics. Vol. 14, Pg. 3675, 1986.
rat LD50 intraperitoneal 10gm/kg (10000mg/kg)   Iyakuhin Kenkyu. Study of Medical Supplies. Vol. 19, Pg. 164, 1988.
rat LD50 intravenous 4650mg/kg (4650mg/kg) LUNGS, THORAX, OR RESPIRATION: DYSPNEA

BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)
Yakuri to Chiryo. Pharmacology and Therapeutics. Vol. 14, Pg. 3675, 1986.
rat LD50 oral > 10gm/kg (10000mg/kg) GASTROINTESTINAL: "HYPERMOTILITY, DIARRHEA" Yakuri to Chiryo. Pharmacology and Therapeutics. Vol. 14, Pg. 3675, 1986.
rat LD50 subcutaneous 10gm/kg (10000mg/kg) BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)

SKIN AND APPENDAGES (SKIN): HAIR: OTHER

LUNGS, THORAX, OR RESPIRATION: DYSPNEA
Yakuri to Chiryo. Pharmacology and Therapeutics. Vol. 14, Pg. 3675, 1986.