Skip Navigation
ChemIDplus A TOXNET DATABASE LiteBrowseAdvanced

Substance Name: Carfilzomib [USAN:INN]
RN: 868540-17-4
UNII: 72X6E3J5AR
InChIKey: BLMPQMFVWMYDKT-NZTKNTHTSA-N

Notes

  • An antineoplastic agent that inhibits the ubiquitin-proteasome pathway.
  • An antineoplastic agent that inhibits the ubiquitin-proteasome pathway.

    NCI: An epoxomicin derivate with potential antineoplastic activity. Carfilzomib irreversibly binds to and inhibits the chymotrypsin-like activity of the 20S proteasome, an enzyme responsible for degrading a large variety of cellular proteins. Inhibition of proteasome-mediated proteolysis results in an accumulation of polyubiquinated proteins, which may lead to cell cycle arrest, induction of apoptosis, and inhibition of tumor growth.(NCI Thesaurus)

Molecular Formula

  • C40-H57-N5-O7

Molecular Weight

  • 719.9183
 

Classification Code

  • Treatment of Cancer

Names and Synonyms

Name of Substance

  • Carfilzomib
  • Carfilzomib [USAN:INN]

Synonyms

  • (2S)-N-((1S)-1-Benzyl-2-(((1S)-3-methyl-1-(((2R)-2-methyloxiran-2-yl)carbonyl)butyl)amino)-2-oxoethyl)-4-methyl-2-(((2S)-2-((morpholin-4-ylacetyl)amino)-4-phenylbutanoyl)amino)pentanamide
  • Carfilzomib
  • Kyprolis
  • PR-171
  • UNII-72X6E3J5AR

Systematic Name

  • L-Phenylalaninamide, (alphaS)-alpha-((4-morpholinylacetyl)amino)benzenebutanoyl-L-leucyl-N-((1S)-3-methyl-1-(((2R)-2-methyloxiranyl)carbonyl)butyl)-

Registry Numbers

CAS Registry Number

  • 868540-17-4

FDA UNII

  • 72X6E3J5AR

System Generated Number

  • 0868540174

Structure Descriptors

InChI

1S/C40H57N5O7/c1-27(2)22-32(36(47)40(5)26-52-40)42-39(50)34(24-30-14-10-7-11-15-30)44-38(49)33(23-28(3)4)43-37(48)31(17-16-29-12-8-6-9-13-29)41-35(46)25-45-18-20-51-21-19-45/h6-15,27-28,31-34H,16-26H2,1-5H3,(H,41,46)(H,42,50)(H,43,48)(H,44,49)/t31-,32-,33-,34-,40+/m0/s1

InChIKey

BLMPQMFVWMYDKT-NZTKNTHTSA-N

Smiles

CC(C)C[C@H](NC(=O)[C@H](CCc1ccccc1)NC(=O)CN2CCOCC2)C(=O)N[C@@H](Cc3ccccc3)C(=O)N[C@@H](CC(C)C)C(=O)[C@@]4(C)CO4