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Substance Name: Isosorbide dinitrate [USAN:USP:INN:BAN:JAN]
RN: 87-33-2
UNII: IA7306519N
InChIKey: MOYKHGMNXAOIAT-JGWLITMVSA-N

Note

  • A vasodilator used in the treatment of ANGINA PECTORIS. Its actions are similar to NITROGLYCERIN but with a slower onset of action.

Molecular Formula

  • C6-H8-N2-O8

Molecular Weight

  • 236.135
 

Classification Codes

  • Cardiovascular Agents
  • Drug / Therapeutic Agent
  • Human Data
  • Mutation Data
  • Nitric Oxide Donors
  • Reproductive Effect
  • Skin / Eye Irritant
  • Vasodilator (Coronary)
  • Vasodilator Agents
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Names and Synonyms

Name of Substance

  • Isosorbide dinitrate
  • Isosorbide dinitrate [USAN:USP:INN:BAN:JAN]

MeSH Heading

  • Isosorbide dinitrate

Synonyms

  • 1,4:3,6-Dianhydro-D-glucitol dinitrate
  • 1,4:3,6-Dianhydrosorbitol 2,5-dinitrate
  • Angidil
  • Astridine
  • Cardio 10
  • Cardis
  • Cardonit 40
  • Carvanil
  • Carvasin
  • CCRIS 1910
  • Cedocard
  • Claodical
  • Cornilat
  • Coronex
  • Corosorbide
  • Corovliss
  • D-Isosorbide dinitrate
  • Dianhydrosorbitol 2,5-dinitrate
  • Difutrat
  • Dignionitrat
  • Dilatrate
  • Dilatrate SR
  • Dilatrate-SR
  • Diniket
  • Dinitrate d'isosorbide
  • Dinitrate d'isosorbide [INN-French]
  • Dinitrato de isosorbida
  • Dinitrato de isosorbida [INN-Spanish]
  • Dinitroisosorbide
  • Dinitrosorbide
  • Disorlon
  • EC 201-740-9
  • EINECS 201-740-9
  • Emoper
  • EureCor
  • Flindix
  • Frandol
  • Glucitol, 1,4:3,6-dianhydro-, dinitrate, D-
  • Harrical
  • HSDB 3417
  • IBD 20
  • ISDN
  • Iso-bid
  • Iso-Mack
  • Iso-Puren
  • Isochron
  • Isoket
  • Isoket Retard 120
  • Isoket retard 40
  • Isomak R
  • Isorbid
  • Isordil
  • Isordil Tembids
  • Isosorbide 2,5-dinitrate
  • Isosorbide dinitrate
  • Isosorbide dinitrato
  • Isosorbide dinitrato [DCIT]
  • Isosorbidi dinitras
  • Isosorbidi dinitras [INN-Latin]
  • Isosorbidi nitras
  • Isotrate
  • Korodil
  • Langoran
  • Laserdil
  • Lomilan
  • Maycor
  • Myorexon
  • Nitrosorbid
  • Nitrosorbide
  • Nitrosorbon
  • Nosim
  • NSC 80038
  • Resoidan
  • Rifloc Retard
  • Rigedal
  • Sorate-10
  • Sorate-5
  • Sorbangil
  • Sorbide
  • Sorbide nitrate
  • Sorbide, dinitrate
  • Sorbidi nitras
  • Sorbidilat
  • Sorbidinitrate
  • Sorbidnitrate
  • Sorbislo
  • Sorbitrate
  • Sorbonit
  • Sorquad
  • Sorquat
  • SST-101
  • Tinidil
  • TYB 3215
  • UNII-IA7306519N
  • Vascardin
  • Vasodilat
  • Vasorbate
  • Xanyl

Systematic Names

  • D-Glucitol, 1,4:3,6-dianhydro-, 2,5-dinitrate
  • D-Glucitol, 1,4:3,6-dianhydro-, dinitrate
  • Glucitol, 1,4:3,6-dianhydro-, dinitrate, D-
  • Isodinit
  • Isosorbide dinitrate

Superlist Names

  • Isosorbide dinitrate mixture with not <60% lactose, mannose, starch or calcium hydrogen phosphate
  • Isosorbide dinitrate mixture with not <60% lactose, mannose, starch or calcium hydrogen phosphate [UN2907] [Flammable solid]
  • UN2907

Mixture Names

  • Bidil
  • Dilatrate-SR
  • SDM No. 40
  • SDM No. 50

Registry Numbers

CAS Registry Number

  • 87-33-2

FDA UNII

  • IA7306519N

Other Registry Numbers

  • 54650-95-2
  • 6659-58-1

System Generated Number

  • 0000087332

Structure Descriptors

InChI

InChI=1S/C6H8N2O8/c9-7(10)15-3-1-13-6-4(16-8(11)12)2-14-5(3)6/h3-6H,1-2H2/t3-,4+,5-,6-/m1/s1

InChIKey

MOYKHGMNXAOIAT-JGWLITMVSA-N

Smiles

[O-][N+](=O)O[C@H]1CO[C@@H]2[C@@H](CO[C@H]12)O[N+](=O)[O-]

Toxicity

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
mammal (species unspecified) LD50 unreported 1109mg/kg (1109mg/kg)   French Demande Patent Document. Vol. #2454807,
man TDLo oral 1714ug/kg/3D- (1.714mg/kg) BLOOD: METHEMOGLOBINEMIA-CARBOXYHEMOGLOBIN

LUNGS, THORAX, OR RESPIRATION: CYANOSIS		 Australian and New Zealand Journal of Medicine. Vol. 27, Pg. 596, 1997.
mouse LD50 intramuscular 1080mg/kg (1080mg/kg)   Drugs in Japan Vol. 6, Pg. 72, 1982.
mouse LD50 intraperitoneal 720mg/kg (720mg/kg)   Yakkyoku. Pharmacy. Vol. 24, Pg. 431, 1973.
mouse LD50 intravenous > 40mg/kg (40mg/kg) SKIN AND APPENDAGES (SKIN): HAIR: OTHER

BEHAVIORAL: ATAXIA		 Kiso to Rinsho. Clinical Report. Vol. 19, Pg. 4947, 1985.
mouse LD50 oral 1050mg/kg (1050mg/kg)   Drugs in Japan Vol. 6, Pg. 72, 1982.
mouse LD50 subcutaneous 1050mg/kg (1050mg/kg)   Drugs in Japan Vol. 6, Pg. 72, 1982.
rabbit LD50 intravenous > 40mg/kg (40mg/kg) BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)

BEHAVIORAL: ATAXIA		 Kiso to Rinsho. Clinical Report. Vol. 19, Pg. 4947, 1985.
rat LD50 intramuscular > 2gm/kg (2000mg/kg)   Drugs in Japan Vol. 6, Pg. 72, 1982.
rat LD50 intraperitoneal 670mg/kg (670mg/kg) BEHAVIORAL: CHANGES IN MOTOR ACTIVITY (SPECIFIC ASSAY)

SENSE ORGANS AND SPECIAL SENSES: PTOSIS: EYE

LUNGS, THORAX, OR RESPIRATION: RESPIRATORY DEPRESSION		 Oyo Yakuri. Pharmacometrics. Vol. 35, Pg. 287, 1988.
rat LD50 intravenous > 40mg/kg (40mg/kg) BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)

BEHAVIORAL: ATAXIA		 Kiso to Rinsho. Clinical Report. Vol. 19, Pg. 4947, 1985.
rat LD50 oral 747mg/kg (747mg/kg)   Gekkan Yakuji. Pharmaceuticals Monthly. Vol. 26, Pg. 309, 1984.
rat LD50 skin > 3gm/kg (3000mg/kg)   Oyo Yakuri. Pharmacometrics. Vol. 35, Pg. 287, 1988.
rat LD50 subcutaneous 1237mg/kg (1237mg/kg) BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD

BEHAVIORAL: EXCITEMENT		 Yakuri to Chiryo. Pharmacology and Therapeutics. Vol. 10, Pg. 2109, 1982.
women TDLo oral 100ug/kg (0.1mg/kg) CARDIAC: PULSE RATE

BEHAVIORAL: COMA

CARDIAC: OTHER CHANGES		 Southern Medical Journal. Vol. 84, Pg. 369, 1991.

Physical Properties

Physical Property Value Units Temp (deg C) Source
Melting Point 70 deg C   EXP
log P (octanol-water) 1.31 (none)   EXP
Water Solubility 550 mg/L 25 EXP
Vapor Pressure 4.55E-04 mm Hg 25 EST
Henry's Law Constant 4.19E-12 atm-m3/mole 25 EST
Atmospheric OH Rate Constant 4.99E-12 cm3/molecule-sec 25 EST

Physical property data is provided to ChemIDplus by SRC, Inc.