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Substance Name: Isosorbide dinitrate [USAN:USP:INN:BAN:JAN]
RN: 87-33-2
UNII: IA7306519N
InChIKey: MOYKHGMNXAOIAT-JGWLITMVSA-N
Note
- A vasodilator used in the treatment of ANGINA PECTORIS. Its actions are similar to NITROGLYCERIN but with a slower onset of action.
Molecular Formula
- C6-H8-N2-O8
Molecular Weight
- 236.135
- All
- Classifications
- Links to Resources
- Names & Synonyms
- Registry Numbers
- Structure Descriptors
- Toxicity
- Physical Properties
Classification Codes
- Cardiovascular Agents
- Drug / Therapeutic Agent
- Human Data
- Mutation Data
- Nitric Oxide Donors
- Reproductive Effect
- Skin / Eye Irritant
- Vasodilator (Coronary)
- Vasodilator Agents
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Names and Synonyms
Name of Substance
- Isosorbide dinitrate
- Isosorbide dinitrate [USAN:USP:INN:BAN:JAN]
MeSH Heading
- Isosorbide dinitrate
Synonyms
- 1,4:3,6-Dianhydro-D-glucitol dinitrate
- 1,4:3,6-Dianhydrosorbitol 2,5-dinitrate
- Angidil
- Astridine
- Cardio 10
- Cardis
- Cardonit 40
- Carvanil
- Carvasin
- CCRIS 1910
- Cedocard
- Claodical
- Cornilat
- Coronex
- Corosorbide
- Corovliss
- D-Isosorbide dinitrate
- Dianhydrosorbitol 2,5-dinitrate
- Difutrat
- Dignionitrat
- Dilatrate
- Dilatrate SR
- Dilatrate-SR
- Diniket
- Dinitrate d'isosorbide
- Dinitrate d'isosorbide [INN-French]
- Dinitrato de isosorbida
- Dinitrato de isosorbida [INN-Spanish]
- Dinitroisosorbide
- Dinitrosorbide
- Disorlon
- EC 201-740-9
- EINECS 201-740-9
- Emoper
- EureCor
- Flindix
- Frandol
- Glucitol, 1,4:3,6-dianhydro-, dinitrate, D-
- Harrical
- HSDB 3417
- IBD 20
- ISDN
- Iso-bid
- Iso-Mack
- Iso-Puren
- Isochron
- Isoket
- Isoket Retard 120
- Isoket retard 40
- Isomak R
- Isorbid
- Isordil
- Isordil Tembids
- Isosorbide 2,5-dinitrate
- Isosorbide dinitrate
- Isosorbide dinitrato
- Isosorbide dinitrato [DCIT]
- Isosorbidi dinitras
- Isosorbidi dinitras [INN-Latin]
- Isosorbidi nitras
- Isotrate
- Korodil
- Langoran
- Laserdil
- Lomilan
- Maycor
- Myorexon
- Nitrosorbid
- Nitrosorbide
- Nitrosorbon
- Nosim
- NSC 80038
- Resoidan
- Rifloc Retard
- Rigedal
- Sorate-10
- Sorate-5
- Sorbangil
- Sorbide
- Sorbide nitrate
- Sorbide, dinitrate
- Sorbidi nitras
- Sorbidilat
- Sorbidinitrate
- Sorbidnitrate
- Sorbislo
- Sorbitrate
- Sorbonit
- Sorquad
- Sorquat
- SST-101
- Tinidil
- TYB 3215
- UNII-IA7306519N
- Vascardin
- Vasodilat
- Vasorbate
- Xanyl
Systematic Names
- D-Glucitol, 1,4:3,6-dianhydro-, 2,5-dinitrate
- D-Glucitol, 1,4:3,6-dianhydro-, dinitrate
- Glucitol, 1,4:3,6-dianhydro-, dinitrate, D-
- Isodinit
- Isosorbide dinitrate
Superlist Names
- Isosorbide dinitrate mixture with not <60% lactose, mannose, starch or calcium hydrogen phosphate
- Isosorbide dinitrate mixture with not <60% lactose, mannose, starch or calcium hydrogen phosphate [UN2907] [Flammable solid]
- UN2907
Mixture Names
- Bidil
- Dilatrate-SR
- SDM No. 40
- SDM No. 50
Registry Numbers
CAS Registry Number
- 87-33-2
FDA UNII
- IA7306519N
Other Registry Numbers
- 54650-95-2
- 6659-58-1
System Generated Number
- 0000087332
Structure Descriptors
InChI
InChI=1S/C6H8N2O8/c9-7(10)15-3-1-13-6-4(16-8(11)12)2-14-5(3)6/h3-6H,1-2H2/t3-,4+,5-,6-/m1/s1InChIKey
MOYKHGMNXAOIAT-JGWLITMVSA-NSmiles
[O-][N+](=O)Toxicity
Organism | Test Type | Route | Reported Dose (Normalized Dose) | Effect | Source |
---|---|---|---|---|---|
mammal (species unspecified) | LD50 | unreported | 1109mg/kg (1109mg/kg) | French Demande Patent Document. Vol. #2454807, | |
man | TDLo | oral | 1714ug/kg/3D- (1.714mg/kg) | BLOOD: METHEMOGLOBINEMIA-CARBOXYHEMOGLOBIN LUNGS, THORAX, OR RESPIRATION: CYANOSIS | Australian and New Zealand Journal of Medicine. Vol. 27, Pg. 596, 1997. |
mouse | LD50 | intramuscular | 1080mg/kg (1080mg/kg) | Drugs in Japan Vol. 6, Pg. 72, 1982. | |
mouse | LD50 | intraperitoneal | 720mg/kg (720mg/kg) | Yakkyoku. Pharmacy. Vol. 24, Pg. 431, 1973. | |
mouse | LD50 | intravenous | > 40mg/kg (40mg/kg) | SKIN AND APPENDAGES (SKIN): HAIR: OTHER BEHAVIORAL: ATAXIA | Kiso to Rinsho. Clinical Report. Vol. 19, Pg. 4947, 1985. |
mouse | LD50 | oral | 1050mg/kg (1050mg/kg) | Drugs in Japan Vol. 6, Pg. 72, 1982. | |
mouse | LD50 | subcutaneous | 1050mg/kg (1050mg/kg) | Drugs in Japan Vol. 6, Pg. 72, 1982. | |
rabbit | LD50 | intravenous | > 40mg/kg (40mg/kg) | BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY) BEHAVIORAL: ATAXIA | Kiso to Rinsho. Clinical Report. Vol. 19, Pg. 4947, 1985. |
rat | LD50 | intramuscular | > 2gm/kg (2000mg/kg) | Drugs in Japan Vol. 6, Pg. 72, 1982. | |
rat | LD50 | intraperitoneal | 670mg/kg (670mg/kg) | BEHAVIORAL: CHANGES IN MOTOR ACTIVITY (SPECIFIC ASSAY) SENSE ORGANS AND SPECIAL SENSES: PTOSIS: EYE LUNGS, THORAX, OR RESPIRATION: RESPIRATORY DEPRESSION | Oyo Yakuri. Pharmacometrics. Vol. 35, Pg. 287, 1988. |
rat | LD50 | intravenous | > 40mg/kg (40mg/kg) | BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY) BEHAVIORAL: ATAXIA | Kiso to Rinsho. Clinical Report. Vol. 19, Pg. 4947, 1985. |
rat | LD50 | oral | 747mg/kg (747mg/kg) | Gekkan Yakuji. Pharmaceuticals Monthly. Vol. 26, Pg. 309, 1984. | |
rat | LD50 | skin | > 3gm/kg (3000mg/kg) | Oyo Yakuri. Pharmacometrics. Vol. 35, Pg. 287, 1988. | |
rat | LD50 | subcutaneous | 1237mg/kg (1237mg/kg) | BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD BEHAVIORAL: EXCITEMENT | Yakuri to Chiryo. Pharmacology and Therapeutics. Vol. 10, Pg. 2109, 1982. |
women | TDLo | oral | 100ug/kg (0.1mg/kg) | CARDIAC: PULSE RATE BEHAVIORAL: COMA CARDIAC: OTHER CHANGES | Southern Medical Journal. Vol. 84, Pg. 369, 1991. |
Physical Properties
Physical Property | Value | Units | Temp (deg C) | Source |
---|---|---|---|---|
Melting Point | 70 | deg C | EXP | |
log P (octanol-water) | 1.31 | (none) | EXP | |
Water Solubility | 550 | mg/L | 25 | EXP |
Vapor Pressure | 4.55E-04 | mm Hg | 25 | EST |
Henry's Law Constant | 4.19E-12 | atm-m3/mole | 25 | EST |
Atmospheric OH Rate Constant | 4.99E-12 | cm3/molecule-sec | 25 | EST |
Physical property data is provided to ChemIDplus by SRC, Inc.