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Substance Name: Idelalisib [USAN:INN]
RN: 870281-82-6
UNII: YG57I8T5M0
InChIKey: IFSDAJWBUCMOAH-HNNXBMFYSA-N

Notes

  • An antineoplastic agent and p110delta inhibitor.
  • An antineoplastic agent and p110delta inhibitor.

    NCI: An orally bioavailable, small molecule inhibitor of the delta isoform of the 110 kDa catalytic subunit of class I phosphoinositide-3 kinase (PI3K) with potential immunomodulating and antineoplastic activities. Idelalisib inhibits the production of the second messenger phosphatidylinositol-3,4,5-trisphosphate (PIP3), preventing the activation of the PI3K signaling pathway and inhibiting tumor cell proliferation, motility, and survival. Unlike other isoforms of PI3K, PI3K-delta is expressed primarily in hematopoietic lineages. The targeted inhibition of PI3K-delta is designed to preserve PI3K signaling in normal, non-neoplastic cells. (NCI Thesaurus)

Molecular Weight

  • 415.4302
 

Classification Codes

  • Antineoplastic Agents
  • Enzyme Inhibitors

Names and Synonyms

Name of Substance

  • Idelalisib [USAN:INN]

Synonyms

  • 5-Fluoro-3-phenyl-2-((S)-1-(9H-purin-6-ylamino)-propyl)-3H-quinazolin-4-one
  • CAL-101
  • GS 1101
  • GS-1101
  • Idelalisib
  • UNII-YG57I8T5M0
  • Zydelig

Registry Numbers

CAS Registry Number

  • 870281-82-6

FDA UNII

  • YG57I8T5M0

System Generated Number

  • 0870281826

Structure Descriptors

InChI

1S/C22H18FN7O/c1-2-15(28-20-18-19(25-11-24-18)26-12-27-20)21-29-16-10-6-9-14(23)17(16)22(31)30(21)13-7-4-3-5-8-13/h3-12,15H,2H2,1H3,(H2,24,25,26,27,28)/t15-/m0/s1

InChIKey

IFSDAJWBUCMOAH-HNNXBMFYSA-N

Smiles

CC[C@H](Nc1ncnc2[nH]cnc12)C3=Nc4cccc(F)c4C(=O)N3c5ccccc5