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Substance Name: Ritanserin [USAN:INN:BAN]
RN: 87051-43-2
UNII: 145TFV465S
InChIKey: JUQLTPCYUFPYKE-UHFFFAOYSA-N

Note

  • A selective and potent serotonin-2 antagonist that is effective in the treatment of a variety of syndromes related to anxiety and depression. The drug also improves the subjective quality of sleep and decreases portal pressure.

Molecular Formula

  • C27-H25-F2-N3-O-S

Molecular Weight

  • 477.577
 

Classification Codes

  • Anti-Anxiety Agents
  • Antidepressive Agents
  • Antidepressive Agents, Second-Generation
  • Antipsychotic Agents
  • Central Nervous System Agents
  • Central Nervous System Depressants
  • Neurotransmitter Agents
  • Psychotropic Drugs
  • Serotonin Agents
  • Serotonin Antagonist
  • Serotonin Antagonists
  • Tranquilizing Agents
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Names and Synonyms

Name of Substance

  • Ritanserin
  • Ritanserin [USAN:INN:BAN]

MeSH Heading

  • Ritanserin

Synonyms

  • 6-(2-(4-(Bis(p-fluorophenyl)methylene)-piperidino)ethyl)-7-methyl-5H-thiazolo-(3,2-a)pyrimidin-5-one
  • R 55,667
  • Ritanserin
  • Ritanserina
  • Ritanserina [Spanish]
  • Ritanserine
  • Ritanserine [French]
  • Ritanserinum
  • Ritanserinum [Latin]
  • Tiserton
  • UNII-145TFV465S

Systematic Name

  • 5H-Thiazolo(3,2-a)pyrimidin-5-one, 6-(2-(4-bis(4-fluorophenyl)methylene)-1-piperidinyl)ethyl)-7-methyl-

Registry Numbers

CAS Registry Number

  • 87051-43-2

FDA UNII

  • 145TFV465S

System Generated Number

  • 0087051432

Structure Descriptors

InChI

1S/C27H25F2N3OS/c1-18-24(26(33)32-16-17-34-27(32)30-18)12-15-31-13-10-21(11-14-31)25(19-2-6-22(28)7-3-19)20-4-8-23(29)9-5-20/h2-9,16-17H,10-15H2,1H3

InChIKey

JUQLTPCYUFPYKE-UHFFFAOYSA-N

Smiles

C(=C1\CCN(CCc2c(n3c(scc3)nc2C)=O)CC1)(\c1ccc(F)cc1)c1ccc(F)cc1

Physical Properties

Physical Property Value Units Temp (deg C) Source
log P (octanol-water) 5.2 (none)   EXP
Atmospheric OH Rate Constant 2.81E-10 cm3/molecule-sec 25 EST

Physical property data is provided to ChemIDplus by SRC, Inc.