Skip Navigation
ChemIDplus A TOXNET DATABASE LiteBrowseAdvanced

Substance Name: Leptomycin B
RN: 87081-35-4
UNII: Y031I2N1EO
InChIKey: YACHGFWEQXFSBS-XYERBDPFSA-N

Note

  • From Streptomyces sp. ATS1287.

Molecular Formula

  • C33-H48-O6

Molecular Weight

  • 540.7362
 

Classification Codes

  • Anti-Infective Agents
  • Antibiotics, Antineoplastic
  • Antifungal Agents
  • Antineoplastic Agents
  • Drug / Therapeutic Agent
  • Mutation Data
* denotes mobile formatted website

Links to Resources


Search for this InChIKey on the Web

Names and Synonyms

Name of Substance

  • Leptomycin B

Synonyms

  • Antibiotic CI 940
  • Antibiotic CL 1957A
  • CI-940
  • CL 1957A
  • Elactocin
  • Mantuamycin
  • NSC 364372
  • PD 114720
  • UNII-Y031I2N1EO

Systematic Names

  • 2,10,12,16,18-Nonadecapentaenoic acid, 19-(3,6-dihydro-3-methyl-6-oxo-2H-pyran-2-yl)-17-ethyl-6-hydroxy-3,5,7,9,11,15-hexamethyl-8-oxo-
  • 2,10,12,16,18-Nonadecapentanoic acid, 19-(3,6-dihydro-3-methyl-6-oxo-2H-pyran-2-yl)-17-ethyl-6-hydroxy-3,5,7,9,11,15-hexamethyl-8-oxo-

Registry Numbers

CAS Registry Number

  • 87081-35-4

FDA UNII

  • Y031I2N1EO

System Generated Number

  • 0087081354

Structure Descriptors

InChI

1S/C33H48O6/c1-9-28(14-15-29-24(5)13-16-31(36)39-29)19-22(3)12-10-11-21(2)17-25(6)32(37)27(8)33(38)26(7)18-23(4)20-30(34)35/h10-11,13-17,19-20,22,24-27,29,33,38H,9,12,18H2,1-8H3,(H,34,35)/b11-10+,15-14+,21-17+,23-20+,28-19-/t22-,24+,25-,26+,27-,29+,33-/m1/s1

InChIKey

YACHGFWEQXFSBS-XYERBDPFSA-N

Smiles

CC\C(=C\[C@H](C)C\C=C\C(=C\[C@@H](C)C(=O)[C@@H](C)[C@H](O)[C@@H](C)C\C(=C\C(=O)O)\C)\C)\C=C\[C@@H]1OC(=O)C=C[C@@H]1C

Toxicity

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
mouse LD50 intravenous 3100ug/kg (3.1mg/kg)   "CRC Handbook of Antibiotic Compounds," Vols.1- , Berdy, J., Boca Raton, FL, CRC Press, 1980Vol. 13(3), Pg. 204, 1987.