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Substance Name: Leptomycin A
RN: 87081-36-5
InChIKey: QECBVZBMGUAZDL-DLWOFZAMSA-N

Note

  • From Streptomyces sp. ATS1287.

Classification Codes

  • Drug / Therapeutic Agent
  • Mutation Data

Molecular Formula

  • C32-H46-O6

Molecular Weight

  • 526.709
 
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Names and Synonyms

Name of Substance

  • Leptomycin A

Synonyms

  • Jildamycin
  • Leptomycin A
  • NSC 369326

Systematic Names

  • 2,10,12,16,18-Nonadecapentaenoic acid, 19-(3,6-dihydro-3-methyl-6-oxo-2H-pyran-2-yl)-3,5,7,9,11,15,17-heptamethyl-6-hydroxy-8-oxo-
  • 2,10,12,16,18-Nonadecapentaenoic acid, 19-(3,6-dihydro-3-methyl-6-oxo-2H-pyran-2-yl)-6-hydroxy-3,5,7,9,11,15,17-heptamethyl-8-oxo-

Registry Numbers

CAS Registry Number

  • 87081-36-5

System Generated Number

  • 0087081365

Structure Descriptors

InChI

1S/C32H46O6/c1-20(16-22(3)12-14-28-24(5)13-15-30(35)38-28)10-9-11-21(2)17-25(6)31(36)27(8)32(37)26(7)18-23(4)19-29(33)34/h9,11-17,19-20,24-28,32,37H,10,18H2,1-8H3,(H,33,34)/b11-9+,14-12+,21-17+,22-16+,23-19+

InChIKey

QECBVZBMGUAZDL-DLWOFZAMSA-N

Smiles

C(\[C@@H]1[C@@H](C=CC(O1)=O)C)=C\C(=C\[C@@H](C\C=C\C(=C\[C@@H](C([C@@H]([C@@H]([C@@H](C\C(=C\C(O)=O)C)C)O)C)=O)C)C)C)C

Toxicity

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
mouse LD50 intravenous 10mg/kg (10mg/kg)   "CRC Handbook of Antibiotic Compounds," Vols.1- , Berdy, J., Boca Raton, FL, CRC Press, 1980Vol. 13(3), Pg. 203, 1987.