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Substance Name: Raltegravir potassium [USAN:JAN]
RN: 871038-72-1
UNII: 43Y000U234
InChIKey: IFUKBHBISRAZTF-UHFFFAOYSA-M

Notes

  • A pyrrolidinone derivative and HIV INTEGRASE INHIBITOR that is used in combination with other ANTI-HIV AGENTS for the treatment of HIV INFECTION.
  • An HIV integrase inhibitor; raltegravir is also known as MK-0518.

    NCI: The orally bioavailable potassium salt of a human immunodeficiency virus (HIV) integrase strand transfer inhibitor (HIV-1 INSTI) with HIV-1 antiviral activity. Raltegravir binds to and inhibits integrase, an HIV enzyme that inserts viral genetic material into the genetic material of the infected human cell. Inhibition of integrase prevents insertion of HIV DNA into the human DNA genome, thus blocking HIV replication. (NCI Thesaurus)

Molecular Formula

  • C20-H20-F-K-N6-O5

Molecular Weight

  • 482.511
 

Classification Codes

  • Anti-HIV Agents
  • Anti-Infective Agents
  • Anti-Retroviral Agents
  • Antiviral
  • Antiviral Agents
  • Enzyme Inhibitors
  • HIV Integrase Inhibitors
  • Integrase Inhibitors
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Names and Synonyms

Name of Substance

  • Raltegravir potassium [USAN:JAN]

MeSH Heading

  • Raltegravir Potassium

Synonyms

  • Isentress
  • MK 0518
  • MK-0518
  • MK0518
  • N-((4-Fluorophenyl)methyl)-1,6-dihydro-5-hydroxy-1-methyl-2-(1-methyl-1-(((5-methyl-1,3,4-oxadiazol-2-yl)carbonyl)amino)ethyl)-6-oxo-4-pyrimidinecarboxamide monopotassium salt
  • Potassium 4-((4-fluorobenzyl)carbamoyl)-1-methyl-2-(1-methyl-1-(((5-methyl-1,3,4-oxadiazol-2-yl)carbonyl)amino)ethyl)-6-oxo-1,6-dihydropyrimidin-5-olate
  • Raltegravir potassium
  • UNII-43Y000U234

Systematic Name

  • 4-Pyrimidinecarboxamide, N-((4-fluorophenyl)methyl)-1,6-dihydro-5-hydroxy-1-methyl-2-(1-methyl-1-(((5-methyl-1,3,4-oxadiazol-2-yl)carbonyl)amino)ethyl)-6-oxo-, monopotassium salt

Registry Numbers

CAS Registry Number

  • 871038-72-1

FDA UNII

  • 43Y000U234

Other Registry Number

  • 925701-81-1

System Generated Number

  • 0871038721

Structure Descriptors

InChI

InChI=1S/C20H21FN6O5.K/c1-10-25-26-17(32-10)16(30)24-20(2,3)19-23-13(14(28)18(31)27(19)4)15(29)22-9-11-5-7-12(21)8-6-11;/h5-8,28H,9H2,1-4H3,(H,22,29)(H,24,30);/q;+1/p-1

InChIKey

IFUKBHBISRAZTF-UHFFFAOYSA-M

Smiles

[K+].CN1C(=O)C(=C(N=C1C(C)(C)NC(=O)c2oc(C)nn2)C(=O)NCc3ccc(F)cc3)[O-]